A5100617444- Lung Cancer Research Studies
- Musculoskeletal pain and rehabilitation
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Environmental remediation with nanomaterials
- Hepatocellular Carcinoma Treatment and Prognosis
- Cloud Data Security Solutions
- Patient Dignity and Privacy
- Caveolin-1 and cellular processes
- Sirtuins and Resveratrol in Medicine
- Motor Control and Adaptation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- Chromium effects and bioremediation
- Eosinophilic Disorders and Syndromes
- Signaling Pathways in Disease
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Oral health in cancer treatment
- Vitamin C and Antioxidants Research
- Orthodontics and Dentofacial Orthopedics
Seoul National University
2008-2024
Kyung Hee University
2024
UCLouvain Saint-Louis Brussels
2024
Bridge University
2024
Yonsei University
2011-2024
Samsung (South Korea)
2023
Seoul National University Hospital
2008-2018
Korean Red Cross
2017-2018
Seoul St. Mary's Hospital
2015
Catholic University of Korea
2015
Remarkable Tumor Response to Crizotinib in a 14-Year-Old Girl With ALK-Positive Non-Small-Cell Lung CancerCase Report A 14-year-old girl presented July 2010 with weight loss (12 kg over 6 months), intermittent fever, night sweats, mild sputum, and cough.She was initially treated for pneumonia community hospital.Because her symptoms did not improve despite the treatment pneumonia, she underwent chest computed tomography (CT) scan, which showed enlargement of multiple lymph nodes lung mass...
Studies about the biology, treatment pattern, and outcome of metastatic/recurrent neuroendocrine tumor (NET) have been few.We enrolled patients with NET diagnosed between January 1996 July 2007 retrospectively analyzed.A total 103 were evaluated. Twenty-six (25.2%) had pancreatic NET, 27 (26.2%) gastrointestinal 2 (1.9%) lung 28 (27.2%) from other sites, 20 (19.4%) unknown origin. The liver was most common metastatic site (68.9%). Thirty-four grade 1 disease, (1.0%) 15 (14.6%) 3 9 (8.7%)...
This study aimed to comprehensively evaluate psychosocial risk factors associated with suicidality in patients schizophrenia Korea.The sample consisted of 84 hospitalized schizophrenia. Suicidal thoughts and a clear desire be dead within 2 weeks were defined as current suicidal ideation. Socio-demographic clinical variables, including family history completed suicides psychiatric illnesses, collected, the Positive Negative Syndrome Scale (PANSS), Calgary Depression for Schizophrenia (CDSS),...
Summary This study was performed to determine the incidence, risk factors, and prognostic implications of venous thromboembolism (VTE) in Asian patients with colorectal cancer (CRC). Differences clinical characteristics impact between extremity thrombosis (or deep-vein thrombosis; DVT)/pulmonary embolism (PE) intra-abdominal (IVT) were also evaluated. For this study, consecutive CRC (N = 2,006) enrolled analyses conducted retrospectively. VTEs classified into two categories (DVT/PE IVT)....
Context: To improve trunk stability or muscle strength, many athletic trainers and physiotherapists use various types of unstable equipment for training. The round foam roll is one those pieces may be useful improving stability. Objective: assess the effect supporting surface (floor versus roll) on activity abdominal muscles during a single-legged hold exercise performed in hook-lying position floor roll. Design: Crossover study. Setting: University research laboratory. Patients Other...
Purpose The purpose of this study was to evaluate the relationships between resistance anaplastic lymphoma kinase (ALK)‒positive non-small cell lung cancer (NSCLC) ALK inhibitors and programmed death-1/programmed death–ligand 1 (PD-L1) pathway, we evaluated alterations in PD-L1 following acquisition ALK-positive cancer. Materials Methods We established inhibitor-resistant lines (H3122CR1, LR1, CH1) by exposing parental H3122 ALK-translocated NSCLC line inhibitors. Then, double-resistant...
Sirtuin 1 (SIRT1), an NAD+ -dependent histone/protein deacetylase, has multifaceted functions in various biological events such as inflammation, aging, and energy metabolism. The role of SIRT1 carcinogenesis, however, is still under debate. Recent studies have indicated that aberrant overexpression correlated with metastasis poor prognosis several types malignancy, including colorectal cancer. In the present study, we found both phosphorylated on serine 27 were coordinately upregulated colon...
Importance Trastuzumab has been the standard of care for treatment patients with ERBB2-positive breast cancer; however, cardiac events have reported. This long-term follow-up study provides clinical evidence supporting similarity a trastuzumab biosimilar (SB3) to reference (TRZ). Objective To compare safety and efficacy between SB3 TRZ early or locally advanced cancer after up 6 years follow-up. Design, Setting, Participants prespecified secondary analysis randomized trial, conducted from...
Neuroendocrine tumor originates from several sites. This study was conducted to reveal the differences in clinical course of neuroendocrine tumors by origin.We reviewed data patients diagnosed with between January 1996 and July 2007.A total 371 were enrolled [pancreas 60, gastrointestinal (GI) tract 210, lung 35, other sites 46, unknown primary 20]. The site correlated stage (P=0.000) grade (P=0.000). At diagnosis, metastasis observed 28.3%, 6.7%, 2.9% cases pancreatic, GI, pulmonary tumors,...
In Korea, the Hospice, Palliative Care, and Life-sustaining Treatment Decision-making Act was enacted in February 2016 order to ensure that patient's self-determination end-of-life care processes is respected. To enhance physicians' understanding of this act provide proper criteria for medical judgment variety clinical settings, consensus guidelines were published November 2016. article, characteristics these related issues regarding definitions 'the end stage disease' 'last days life' are...
This study was performed to investigate the compliance, safety, dosage modifications (dose reduction and/or schedule change [including permanent S-1 withdrawal]), and clinical parameters that predict modification in gastric cancer patients receiving adjuvant chemotherapy. One hundred forty-nine who underwent curative D2 surgery received chemotherapy were enrolled. administered orally (40 mg/m(2) twice daily on days 1-28 every 6 weeks) for 1 year. For unable tolerate S-1, reduced or changed a...
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) has been frequently overexpressed in many types of malignancy, suggesting its oncogenic function. It recognizes phosphorylated serine or threonine (pSer/Thr) a target protein and isomerizes the adjacent proline (Pro) residue, thereby altering folding, subcellular localization, stability, function proteins. The transcription factor, Nrf2 harbors pSer/Thr-Pro motif. This prompted us to investigate whether Pin1 could bind influence...
<title>Abstract</title> This study presents a novel technique for the direct 3D printing of TC-85, biocompatible material specifically designed orthodontic uses. method aims to overcome biomechanical constraints associated with conventional thermoforming process used in aligner fabrication. The investigation emphasizes analyzing TC-85's mechanical and viscoelastic properties, focusing on how temperature changes impact these characteristics their relevance clinical outcomes. Using Digital...
[Purpose] The purpose of this study was to examine the effects lumbopelvic neutralization on angle knee extension, motion, and electromyographic (EMG) activities quadriceps, hamstrings, rectus abdominis muscles subjects with hamstring shortness during seated extension. [Subjects] Twenty young (14 men, 6 women) were recruited for study. [Methods] A pressure biofeedback unit used monitor extension neutralization. EMG activity kinematic data measured without Surface measuring muscle muscles....
Wernicke's encephalopathy (WE) caused by thiamine deficiency is an acute neurological disorder. Clinically, the classic triad of WE consists ophthalmoplegia, ataxia, and mental status changes. Thiamine known to occur commonly in chronic alcoholic patients. Sometimes, it can patients after gastrointestinal surgery those with malabsorption. In addition, undergoing renal dialysis, suffering from hyperemesis gravidarum, receiving total parenteral nutrition (TPN), being treated chemotherapeutic...
We report a case of breast cancer with osteolytic skull lesions which mimicked in multiple myeloma. A 60-year-old female was admitted to our hospital due confused mentality. Laboratory tests showed the findings an increased calcium level, kidney failure, and anemia. Multiple were detected ribs, spine, humerus, pelvis on X-rays. The punched out sign. Accordingly we initially suspected myeloma; however, monoclonal protein not serum urine number plasma cells bone marrow examination. In...
7523 Background: To assess the role of mutant EGFR and C-MET in survival benefit obtained from platinum-based adjuvant chemotherapy (PBAC) among resected lung adenocarcinoma (RLADC) patients. Methods: From 2005 through 2013, RLADC patients (stage IB-IIIA) receiving either PBAC (Paclitaxel/Carboplatin, Paclitaxel/Cisplatin, or Vinorelbine/Cisplatin) to be observed were enrolled. We did immunohistochemistry (IHC) study with EGFR-specific antibody (mutEGFR-sAb) tissue microarray 301 cases....
Antiphospholipid syndrome (APS) is an autoimmune disease that involves vascular thrombosis and pregnancy morbidity associated with elevated titers of antiphospholipid antibodies.APS can affect any organ has a variety clinical manifestations.Infections be thrombotic events in APS, including the potentially fatal subset catastrophic APS.We report case extensive symmetrical peripheral gangrene complicating Escherichia coli sepsis antibodies patient lupus nephritis.(