A5016750191- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cancer-related cognitive impairment studies
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Blood groups and transfusion
- DNA Repair Mechanisms
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Glioma Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Erythrocyte Function and Pathophysiology
- Genomics and Rare Diseases
- Radiation Therapy and Dosimetry
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
The University of Texas MD Anderson Cancer Center
2022-2025
Washington University in St. Louis
2021-2022
Barnes-Jewish Hospital
2020
Gliomas are the most common primary brain tumor in adults. Current treatments involve surgery, radiation, and temozolomide (TMZ) chemotherapy; however, prognosis remains poor new approaches required. Circadian medicine aims to maximize treatment efficacy and/or minimize toxicity by timed delivery of medications accordance with daily rhythms patient. We published a retrospective study showing greater anti-tumor for morning, relative evening, administration TMZ patients glioblastoma. conducted...
Abstract Background The treatment of relapsed and/or refractory (R/R) acute myeloid leukemia (AML) remains challenging because poor responses to chemotherapy. Efforts improve outcomes have included the use high‐dose cytarabine in combination with nucleoside analogs, such as cladribine. authors evaluated combined cladribine, idarubicin, and (CLIA) a phase 2 trial 66 patients R/R AML. Methods Patients received induction cladribine 5 mg/m intravenously (days 1–5), 1000 idarubicin 10 1–3; CLIA)....
Risk factors for mortality and MDR-TB in Guatemala are poorly understood. We aimed to identify risk assist targeting public health interventions.We performed a retrospective study of adults with pulmonary TB reported the Guatemalan Program between January 1, 2016 December 31, 2017. The primary objective was determine TB. secondary associated MDR-TB.Among 3,945 patients TB, median age 39 years (IQR 25-54), 59% were male, 25% indigenous ethnicity, 1.1% had 3.9% died. On multivariable analysis,...
e14525 Background: High grade gliomas (HGG) (the most common being glioblastoma) are the primary CNS malignancy in adults. Mainstay of therapy is surgical resection followed by concurrent radiation and temozolomide (TMZ) adjuvant TMZ. Unfortunately, prognosis remains poor optimization current critical. Chronotherapy defined as improvement treatment outcomes maximizing efficacy minimizing toxicity administering medications accordance with biological rhythms patient. In a mouse model, there...
Background: Wilms Tumor 1 (WT1) is integral to cell proliferation and survival in acute myeloid leukemia (AML). WT1 mutated (WT1m) 10-15% of patients (pts) with AML associated poorer overall relapse free-survival. WT1m frequently co-occur mutations fms-like 3 (FLT3m) nucleophosmin (NPM1m) abrogate the favorable impact NPM1m pts treated traditional high-intensity chemotherapy. The setting recently approved treatments for (e.g., venetoclax; VEN) remains unknown. Aims: We aim describe...