A5029054003- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Bone Tissue Engineering Materials
- Orthopedic Surgery and Rehabilitation
- Sports injuries and prevention
- Shoulder and Clavicle Injuries
- Bone Metabolism and Diseases
- Surgical Sutures and Adhesives
- Electrospun Nanofibers in Biomedical Applications
- Neuropeptides and Animal Physiology
- Osteoarthritis Treatment and Mechanisms
- Infant Nutrition and Health
- Musculoskeletal synovial abnormalities and treatments
- Knee injuries and reconstruction techniques
- Bone health and osteoporosis research
- Bone health and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Bee Products Chemical Analysis
- Hydrogels: synthesis, properties, applications
- Genital Health and Disease
- Neonatal Respiratory Health Research
- Tissue Engineering and Regenerative Medicine
- Proteoglycans and glycosaminoglycans research
- Exercise and Physiological Responses
- Cardiovascular Effects of Exercise
University of Auckland
2015-2024
Universitätsklinikum Aachen
2024
RWTH Aachen University
2024
Paul Gerhardt Diakonie
2015-2020
MacDiarmid Institute for Advanced Materials and Nanotechnology
2020
University of Birmingham
2009
The aim of this study was to gain an understanding on the collective cellular effects magnesium (Mg) corrosion products behaviour cells responsible for bone formation and remodelling. response mesenchymal stem (MSCs) osteoclast both soluble (Mg ions) insoluble (granule) were recapitulated in vitro by controlling concentration products. Clearance granules MSCs also inspected TEM analysis at sub-cellular level. effect Mg varied depending state differentiation cells, length exposure. presence...
Lactoferrin is a multifunctional glycoprotein with therapeutic potential for bone tissue engineering. The aim of this study was to assess the efficacy local application lactoferrin on regeneration. Five-millimetre critical-sized defects were created over right parietal in 64 Sprague-Dawley rats. rats randomized into four groups: group 1 (n = 20) had empty defects; 2 grafted collagen gels (3 mg/ml); 3 impregnated bovine (10 μg/gel); and 4 4) sham surgeries (skin periosteal incisions only)....
Tearing of the rotator cuff tendon in shoulder is a significant clinical problem, with large/full-thickness tears present ∼22% general population and recurrent tear rates postarthroscopic repair being quoted as high 94%. Tissue-engineered biomaterials are increasingly investigated means to augment repairs, aim inducing host cell responses increase tissue regeneration. Silk-derived materials particular interest due availability, mechanical strength, biocompatibility silks. In this study,...
Bone erosion is a frequent complication of gout and strongly associated with tophi, which are lesions comprising inflammatory cells surrounding collections monosodium urate (MSU) crystals. Osteocytes important cellular mediators bone remodeling. The aim this study was to investigate the direct effects MSU crystals indirect crystal-induced inflammation on osteocytes. For assays, were added MLO-Y4 osteocyte cell line cultures or primary mouse cultures. RAW264.7 macrophage cultured without...
Rotator cuff tears can cause significant pain and functional impairment. Without surgical repair, the rotator has little healing potential, following they are highly prone to re-rupture. Augmenting such repairs with a biomaterial scaffold been suggested as potential solution. Extracellular matrix (ECM)-based scaffolds most commonly used augments, although date, reports on their success variable. Here, we utilize pre-clinical in vitro vivo assays assess efficacy of novel scaffold, ovine...
Surgeons have a range of materials to choose from complete wound closure, yet surprisingly very little is still known about the body's immune response suture in current use. The growing literature adverse material reactions provided objective this study, use vitro assays quantify levels inflammation produced by seven commonly used surgical procedures. Human monocyte/macrophage THP-1 cells were exposed for 1, 3 and 5 days. Gene expression protein secretion six inflammatory cytokines two cell...
A positive association between fat and bone mass is maintained through a network of signaling molecules. Clinical studies found that the circulating levels adiponectin, peptide secreted from adipocytes, are inversely related to visceral mineral density, it has been suggested adiponectin contributes coupling bone. Our study tested hypothesis affects tissue by comparing phenotype wild-type adiponectin-knockout (APN-KO) female mice ages 8–37 weeks. Using longitudinal design, we determined body...
ADM (adrenomedullin) has pleiotropic effects, including regulation of inflammation, infection, angiogenesis, mineralized-tissue formation and development. Recently, we demonstrated up-regulation the transcript in diseased pulpal tissue while protein is sequestered within dentine extracellular matrix during dentinogenesis. The present study aimed to characterize localization rodent dental development determine its potential effects on cells. Finally, sought profile levels adult organs tissues...
Bone tissue engineering with cell-scaffold constructs has been attracting a lot of attention, in particular as tool for the efficient guiding new formation. However, majority current strategies used to evaluate novel biomaterials focus on osteoblasts and bone formation, while osteoclasts are often overlooked. Consequently, there is limited knowledge interaction between biomaterials. In this study, ability spongy-like gellan gum hydroxyapatite-reinforced hydrogels support osteoclastogenesis...
Injuries to tendons and ligaments make up a large portion of musculoskeletal injuries, contribute significant morbidity healthcare costs. However, there is currently poor understanding the burden these injuries at population level. The purpose this study was quantify distribution tendon ligament in Aotearoa/New Zealand population.Using Accident Compensation Corporation (ACC, no fault comprehensive compensation scheme encompassing all Zealand; 2013 4.4 million) database, data specific were...
Tranexamic acid (TXA) has been shown to be effective at reducing peri-operative blood loss and haemarthrosis in arthroplasty arthroscopic soft tissue reconstructions. Intra-articular application, as an injection or peri-articular wash, is becoming increasingly common. Recent studies have TXA the potential cytotoxic cartilage, but its effects on human tendon bone remain poorly understood. The aim of this study was investigate whether any detrimental tendon-derived cells osteoblast-like...
Purpose: An underlying connective tissue disorder (CTD) may predispose to formation of intestinal diverticula. We assess the association diverticulosis with nine selected CTDs, inform pathophysiology diverticula.Methods: A population-based period-prevalence study. Individuals (3.5 million New Zealand residents born 1901–1986) a health system record 1999–2016 were grouped into those hospital diagnosis or diverticulitis (ICD-10-AM K57), and without. Also recorded any diagnoses CTDs. The...
Abstract Bone strength in human cortical bone is determined by the composition and structure of both mineral collagen matrices influenced factors such as age, gender, health, lifestyle genetic factors. Age-related changes matrix are known to result loss mechanical increased fragility. In this study we show how Raman spectroscopy, with its exquisite sensitivity molecular bone, reveals new insights into age- sex-related differences. analysis 18 samples hip obtained from people aged between...
Preptin is a 34-residue pancreatic hormone shown to be anabolic bone in vitro and vivo. The activity of preptin resides within the (1-16) N-terminal fragment. Due its peptidic nature, truncated fragment enzymatically unstable; however it provides an attractive framework for creation stable analogues using various peptidomimetic techniques. An alanine scan was undertaken which showed that substitution Ser at position 3 or Pro 14 did not inhibit proliferative primary rat osteoblasts...