The first example of direct synthesis 2-sulfonylquinolines through visible-light-induced deoxygenative C2-sulfonylation quinoline <italic>N</italic>-oxides with organic dye as the catalyst and ambient air sole oxidant was developed.

An eco-friendly visible-light-induced decarboxylative acylation of quinoxalin-2(1<italic>H</italic>)-ones and α-oxo carboxylic acids with air as the oxidant under external-photocatalyst-free conditions was established.

Without employing any base and organic solvent, an economical, practical eco-friendly protocol has been developed for the ultrasound accelerated one-pot synthesis of various functionalized 2-sulfonylquinolines from easily accessible starting materials in water under open-air conditions.

A efficient and sustainable approach for the synthesis of 3-alkylquinoxalin-2(1H)-ones has been developed through visible-light-mediated decarboxylative alkylation quinoxalin-2(1H)-ones with phenyliodine(III) dicarboxylates. This photocatalytic reaction could be conducted at ambient temperature by employing eco-friendly PEG-200 as medium. Various were easily obtained present ruthenium(II) catalytic system, which successfully recycled five times without significant decrease its efficiency.

The first example of a metal- and reductant-free deoxygenative sulfonylation quinoline <italic>N</italic>-oxides with sodium sulfinates <italic>via</italic> dual radical coupling process is reported.

A facile, practical and environmentally attractive protocol for the direct diversification of N-heterocycles under ambient, metal- base-free conditions was developed.

Without using any base and organic solvent, an environmentally benign methodology was developed for the aqueous synthesis of various functionalized quinolin-2(1H)-ones at ambient temperature. The protocol has a wide substrate scope, excellent to quantitative yields, short reaction time (1–8 min), operational simplicity, reusable medium avoids further chromatographic purification. More importantly, this is markedly greener than traditional routes with E-factor 1.6 eco-scale score 89.5.

A new and efficient visible-light-mediated strategy has been developed for the synthesis of 3-sulfenylated quinoxalin-2(1<italic>H</italic>)-ones <italic>via</italic> rhodamine B catalyzed C–H/S–H cross-coupling with thiols in air at room temperature.

Aryl radicals were generated for the first time from aryl acyl peroxides in ethyl acetate under ambient conditions and visible-light illumination absence of any additive, metal catalyst, or external photosensitizer.

An efficient protocol for the selective synthesis of α-mono or α,α′-dihalo ketones <italic>via</italic> a water-controlled chemodivergent and regiospecific cascade reaction has been developed.

α-Oxo gold carbenes generated via intermolecular oxidation of terminal alkynes are shown to be highly electrophilic and can effectively abstract halogen from halogenated solvents such as 1,2-dichloroethane or 1,2-dibromoethane. Chloro/bromomethyl ketones prepared in moderate efficiencies one step using Ph3PAuNTf2 the catalyst 8-methylquinoline N-oxide oxidant.

An ecofriendly and practical method for the efficient synthesis of various sulfonylated N-heteroaromatics in water under metal-free, organic-solvent-free, neutral, mild reaction conditions was developed. The employment readily available reagents, wide substrate scope, high chemoselectivity, regioselectivity make this protocol very practical. Importantly, pure products can be easily obtained via filtration washing by alcohol without extraction recrystallization.

A general atom-economical approach for the synthesis of α-halomethyl ketones is demonstrated through hydration a wide range haloalkynes. Other outstanding features include excellent yields from both alkyl- and aryl-substituted haloalkynes functional group tolerance. This protocol an alternative to conventional α-halogenation ketones.

Abstract A metal‐, base‐ and reductant‐free approach for the efficient synthesis of various N ‐acylated 2‐aminoquinolines was reported. In this work, readily available nitriles are used as amide source, methyl carbazate both radical activating reagent oxygen source. This is first report on ester‐radical‐activated highly regioselective addition to quinolone ‐oxides. procedure expected complement current methods functionalization ‐oxides via an electrophilic activation mechanism. magnified image

An economic and eco-friendly straightforward synthesis of highly diversified N-acylated 2-aminoquinolines is successfully achieved via Brønsted acidic ionic liquid-promoted amidation quinoline N-oxides with nitriles. The advantage this present process highlighted by its easily accessible starting materials, excellent functional group tolerance, 100% atom economy, operational simplicity, clean reaction profile.

A general, effective and convenient protocol for the direct synthesis of various 2-aminoquinolines (39 examples) through AgBF₄-catalyzed amination quinoline <italic>N</italic>-oxides with isothiocyanates under base-, oxidant-free mild conditions was developed.

An environmentally-friendly method for the clean preparation of various quinolin-2-yl substituted ureas in water under mild and toxic reagent-, base-, organic solvent-free conditions was established. In large-scale synthesis, products could be rapidly collected via simple filtration washing with ethanol. The usage readily available raw materials, 100% atom economy, high yield, excellent regioselectivity enhanced practicability this protocol.

By using ambient air as an oxidant, various N-acylated 3-aminoquinoxalin-2(1H)-ones were efficiently synthesized through visible-light-promoted rhodamine B-catalyzed amidation reaction of quinoxalin-2(1H)-ones and amides under metal-free strong oxidant-free conditions.

A sustainable method for the construction of valuable β-keto sulfones lies in reaction between vinyl azides and alkyl sulfonyl radical generated from low-cost comparatively steady bulk chemical dimethyl sulfoxide (DMSO) that has been developed. This strategy features mild economical conditions using inexpensive NiCl2 as catalyst H2O2 green oxidant. The conversion occurs through a sequence ordered processes consisting addition, denitrogen, hydrogen abstraction, hydrolysis. Mechanistic studies...

Abstract Herein, we present a (NH 4 ) 2 S O 8 mediated difunctionalization reaction of aryl alkenes with quinoxalinones and P(O)SH compounds. This method enables the synthesis various phosphorothioate‐containing quinoxalin‐2(1 H )‐one derivatives (46 examples) in 37–79% yields. The is compatible range functional groups easily adaptable to large‐scale synthesis. Preliminary studies suggest involvement phosphorothioate radicals these transformations.

An economic, safe, practical, and environmentally benign protocol for the oxidation of aldehydes to carboxylic acids acid anhydrides with ambient air as sole oxidant was developed. This is operationally simple external catalyst-, initiator-, base-free, outstanding functional group tolerance (moisture-, acid-, base-, oxidant-sensitive groups). It also provides a practical large scale synthesis (>100 g), late-stage modification polyfunctional compounds, one-pot sequential transformation...

A convenient, efficient and practical approach for the synthesis of

Incorporating a sulfonyl group into parent molecules has been shown to effectively improve their synthetic applications and bioactivities. In this study, we present straightforward practical approach for the ring-opening reaction of alkenyl–aryl sulfonium salts with sodium sulfinates produce range sulfur-containing alkyl sulfones. This method offers benefits mild conditions, easily accessible raw materials, wide substrate applicability, good functional compatibility, operational simplicity....