A5081843087- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Cancer Cells and Metastasis
- Drug Transport and Resistance Mechanisms
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Cytokine Signaling Pathways and Interactions
- Proteoglycans and glycosaminoglycans research
- Pharmacological Effects and Toxicity Studies
- Estrogen and related hormone effects
- Genomics, phytochemicals, and oxidative stress
- PI3K/AKT/mTOR signaling in cancer
- HER2/EGFR in Cancer Research
- Transplantation: Methods and Outcomes
- Skin Protection and Aging
- Dyeing and Modifying Textile Fibers
- Pediatric Hepatobiliary Diseases and Treatments
- Food Quality and Safety Studies
- Antibiotics Pharmacokinetics and Efficacy
- Cancer, Stress, Anesthesia, and Immune Response
- Glutathione Transferases and Polymorphisms
- Drug-Induced Hepatotoxicity and Protection
- Phytoestrogen effects and research
- Nutrition, Genetics, and Disease
Seoul National University
2010-2022
Abstract Cancer‐associated fibroblasts (CAFs) constitute a major compartment of the tumor microenvironment. In present study, we investigated role for CAFs in breast cancer progression and underlying molecular mechanisms. Human MDA‐MB‐231 cells treated with CAF‐conditioned media manifested more proliferative phenotype, as evidenced by enhanced messenger RNA (mRNA) expression Cyclin D1, c‐Myc, proliferating cell nuclear antigen. Analysis data from The Cancer Genome Atlas revealed that...
Pulmonary hypertension is a common but often overlooked complication associated with thalassemia syndromes. There are limited data on the safety and efficacy of selective pulmonary vasodilators in this at-risk population. We, therefore, designed 12-week, open-label, phase 1/2, pilot-scale, proof-of-principle trial sildenafil therapy 10 patients β-thalassemia at increased risk based an elevated tricuspid regurgitant jet velocity >2.5 m/s Doppler-echocardiography. Variables compared baseline...
Sirtuin 1 (SIRT1), an NAD+ -dependent histone/protein deacetylase, has multifaceted functions in various biological events such as inflammation, aging, and energy metabolism. The role of SIRT1 carcinogenesis, however, is still under debate. Recent studies have indicated that aberrant overexpression correlated with metastasis poor prognosis several types malignancy, including colorectal cancer. In the present study, we found both phosphorylated on serine 27 were coordinately upregulated colon...
BRCA1 mutated breast cancer cells exhibit the elevated cell proliferation and higher metastatic potential. G protein-coupled receptor 30 (GPR30) has been shown to regulate growth of hormonally responsive cancers, such as ovarian high expression GPR30 is found in estrogen (ER)-negative cells. ER-negative patients often have a mutation tumor suppressor gene, BRCA1. This study explored antiproliferative effects genistein, chemopreventive isoflavone present legumes, underlying molecular...
Cancer-associated fibroblasts (CAFs) represent a major component of the tumor microenvironment and interplay with cancer cells by secreting cytokines, growth factors extracellular matrix proteins. When estrogen receptor-negative breast MDA-MB-231 were treated CAF-conditioned medium (CAF-CM), Akt STAT3 involved in cell proliferation survival activated through phosphorylation. CAFs secrete fibroblast factor 2 (FGF2), thereby stimulating progression. activation induced CAF-CM was abolished when...
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a representative J-series cyclopentenone prostaglandin, has biphasic roles in cell proliferation and apoptosis. Hypoxia inducible factor-1 (HIF-1) regulates expression of various genes involved tumor growth angiogenesis. In the present study, treatment human breast cancer (MCF-7) cells with 15d-PGJ2 resulted accumulation α-subunit HIF-1. Pretreatment zinc protoporphyrin IX, pharmacological inhibitor heme oxygenase-1 (HO-1), as well siRNA knockdown...
J.H. Suha, H.E. Kangb, I.S. Yoona, S.H. Yangc, Kimd, H.J. Leee, C.-K. Shima & M.G. Lee*a College of Pharmacy and Research Institute Pharmaceutical Sciences, Seoul National University, Seoul, South Koreab Pharmacy, The Catholic University Korea, Bucheon, Koreac Department Pathology Lab Medicine, School North Carolina at Chapel Hill, NC, USAd Dentistry Oral Science, Gangneung-Wonju Gangneung, Koreae Hopkins Bio Center, Korea
1. Zinc acexamate (ZAC) is ionized to zinc and epsilon-acetamidocaproic acid (AACA). Thus, the pharmacokinetics tissue distribution of AACA after intravenous (50 mg kg(-1)) oral (100 administration ZAC were evaluated in rats. Also (10, 20, 30, 50 (20, 50, 100 first-pass extractions at a dose 20 kg(-1) 2. After (20 kg(-1)), approximately 0.408% was not absorbed, F value 47.1%, hepatic gastrointestinal (GI) 8.50% 46.4% dose, respectively. The incomplete mainly due considerable GI extraction 3....
Abstract Cancer-associated fibroblasts (CAFs) constitute a major compartment of the tumor microenvironment. CAFs produce variety cytokines, growth factors and extracellular matrix proteins, thereby stimulating progression. are distinct from normal for their overexpression α-smooth muscle actin fibroblast specific protein-1. Recent studies suggest that play an important role in proliferation migration cancer cells through crosstalk with them.In present study, we investigated breast underlying...
After both the intravenous and oral administration of zinc acexamate [ZAC; ion-pairing between ϵ-acetamidocaproic acid (AACA)] cimetidine together, areas under curve (AUCs) AACA were significantly greater [by 28.2 98.9% after administration, respectively, for control rats 13.5 16.9% indomethacin-induced acute gastric ulcer (IAGU) rats, respectively] than those ZAC alone due to slower renal clearance (CL(R)). The AUCs together in IAGU could have been inhibition active tubular secretion by...
Cancer-associated fibroblasts (CAFs) constitute a major compartment of the tumor microenvironment. CAFs are distinct from normal for their overexpression α-smooth muscle actin (α-SMA) and fibroblast activating protein. Recent studies suggest that play an important role in proliferation migration cancer cells through crosstalk with them. In present study, we investigated breast progression underlying molecular mechanisms. We found increased expression α-SMA human tissues compared adjacent...
Abstract In inflammation-associated carcinogenesis, cyclooxygenase-2 (COX-2) is markedly overexpressed, resulting in accumulation of various prostaglandins. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) and prostahlandin E2 (PGE2) are the predominant COX-2-derived prostaglandins (PGs) with oncogenic potential. present study, we examined effects these to PGs on epithelial-to-mesenchymal transition (EMT), a process by which epithelial cells lose their cell polarity cell-cell adhesion, gain...
Abstract Cancer-associated fibroblasts (CAFs) constitute a major compartment of the tumor microenvironment. CAFs are distinct from normal for their overexpression α-smooth muscle actin (α-SMA) and fibroblast activating protein. Recent studies suggest that play an important role in proliferation migration cancer cells through crosstalk with them. In present study, we investigated breast progression underlying molecular mechanisms. We found increased expression α-SMA human tissues compared...