A5053947052- Chemotherapy-induced cardiotoxicity and mitigation
- Mitochondrial Function and Pathology
- Respiratory Support and Mechanisms
- Cancer Treatment and Pharmacology
- Cardiovascular and exercise physiology
- Muscle Physiology and Disorders
- Electron Spin Resonance Studies
- Neuroscience of respiration and sleep
- Spinal Cord Injury Research
- Cardiovascular Effects of Exercise
- Diabetic Foot Ulcer Assessment and Management
- Cancer survivorship and care
- Exercise and Physiological Responses
- Calcium signaling and nucleotide metabolism
- Chemotherapy-related skin toxicity
- Cardiac Arrest and Resuscitation
- Electrospun Nanofibers in Biomedical Applications
- Sirtuins and Resveratrol in Medicine
- Parkinson's Disease Mechanisms and Treatments
- Atrial Fibrillation Management and Outcomes
- Genetics and Physical Performance
- Analytical Chemistry and Sensors
- Fluorine in Organic Chemistry
- ATP Synthase and ATPases Research
- Cardiac Health and Mental Health
University of Colorado Anschutz Medical Campus
2025
University of Florida
1997-2024
Abstract Acute hyperbaric O 2 (HBO) therapy after spinal cord injury (SCI) can reduce inflammation and increase neuronal survival. To our knowledge, it is unknown if these benefits of HBO require vs. normobaric hyperoxia. We used a C4 lateralized contusion SCI in adult male female rats to test the hypothesis that combination hyperbaria 100% (i.e. HBO) more effectively mitigates loss, enhances respiratory recovery, as compared . Experimental groups included intact, no therapy, + delivered at...
Trong nhiều thập kỷ, các nhà quản lý ngân hàng đã tập trung vào việc ra quyết định cho vay cẩn trọng và giám sát kỹ lưỡng sau khi nhằm rủi ro danh mục vay. Tuy nhiên, liên quan đến trong thương mại (NHTM) chỉ rằng công cụ hiện tại chưa đủ để đối phó với những hệ thống gia tăng nền kinh tế. Trước đây, thường báo như nợ quá hạn, dưới chuẩn, hay xếp hạng tín dụng, nhưng này không giúp hành động kịp thời trước dụng. Do đó, hiệu quả yêu cầu kiểm soát chất lượng khoản mà còn đòi hỏi sự phát triển...
Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, an unintended consequence of prolonged MV the rapid development diaphragmatic atrophy and contractile dysfunction, known as ventilator-induced diaphragm dysfunction (VIDD). Although mechanism(s) responsible VIDD are not fully understood, abundant evidence reveals that oxidative stress leading to activation major proteolytic systems (i.e., autophagy, ubiquitin-proteasome, caspase,...
Doxorubicin (DOX) is a chemotherapeutic agent highly effective at limiting cancer progression. Despite the efficacy of this anticancer drug, clinical use DOX limited due to cardiotoxicity. The cardiac mitochondria are implicated as primary target DOX, resulting in inactivation electron transport system complexes, oxidative stress, and iron overload. However, it established that mitochondrial subpopulations reveal differential responses exposure, with subsarcolemmal (SS) demonstrating redox...
Doxorubicin (DOX) is a highly effective chemotherapeutic agent used in the treatment of various cancer types. Nevertheless, it well known that DOX promotes development severe cardiovascular complications. Therefore, investigation into underlying mechanisms drive DOX-induced cardiotoxicity necessary to develop therapeutic countermeasures. In this regard, autophagy complex catabolic process increased heart following exposure. However, conflicting evidence exists regarding role dysregulation...
Doxorubicin (DOX) is a highly effective anthracycline antibiotic used to treat wide variety of cancers including breast cancer, leukemia and lymphoma. Unfortunately, clinical use DOX limited due adverse off-target effects resulting in fatigue, respiratory muscle weakness dyspnea. The diaphragm the primary inspiration insufficiency likely result both neural impairment. However, contribution neuropathology DOX-induced dysfunction unclear. We hypothesized that following acute exposure...
Abundant evidence reveals that activation of the renin-angiotensin system promotes skeletal muscle atrophy in several conditions including congestive heart failure, chronic kidney disease, and prolonged mechanical ventilation. However, controversy exists about whether circulating angiotensin II (AngII) by direct or indirect effects; centerpiece this debate is issue fibers express AngII type 1 receptors (AT1Rs). While some investigators assert expresses AT1Rs, others argue do not contain...
Cardiorespiratory dysfunction resulting from doxorubicin (DOX) chemotherapy treatment is a debilitating condition affecting cancer patient outcomes and quality of life. DOX promotes cardiac respiratory muscle pathology due to enhanced reactive oxygen species (ROS) production, mitochondrial impaired contractility. In contrast, hyperbaric (HBO) therapy considered controlled oxidative stress that can evoke substantial sustained increase in antioxidant expression. This HBO-induced capacity has...
Mechanical ventilation (MV) is a life-saving instrument used to provide ventilatory support for critically ill patients and undergoing surgery. Unfortunately, an unintended consequence of prolonged MV the development inspiratory weakness due both diaphragmatic atrophy contractile dysfunction; this syndrome labeled ventilator-induced diaphragm dysfunction (VIDD). VIDD clinically important because contributor problems in weaning from MV. Investigations into pathogenesis reveal that oxidative...
Doxorubicin (DOX) is a highly effective chemotherapeutic agent. Unfortunately, cancer patients who have completed DOX treatment often experience exercise intolerance, reduced cardiac function, dyspnea and unfavorable changes to body composition, ultimately, leading increased incidence of heart failure. Exercise has been shown reduce the risk developing chemotherapy-induced cardiorespiratory dysfunction; however, ability during can be limited by type, stage fatigue. Therefore, these...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic arrhythmic syndrome caused by mutations in the calcium (Ca
Đặt vấn đề: Sự cố liên quan đến thuốc là một trong những nguyên nhân gây tổn thương người bệnh, tuy nhiên đây lỗi có thể tránh được. Việc đánh giá tình hình kê đơn sẽ giúp cơ sở nhận thấy các đề đang tồn đọng, từ đó biện pháp nhằm nâng cao hiệu quả sử dụng thuốc. Mục tiêu nghiên cứu: Khảo sát ngoại trú tại Bệnh viện đa khoa Vùng Tây Nguyên năm 2022. Đối tượng và phương Mô tả cắt ngang trên 420 được Kết quả: ghi thông tin tên chẩn đoán của bác sĩ đều đạt 100%, về địa chỉ bệnh 31,7%. Thông...
Doxorubicin (DOX) is a highly effective chemotherapeutic agent used to treat variety of solid tumor malignancies including breast cancer. However, following DOX treatment cancer patients often suffer from reduced cardiorespiratory capacity and weight gain with increased body fat. These adverse changes increase the risk developing cardiovascular disease, thus, increasing patient mortality. In this regard, exercise has been shown be in improving composition. Therefore, using clinically...
Doxorubicin (DOX)-induced cardiotoxicity results in an increased risk of mortality among chemotherapy recipients. Cardiomyocyte dysfunction is caused by the off-target accumulation DOX cardiac mitochondria, stimulating oxidative damage and impaired phosphorylation. Prior research showed that exercise preconditioning may prevent DOX-induced enhancing abundance mitochondrial ATP-binding cassette (ABC) transporters, potentially accelerating rate clearance from cardiomyocytes. Mitochondrial ABC...
Doxorubicin (DOX) is a highly effective chemotherapeutic agent used in the treatment of broad spectrum human cancers. However, clinical use DOX limited due to dose-dependent cardiotoxicity, which adversely affects quality life and survival. Therefore, new strategies mitigate cardiotoxic effects are needed improve usefulness long-term health outcomes. The mitochondria-localized ATP-binding cassette (ABC) proteins (i.e. ABCB6, ABCB7, ABCB8 ABCB10) family transporters with potential mediate...
PURPOSE: The clinical use of doxorubicin (DOX) as a chemotherapeutic agent is severely limited by cardiotoxicity. Following treatment, DOX can accumulate within cardiomyocytes leading to mitochondrial dysfunction and heart failure. Interestingly, exercise has been shown limit However, no current study considers sex in this paradigm. METHODS: Adult male female Sprague Dawley rats underwent 2-week treadmill preconditioning program (5 days/week, 60 min/day, 30 m/min, 0% grade). Twenty-four...
Prolonged skeletal muscle inactivity results in fiber atrophy and weakness. Interestingly, endurance exercise training promotes a protective phenotype fibers that resists inactivity‐induced wasting. The mechanism(s) responsible for this exercise‐induced preconditioning of remain unknown are explored these experiments. In regard, evidence reveals activation the classical arm renin‐angiotensin system (RAS) contributes to Specifically, RAS pathway via angiotensin II type I receptor (AT1R) is...