A5007517077- Gut microbiota and health
- Diet and metabolism studies
- Food composition and properties
- Nutritional Studies and Diet
- Clostridium difficile and Clostridium perfringens research
- Genetic Syndromes and Imprinting
- Gastrointestinal motility and disorders
- Probiotics and Fermented Foods
- Clinical Nutrition and Gastroenterology
- Obesity, Physical Activity, Diet
- Adolescent and Pediatric Healthcare
- Microbial Metabolites in Food Biotechnology
- Childhood Cancer Survivors' Quality of Life
- Pancreatic function and diabetes
- Inflammatory Bowel Disease
- Microscopic Colitis
- Child Nutrition and Feeding Issues
- Digestive system and related health
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Food Security and Health in Diverse Populations
- Dietary Effects on Health
- Nutrition and Health in Aging
- Diabetes and associated disorders
- Nutrition, Genetics, and Disease
University of Alberta
2016-2025
University of Nebraska–Lincoln
2023-2025
Edward Hines, Jr. VA Hospital
2014
Auricularia auricula is a well-known traditional edible and medical fungus with high nutritional pharmacological values, as well metabolic immunoregulatory properties. Nondigestible fermentable polysaccharides are identified primary bioactive constituents of extracts. However, the exact mechanisms underlying effects (AAP) on obesity related endpoints, including role gut microbiota, remain insufficiently understood.The AAP were assessed within high-fat diet (HFD)-based mice through trait...
Industrialization adversely affects the gut microbiome and predisposes individuals to chronic non-communicable diseases. We tested a restoration strategy comprising diet that recapitulated key characteristics of non-industrialized dietary patterns (restore diet) bacterium rarely found in industrialized microbiomes (Limosilactobacillus reuteri) randomized controlled feeding trial healthy Canadian adults. The restore diet, despite reducing diversity, enhanced persistence L. reuteri strain from...
Abstract Background and Aims Cirrhosis is associated with dysbiosis, but its functional consequences are still largely unknown. Short‐chain fatty acids (SCFAs) account for physiological interactions between the gut microbiota host. Our aim was to assess impact of cirrhotic dysbiosis on production SCFAs. Methods Seventeen patients cirrhosis 17 controls were selected. Microbiota composition in faecal samples assessed by next‐generation 16S rRNA gene sequencing. SCFAs measured GC‐MS after vitro...
Abstract Background Variability in the health effects of dietary fiber might arise from inter-individual differences gut microbiota’s ability to ferment these substrates into beneficial metabolites. Our understanding what drives this individuality is vastly incomplete and will require an ecological perspective as microbiomes function complex inter-connected communities. Here, we performed a parallel two-arm, exploratory randomized controlled trial 31 adults with overweight class-I obesity...
Dietary fiber is an integral part of a healthy diet, but questions remain about the mechanisms that underlie effects and causal contributions gut microbiota. Here, we performed 6-week exploratory trial in adults with excess weight (BMI: 25-35 kg/m2) to compare high-dose (females: 25 g/day; males: 35 g/day) supplement fermentable corn bran arabinoxylan (AX; n = 15) microbiota-non-accessible microcrystalline cellulose (MCC; 16). Obesity-related surrogate endpoints biomarkers host-microbiome...
Microbial-based therapeutics in clinical practice are of considerable interest, and a recent study demonstrated fecal microbial transplantation (FMT) followed by dietary fiber supplements improved glucose homeostasis. Previous evidence suggests that donor recipient compatibility FMT protocol key determinants, but little is known about the involvement specific factors. Using data from our randomized placebo-control phase 2 trial adults with obesity metabolic syndrome, we grouped participants...
Abstract Background and Aims Crohn’s disease [CD] is associated with alterations in gut microbial composition function. The present controlled-intervention study investigated the relationship between patterns of dietary intake baseline microbiota CD patients remission examined effects a intervention consuming non-diversified diet [NDD]. Methods Forty outpatients quiescent were recruited Calgary, Alberta, Canada. Based on 3-day food records, lower plant-based higher red processed meat-based...
While increased fiber intake may benefit appetite and metabolism in the general population, its effects individuals with Prader-Willi Syndrome (PWS), a condition characterized by hyperphagia, obesity metabolic dysregulation, remain to be explored. This study assessed of intervention on health, gut microbiota PWS, explored associations between changes health markers shifts microbiota. Participants received either high-dose (35g/day) or control for 3 weeks. Following washout period 4 8 weeks,...
The gut microbiome is hypothesized to play a crucial role in the development of obesity and insulin resistance (IR); pathways linking IR pediatrics have yet be precisely characterized. We aimed determine relationship between composition metabolic functions children with obesity. In cross-sectional study, fecal samples from (10–16 years old) were collected for taxonomical functional analysis using shotgun metagenomics. homeostatic model assessment (HOMA-IR) was determined fasting glucose...