A5055347230- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Barrier Structure and Function Studies
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Optical Systems and Laser Technology
- Pharmacological Effects of Natural Compounds
- Flavonoids in Medical Research
- interferon and immune responses
- Medicinal Plant Pharmacodynamics Research
- Parkinson's Disease Mechanisms and Treatments
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Industrial Vision Systems and Defect Detection
- Ginseng Biological Effects and Applications
- Infrared Target Detection Methodologies
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Microbial Metabolism and Applications
Linyi People's Hospital
2021-2022
Shandong University
2021-2022
Guilin University of Electronic Technology
2021
Chinese Academy of Sciences
2014-2017
Institute of Microbiology
2015-2017
University of Chinese Academy of Sciences
2017
PURPOSE Temozolomide is used in first-line treatment for glioblastoma. However, chemoresistance to temozolomide common glioma patients. In addition, mechanisms the anti-tumor effects of are largely unknown. Ferroptosis a form programmed cell death triggered by disturbed redox homeostasis, overloaded iron, and increased lipid peroxidation. The present study was performed elucidate involvement ferroptosis temozolomide. MATERIALS AND METHODS We utilized CCK8 assay evaluate cytotoxicity. Levels...
Baicalein, a major bioactive flavone constituent isolated from Scutellaria baicalensis Georgi, has neuroprotective properties in several neurological disorders. Many studies suggest that oxidative stress plays central role the pathogenesis of Parkinson's disease (PD). Baicalein also been shown to have antioxidant effects. Therefore, current study was designed investigate whether baicalein could protect against MPP+/MPTP-induced neurotoxicity via suppressing vitro and vivo. In vitro, our...
Ferroptosis is implicated in various tumors, including glioblastoma. Artesunate (ART), an anti-malarial drug, exerted antitumor properties several cancer types. However, the role of ferroptosis inhibiting effect artesunate on glioblastoma remains unclear. The purpose this study was to investigate effects ART and elucidate underlying mechanisms. We found that inhibited proliferation cells vitro tumorigenesis vivo. Characteristic changes were observed group, GSH depletion, lipid peroxidation...
Abstract Background Candidemia is linked with high mortality, highlighting the critical importance of timely empirical antimicrobial therapy and precise medical intervention before a definite etiologic diagnosis. The current study aimed to investigate prevalence pathogens in patients candidemia evaluate potential independent risk factors for Candida albicans bloodstream infections (BSI), as well prognosis candidemia. Methods A retrospective bicentric observational was performed,...
Abstract Background Integrative analysis approaches of metagenomics and metabolomics have been widely developed to understand the association between disease gut microbiome. However, different profiling patterns metabolic samples in make it a matter concern which type sample is most closely associated with microbes disease. To address this lack knowledge, we investigated microbiome metabolomic profiles stool, urine, plasma from ischemic stroke patients healthy subjects. Methods We performed...
Hepatitis B virus (HBV) chronically infects approximately 350 million people worldwide. The replication of HBV which genome is only 3.2 kb long relies heavily on host factors. Previous studies demonstrated that a highly expressed liver-specific microRNA (miRNA) miR-122 suppresses expression and in multiple ways. In this study, we found the response elements viral facilitate highly-expressed hepatocytes. Moreover, mutations are correlated with loads disease progression HBV-infected patients....
The present study aimed to explore the targets and mechanism of Mailuo Shutong Pills(MSP) in treatment ischemic stroke by network pharmacology, verify key through molecular docking animal experiment, so as provide a theoretical basis for clinical application MSP. main chemical ingredients MSP were obtained searching against Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform(TCMSP) relevant literature. potential treating from SwissTargetPrediction DisGeNET....
Abstract Intestinal barrier dysfunction is common in acute ischemic stroke (AIS) and plays a vital role prognosis of AIS. Aberrant expression miRNAs was critical element not only the pathogenesis AIS, but also intestinal function. The present study aims to reveal connection between altered miR-124 further elucidate detailed molecular mechanism. In study, serum markers injury, d-Lactate double amine oxidase (DAO), were detected conduct correlation analysis clinically. Then, medial cerebral...
When the circuit board fails, its operating temperature will be abnormal, which have a greater impact on overall performance of circuit. Therefore, it is very important to identify fault by observing board. This paper introduces identification device for electronic card based binocular imaging and analyzes system design, composition principles upper computer software design results. The uses an infrared camera visible light simultaneously image board, can display thermal with contour TFT LCD...