A5090054798- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Cancer Treatment and Pharmacology
- ATP Synthase and ATPases Research
- Sphingolipid Metabolism and Signaling
- Marine Toxins and Detection Methods
- Polymer composites and self-healing
- Analytical chemistry methods development
- Fatty Acid Research and Health
- Microtubule and mitosis dynamics
- Metabolomics and Mass Spectrometry Studies
- Advanced Chemical Sensor Technologies
- Marine Sponges and Natural Products
- Folate and B Vitamins Research
- Meat and Animal Product Quality
- Food Chemistry and Fat Analysis
- Ion-surface interactions and analysis
- Probiotics and Fermented Foods
- Diet, Metabolism, and Disease
- Enzyme Catalysis and Immobilization
- Advanced Chemical Physics Studies
- COVID-19 Clinical Research Studies
- Proteins in Food Systems
- Synthetic Organic Chemistry Methods
- Biochemical Analysis and Sensing Techniques
University of Alberta
2015-2025
Johns Hopkins University
2022-2023
Bloomberg (United States)
2022-2023
Max Planck Institute of Immunobiology and Epigenetics
2022-2023
University of Oxford
2021-2022
Intensive Care National Audit & Research Centre
2021
National Health and Medical Research Council
2021
University of Dundee
2021
Medical Research Council
2021
Public Health Scotland
2021
Two polar lipid-soluble macrocycles 1 and 2, containing a spiro-linked tricyclic ether ring system an unusual seven-membered cyclic iminium moiety, have been isolated from the digestive glands of mussels (Mytilus edulis) scallops (Placopecten magellanicus).
Lactobacilli convert linoleic acid to hydroxy fatty acids; however, this conversion has not been demonstrated in food fermentations and it remains unknown whether acids produced by lactobacilli have antifungal activity. This study aimed determine metabolites with activity assess can be employed delay fungal growth on bread. Aqueous organic extracts from seven strains of grown modified De Man Rogosa Sharpe medium or sourdough were assayed for Lactobacillus hammesii exhibited increased upon...
Abstract Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, frequent and precedes death from metastases. To improve cancer treatment it vital understand mechanisms that result in tamoxifen resistance. This study shows concentrations of its metabolites, which accumulate tumors patients, killed both ERα-positive ERα-negative cells. depended...
Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this essential for vasculogenesis during embryonic development. ATX also involved in wound healing inflammation, tumor growth, metastasis, chemo-resistance. It is, therefore, important to understand how regulated. was proposed that activity inhibited by its product LPA, or related lipid called sphingosine 1-phosphate...
Autotaxin is a secreted enzyme that produces most extracellular lysophosphatidate, which stimulates 6 G-protein-coupled receptors. Lysophosphatidate promotes cancer cell survival, growth, migration, invasion, metastasis, and resistance to chemotherapy radiotherapy. The present work investigated whether inhibiting autotaxin could decrease breast tumor growth metastasis. We used new inhibitor (ONO-8430506; IC90=100 nM), decreased plasma activity by >60% concentrations of unsaturated...
Dietary fiber is an integral part of a healthy diet, but questions remain about the mechanisms that underlie effects and causal contributions gut microbiota. Here, we performed 6-week exploratory trial in adults with excess weight (BMI: 25-35 kg/m2) to compare high-dose (females: 25 g/day; males: 35 g/day) supplement fermentable corn bran arabinoxylan (AX; n = 15) microbiota-non-accessible microcrystalline cellulose (MCC; 16). Obesity-related surrogate endpoints biomarkers host-microbiome...
Three additional marine toxins, spirolides A (1), C (3), and 13-desmethyl-C (7), were isolated from contaminated scallops phytoplankton collections obtained a Nova Scotian aquaculture site, as well batch cultures of the dinoflagellate Alexandrium ostenfeldii single-cell isolate these assemblages. The structures new spirolide derivatives, characterized by mass spectrometry NMR, indicate close relationship with B (2) D (4) previously shellfish in same area. All compounds display "fast-acting"...
Despite recommendations for higher choline intakes during pregnancy and lactation, there is limited research regarding maternal intake these important periods. In the present study, we estimated dietary lactation in a population of Albertan women contribution egg milk consumption to intake. Dietary data were collected from first 600 enrolled prospective cohort study carried out Alberta, Canada. During and/or second trimester, third trimester 3 months postpartum, 24 h recall collected. A...
Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Pemt−/− mice fed a high-fat diet are protected from obesity and whole-body insulin resistance. However, develop severe nonalcoholic steatohepatitis (NASH). Because NASH often associated with resistance, we investigated whether the increased sensitivity was restricted to nonhepatic tissues or liver also sensitive. Strikingly, livers of compared those Pemt+/+ were not...
A water-soluble DSP toxin Dinophysistoxin-4 (DTX-4, 1) is isolated from a butanol-soluble fraction of P. lima strain, and its structure characterized on the basis spectral analysis chemical reactions.