A5009135747- Sinusitis and nasal conditions
- Cardiac electrophysiology and arrhythmias
- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Gastrointestinal motility and disorders
- Cardiac Arrhythmias and Treatments
- Advancements in Transdermal Drug Delivery
- Bee Products Chemical Analysis
- Reproductive System and Pregnancy
- Drug Solubulity and Delivery Systems
- Heart Rate Variability and Autonomic Control
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Gastroesophageal reflux and treatments
- Head and Neck Surgical Oncology
- Advanced Drug Delivery Systems
- Wireless Power Transfer Systems
- Wound Healing and Treatments
- Innovative Energy Harvesting Technologies
- Sphingolipid Metabolism and Signaling
- Tracheal and airway disorders
- Pressure Ulcer Prevention and Management
- Preterm Birth and Chorioamnionitis
- Microbial Inactivation Methods
- Wireless Body Area Networks
University of Otago
2024
University of Auckland
2011-2023
Lactoferrin is a multifunctional glycoprotein with therapeutic potential for bone tissue engineering. The aim of this study was to assess the efficacy local application lactoferrin on regeneration. Five-millimetre critical-sized defects were created over right parietal in 64 Sprague-Dawley rats. rats randomized into four groups: group 1 (n = 20) had empty defects; 2 grafted collagen gels (3 mg/ml); 3 impregnated bovine (10 μg/gel); and 4 4) sham surgeries (skin periosteal incisions only)....
Background Although chronic rhinosinusitis (CRS) causes very significant morbidity, much about its pathogenesis remains uncertain. Recent studies have identified polymicrobial biofilms on the surface of sinus mucosa and Staphylococcus aureus within patients with CRS, both without nasal polyps. The pathogenic implications intramucosal bacteria in CRS are unknown. This study was designed to determine prevalence species bacterial colonies adult describe relationship these host immune response....
Rotator cuff tears can cause significant pain and functional impairment. Without surgical repair, the rotator has little healing potential, following they are highly prone to re-rupture. Augmenting such repairs with a biomaterial scaffold been suggested as potential solution. Extracellular matrix (ECM)-based scaffolds most commonly used augments, although date, reports on their success variable. Here, we utilize pre-clinical in vitro vivo assays assess efficacy of novel scaffold, ovine...
Abstract Transcutaneous energy transfer (TET) systems use magnetic fields to power across the skin without direct electrical connectivity. This offers prospect of lifetime operation and overcomes risk infection associated with wires passing through skin. Previous attempts at this technology have not proved suitable due poor efficiency, large size, or tissue damage. We developed a novel approach utilizing frequency control that allows for wide tolerance in alignment between internal external...
Gastric motility is coordinated by underlying bioelectrical slow waves. dysrhythmias occur in gastrointestinal (GI) disorders, but there are no validated methods for eliminating dysrhythmias. We hypothesized that targeted ablation could eliminate pacemaker sites the stomach, including dysrhythmic ectopic sites. In vivo high-resolution serosal electrical mapping (16 × 16 electrodes; 6 cm) was applied to localize normal and gastric 13 anesthetized pigs. Radiofrequency performed a square...
Lingual frenotomy has become an increasingly common surgical procedure, performed for a broad range of indications from birth through adulthood. This study utilizes histology to define the structure and tissue composition lingual frenulum floor mouth (FOM) fascia. En bloc specimens anterior tongue, frenulum, FOM tissues were harvested ten embalmed adult cadavers. An additional three fresh cadaveric frozen with tongue supported in elevated position, enable harvesting paraffin embedding as...
Gastric motility is coordinated by underlying bioelectrical "slow wave" activity. Slow wave dysrhythmias are associated with disorders, including gastroparesis, offering an underexplored potential therapeutic target. Although ablation widely used to treat cardiac arrhythmias, this approach has not yet been trialed for gastric electrical abnormalities. We hypothesized that can create localized conduction blocks and modulate slow activation. Radiofrequency was performed on the porcine serosa...
Bacterial biofilms have been identified on the sinonasal mucosa of patients with chronic rhinosinusitis (CRS) but also control samples. Their role in disease pathogenesis is unproven. The objective this study was to further evaluate CRS by assessing whether they are associated an inflammatory response.Mucosal samples were collected from 18 and 7 normal subjects. Bacteria mucosal surface Gram stain. Immune cells Giemsa stain immunohistochemistry (IHC). number local immune recorded beneath...
DNA methyltransferases (DNMTs) and ten-eleven translocation proteins (TETs) facilitate methylation hydroxymethylation of DNA, respectively. DNMTs are widely studied with conflicting results on their regulation in the endometrium. While role TETs endometrium remains relatively unexplored. Deregulated expression associated endometrial pathologies. The aim this study is to characterize temporal TET determine hormonal comparison DNMTs. mRNA expressions were quantified by real-time PCR tissues...
Heart failure is characterized by the loss of sympathetic innervation to ventricles, contributing impaired cardiac function and arrhythmogenesis. We hypothesized that renal denervation (RDx) would reverse this loss. Male Wistar rats underwent myocardial infarction (MI) or sham surgery progressed into heart for 4 wk before receiving bilateral RDx RDx. After additional 3 wk, left ventricular (LV) was assessed, nerve fiber density determined via histology. Post-MI displayed significant...
Contractions of the uterus play an important role in menstruation and fertility, contractile dysfunction can lead to chronic diseases such as endometriosis. However, structure function are difficult interrogate humans, thus animal studies often employed understand its function. In rats, anatomical have typically been based on histological assessment, limited small segments uterine structure, time-consuming reconstruct at organ scale. This study used micro-computed tomography imaging...
We apply three optical coherence tomography (OCT) image analysis techniques to extract morphometric information from OCT images obtained on peripheral nerves of rat. The accuracy each technique is evaluated against histological measurements accurate + / - 1 μm. are: (1) average depth-resolved profile (ADRP), (2) autoregressive spectral estimation (AR-SE), and (3) correlation the derivative (CoD-SE). introduce a scanning window ADRP technique, which provides transverse resolution improves...
Abstract The use of biomaterial scaffolds has been an enormous field research in tissue engineering, where the aim is to graft materials for assisting human body recovering lost functions. Currently, there are many ways can be fabricated; however, these techniques involve toxic organic solvents during process. As biocompatibility one mandatory requirements designing a successful scaffold, interest fabricating that completely solvent‐free. This paper describes development and characterization...
Some patients with chronic rhinosinusitis (CRS) exhibit thickening of the sinus bones that has been termed osteitis. The histopathology and microbiology these changes have not fully described. aim this study was to look for presence bacteria immune cells within samples bone from without CRS correlate findings radiological findings.Bone on anterior face sphenoid examined radiologically histologically in 8 nasal polyposis, 6 control pituitary adenomas normal sinuses. Bone thickness density...
Gastric ablation has demonstrated potential to induce conduction blocks and correct abnormal electrical activity (i.e., ectopic slow-wave propagation) in acute, intraoperative vivo studies. This study aimed evaluate the safety feasibility of gastric modulate after 2 wk healing. Chronic experiments were performed weaner pigs (n = 6). Animals randomly divided into two groups: sham-ablation 3, control group; no power delivery, room temperature, 5 s/point) radiofrequency (RF) 3;...
Prostate cancer (PCa) is a significant healthcare problem worldwide. Current diagnosis and treatment methods are limited by lack of precise in vivo tissue analysis methods. Real-time identification grading could dramatically improve current protocols. Here, we report the testing thin optical probe using Raman spectroscopy (RS) classification to detect grade PCa accurately real-time. We present first clinical trial on fresh ex biopsy cores from an 84 patient cohort. Findings 2395 spectra...
Abstract Discoid lupus erythematosus (DLE) is the most common form of cutaneous 1 . It can cause permanent scarring. The pathophysiology not fully understood. Plasmacytoid dendritic cells are found in close association with apoptotic keratinocytes inferring cellular signalling. Matrix Associated Laser Desorption Ionisation (MALDI) combined Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS) an exquisitely sensitive combination to examine disease processes at and molecular...
Rectal drug administration could offer advantages in the delivery of medicines for children by avoiding swallowability issues, improving stability and enabling caregivers. This study aimed to evaluate rectal bioavailability hollow-type suppositories (HTS) understand effect two chemical forms amoxicillin: amoxicillin sodium (AS) or trihydrate (AMT). HTS were prepared incorporating a lipophilic core containing antibiotic with polyethylene glycol (PEG) shell. Formulations characterised vitro,...