A5017538641- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Malaria Research and Control
- COVID-19 diagnosis using AI
- Mosquito-borne diseases and control
- Parasite Biology and Host Interactions
- Identification and Quantification in Food
- Viral Infections and Outbreaks Research
- Digital Imaging for Blood Diseases
- Parasites and Host Interactions
- Biosensors and Analytical Detection
- Parasitic Diseases Research and Treatment
- Bacterial Identification and Susceptibility Testing
- Machine Learning in Bioinformatics
- Simulation Techniques and Applications
- Insect Resistance and Genetics
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Yersinia bacterium, plague, ectoparasites research
- Hepatitis B Virus Studies
- Big Data Technologies and Applications
- Computational Drug Discovery Methods
- Amino Acid Enzymes and Metabolism
- Insect Pest Control Strategies
- Entomopathogenic Microorganisms in Pest Control
Wellcome Trust
2020-2024
Kenya Medical Research Institute
2020-2024
Pwani University
2022
<ns7:p><ns7:bold>Background:</ns7:bold> Antimalarial drug resistance is a major obstacle to sustainable malaria control. Here we use amplicon sequencing describe molecular markers of in <ns7:italic>Plasmodium falciparum</ns7:italic> parasites from Kilifi county the coastal region Kenya over 25-year period.</ns7:p><ns7:p> <ns7:bold>Methods:</ns7:bold> We performed <ns7:italic>P. on 1162 malaria-infected blood samples collected between 1994 and 2018 identify antimalarial...
Background. International recommendations for the control of coronavirus disease 2019 (COVID-19) pandemic emphasize central role laboratory testing severe acute respiratory syndrome 2 (SARS-CoV-2), etiological agent, at scale. The availability reagents, equipment and qualified staff are important bottlenecks to achieving this. Elsewhere, pooled (i.e. combining multiple samples in same reaction) has been suggested increase capacities period. Methods. We discuss our experience with SARS-CoV-2...
<ns4:p><ns4:bold>Background.</ns4:bold> International recommendations for the control of coronavirus disease 2019 (COVID-19) pandemic emphasize central role laboratory testing severe acute respiratory syndrome 2 (SARS-CoV-2), etiological agent, at scale. The availability reagents, equipment and qualified staff are important bottlenecks to achieving this. Elsewhere, pooled (i.e. combining multiple samples in same reaction) has been suggested increase capacities period.</ns4:p><ns4:p>...
Abstract Background Estimation of the composition and densities mosquito species populations is crucial for monitoring epidemiology mosquito-borne diseases provide information on local vectors to public health officials policy-makers. The aim this study was evaluate malaria vector bionomics in ecologically distinct sites Taita-Taveta County, Kenya. Methods Adult mosquitoes were collected using backpack aspirators paired indoor/outdoor CDC light traps 10 randomly selected households six...
<ns4:p><ns4:bold>Background:</ns4:bold> The global COVID-19 outbreak relies on a quantitative real-time polymerase chain reaction (qRT-PCR) for the detection of severe acute respiratory syndrome coronavirus (SARS-CoV-2), to facilitate roll-out patient care and infection control measures. There are several qRT-PCR assays with little evidence their comparability. We report alterations developers’ recommendations sustain testing capability in our setting, where supply reagents is...
<ns4:p>Background Protein analysis using matrix-assisted laser desorption/ionisation time-of-flight mass-spectrometry (MALDI-TOF MS) represents a promising tool for entomological surveillance. In this study we tested the discriminative power of measuring species and blood meal source main Afrotropical malaria vectors on Kenyan coast. Methods Mosquito collections were conducted along coastal region Kenya. MALDI-TOF MS spectra obtained from each individual mosquito’s cephalothorax as well...
<ns4:p><ns4:bold>Background:</ns4:bold> The COVID-19 pandemic relies on real-time polymerase chain reaction (qRT-PCR) for the detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), to facilitate roll-out patient care and infection control measures. There are several qRT-PCR assays with little evidence their comparability. We report alterations developers’ recommendations sustain testing capability in a resource-limited setting.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold>...
<ns3:p><ns3:bold>Background:</ns3:bold> Protein analysis using matrix-assisted laser desorption/ionization time-of-flight mass-spectrometry (MALDI-TOF MS) represents a promising tool for entomological surveillance. In this study we tested the discriminative power of measuring species and blood meal source main Afrotropical malaria vectors on Kenyan coast.</ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> Mosquito collections were conducted along coastal region Kenya. MALDI-TOF MS spectra obtained...
Abstract Lymphatic filariasis (LF) is an infectious neglected tropical disease caused by a mosquito-borne nematode and major cause of disability. In 2022, it was estimated that 51 million people were infected with LF. Kenya endemic along the entire coastal strip. The main vectors are Anopheles funestus gambiae in rural areas Culex quinquefaciatus mosquitoes urban areas. collected from Kilifi, Kwale Taita-Taveta counties which located within LF region Kenya. Subsequently, genomic...
Lymphatic filariasis (LF) is an infectious neglected tropical disease caused by mosquito-borne nematodes such as Wuchereria bancrofti, Brugia malayi, and timori. Globally, LF affects 51 million people, with approximately 863 at risk in 47 countries. In Kenya, endemic along the entire coastal strip, more recently, Kenya-Ugandan border. The World Health Organization (WHO) recommends mass drug administration to reduce transmission morbidity. Monitoring effectiveness of interventions relies on...
<title>Abstract</title> This study analyzes the distribution, genetic diversity, and spread of <italic>An. stephensi</italic> in Kenya following initial detection December 2022. A total 114 larval 33 adult samples were confirmed 7 18 surveyed counties majorly along transportation routes. Genetic analyses revealed three distinct compositions with different levels suggesting multiple introductions into country. The composition mosquitoes most resembled southern Ethiopian populations, while...
Abstract Background Malaria remains one of the most important infectious diseases in Sub-Saharan Africa, responsible for approximately 228 million cases and 602,000 deaths 2020. transmission is mainly driven by mosquitoes Anopheles gambiae more recently funestus complex. The gains made malaria control are threatened insecticide resistance behavioural plasticity among these vectors. This, therefore, calls development alternative approaches such as transmission-blocking using gene drive...
Abstract Background Malaria remains one of the most important infectious diseases in sub-Saharan Africa, responsible for approximately 228 million cases and 602,000 deaths 2020. In this region, malaria transmission is driven mainly by mosquitoes Anopheles gambiae and, more recently, funestus complex. The gains made control are threatened insecticide resistance behavioural plasticity among these vectors. This, therefore, calls development alternative approaches such as transmission-blocking...
<h3>Background</h3> The EDCTP_STOP project is a multicentric clinical trial (ALIVE ct.gov: NCT05124691) that aims to interrupt the transmission of soil-transmitted helminths using novel treatment regimens. While cure rate measured by microscopy primary efficacy outcome, limitations in sensitivity after successful pose challenge. Nucleic acid amplification tests are promising alternative. One objective assess real-time polymerase chain reaction (qPCR) as secondary which necessitates...