A5091476107- Immune Response and Inflammation
- Sphingolipid Metabolism and Signaling
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Phagocytosis and Immune Regulation
- Antimicrobial Peptides and Activities
- Protein Tyrosine Phosphatases
- Heme Oxygenase-1 and Carbon Monoxide
- Multiple Sclerosis Research Studies
- S100 Proteins and Annexins
- Adenosine and Purinergic Signaling
- Inflammasome and immune disorders
- Liver physiology and pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Drug Transport and Resistance Mechanisms
Sungkyunkwan University
2012-2024
Boston Children's Hospital
2023
Inflammatory cytokines are fundamental mediators of the organismal response to injury, infection, or other harmful stimuli. To elucidate early and mostly direct transcriptional signatures inflammatory cytokines, we profiled all immunologic cell types by RNAseq after systemic exposure IL1β, IL6, TNFα. Our results revealed a significant overlap in responses, with broad divergence between myeloid lymphoid cells, but very few cell-type-specific responses. Pathway motif analysis identified...
Neutrophils play a key role in innate immunity, and the identification of new stimuli that stimulate neutrophil activity is very important issue. In this study, we identified three novel peptides by screening synthetic hexapeptide combinatorial library. The GMMWAI, MMHWAM, MMHWFM caused an increase intracellular Ca2+ concentration-dependent manner via phospholipase C human neutrophils. acted specifically on neutrophils monocytes not other non-leukocytic cells. As physiological characteristic...
We investigated the effect of lysophosphatidic acid (LPA) in experimental acetaminophen (APAP)-induced acute liver injury. LPA administration significantly reduced APAP-challenged injury, showing attenuated damage, cell death and aspartate aminotransferase alanine levels. APAP overdose-induced mortality was also decreased by administration. Regarding mechanism involved LPA-induced protection against increased glutathione level, which markedly challenge-induced strongly blocked...
Abstract The inflammasome is a specialized multiprotein oligomer that regulates IL-1β production. Although regulation of the related to crucial inflammatory disorders such as sepsis, pharmacological inhibitors effectively inhibit activity are limited. Here, we evaluated effects phospholipase D1 (PLD1)-selective inhibitor (VU0155069) against sepsis and activation. VU0155069 strongly enhances survival rate in cecal ligation puncture (CLP)-induced by inhibiting lung inflammation, leukocyte...
We examined the role of phospholipase D2 (PLD2) on acetaminophen (APAP)-induced acute liver injury using a PLD2 inhibitor (CAY10594). 500 mg/kg APAP challenge caused damage. CAY10594 administration markedly blocked in dose-dependent manner, showing almost complete inhibition with 8 CAY10594. During pathological progress injury, GSH levels are decreased, and this is significantly recovered upon at 6 hours post challenge. GSK-3β (Serine 9)/JNK phosphorylation mainly involved APAP-induced...
Sphingosylphosphorylcholine (SPC) is one of sphingomyelin-derived sphingolipids. SPC levels are increased in ascitic fluids ovarian cancer patients and stratum corneum atopic dermatitis (AD) patients. has antitumor activity against several cells by reducing proliferation migration increasing apoptosis
Introduction Multiple sclerosis (MS) is a potentially disabling disease that damages the brain and spinal cord, inducing paralysis of body. While MS has been known as T-cell mediated disease, recent attention drawn to involvement B cells in its pathogenesis. Autoantibodies from are closely related with damage lesion central nervous system worse prognosis. Therefore, regulating activity antibody secreting cell could be severity symptoms. Methods Total mouse were stimulated LPS induce their...
Abstract The effect of lysophosphatidic acid (LPA) against experimental acetaminophen (APAP)-induced acute liver injury was investigated. LPA administration elicited strongly protective effects APAP-challenged injury, showing attenuated damage, cell death, and AST ALT levels. APAP overdose-induced mortality also significantly by administration. On the mechanism involved in LPA-induced protection not only markedly increased glutathione level but blocked challenge-elicited phosphorylation JNK,...