A5018783079- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Allergic Rhinitis and Sensitization
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Chronic Disease Management Strategies
- Nursing Diagnosis and Documentation
- Ethics in Clinical Research
- Cystic Fibrosis Research Advances
- COVID-19 diagnosis using AI
- Hematological disorders and diagnostics
- Cardiac Structural Anomalies and Repair
- Social Media in Health Education
- Nosocomial Infections in ICU
- Sarcoidosis and Beryllium Toxicity Research
- Infectious Encephalopathies and Encephalitis
- Health and Medical Research Impacts
- Respiratory Support and Mechanisms
- Pericarditis and Cardiac Tamponade
- Bone and Joint Diseases
- Pharmaceutical industry and healthcare
- Advances in Oncology and Radiotherapy
- Neuroinflammation and Neurodegeneration Mechanisms
Hampshire Hospitals NHS Foundation Trust
2021-2024
National Institute for Health Research
2023
Portsmouth Hospitals NHS Trust
2015-2022
University of Portsmouth
2021-2022
Basingstoke and North Hampshire Hospital
2019-2021
National Health Service
2017
Previous reports have shown various cardiac complications to be associated with COVID-19 including: myocardial infarction, microembolic complications, injury, arrythmia, heart failure, coronary vasospasm, non-ischemic cardiomyopathy, stress (Takotsubo) pericarditis and myocarditis. These were respiratory symptoms. However, our case illustrates that myopericarditis tamponade can present without symptoms.A 58-year-old Caucasian British woman was admitted fever, diarrhoea vomiting. She...
Abstract Background Remote monitoring of patient-recorded spirometry and pulse oximetry offers an alternative approach to traditional hospital-based interstitial lung disease (ILD). has been observed reasonably reflect clinic in participants with ILD but remote not widely incorporated into clinical practice. We assessed the feasibility remotely patients within a service. Methods Prospective, single-arm, open-label observational multi-centre study (NCT04850521). Inclusion criteria included...
Background Severe asthma exacerbations are costly to patients and the NHS, occur frequently in severely allergic patients. Objective To ascertain whether or not nocturnal temperature-controlled laminar airflow (TLA) device usage over 12 months can reduce severe improve control quality of life compared with a placebo device, while being cost-effective acceptable adults asthma. Design A pragmatic, multicentre, randomised, double-blind, placebo-controlled, parallel-group, superiority trial...
The LASER Trial is an NIHR-HTA funded, multicentre, randomised controlled trial of allergen intervention, (Temperature-controlled Laminar Airflow,) for patients with severe allergic asthma. To meet our challenging recruitment targets, we have adopted a number different social media based strategies to ensure that the delivers on time. Asthma UK and Allergy advertised their websites shared networks via Facebook Twitter. Asthma alone has 27,000 Twitter followers 35,000 ‘likes.’ This...
Asthma affects more than 5 million patients in the United Kingdom. Nearly 500,000 of these have severe asthma with symptoms and frequent exacerbations that are inadequately controlled available treatments. The burden on NHS is enormous, accounting for 80 % total cost (£1 billion), expensive medications generating much this cost. Of those asthma, 70 sensitised to indoor aeroallergens, level exposure allergens determines symptoms; exposed high levels therefore most at risk hospital admissions....
Chronic obstructive pulmonary disease (COPD) is the second-leading cause of death in United Kingdom and accounts for 1.7% bed days acute hospitals. An estimated two-third patients with COPD remain undiagnosed.Modern Innovative Solutions Improving Outcomes Obstructive Pulmonary Disease (MISSION COPD) aimed to proactively identify from primary care who were undiagnosed or had uncontrolled provide a comprehensive integrated multidisciplinary clinic address needs this complex group improving...
Background: There are an estimated three million people in the United Kingdom with chronic obstructive pulmonary disease (COPD), and incidence of bronchiectasis is at around 0.1% but more common COPD severe asthma. Both characterized by exacerbations which bacteria play a central role. Pseudomonas aeruginosa isolated from sputum samples 4% to 15% adults likely be patients disease. Earlier detection may improve morbidity mortality expediting treatment. Aseptika Ltd has developed system for...
The LASER Trial is an RCT of the effectiveness use a Temperature-controlled Laminar Airflow (TLA) device in adults with severe allergic asthma. trial funded by NIHR-HTA. The aims to determine whether home-based nocturnal treatment TLA can reduce frequency asthma exacerbations over one year period. In order inform decisions about implementation should it be shown effective, participant's experience using being assessed means qualitative interviews. We conducted telephone interviews 10...
Background: Allergen avoidance is important in allergic asthma management. Nocturnal treatment with Temperature-controlled Laminar Airflow (TLA) has been shown to provide a significant reduction the exposure allergens breathing zone, leading long-term airway inflammation and improvement Quality of life (QoL). Allergic patients symptomatic on Global Initiative for Asthma (GINA) step 4/5 were found benefit most as measured by Life Questionnaire (AQLQ). However, effect TLA severe exacerbations...
Background: Chronic obstructive pulmonary disorder (COPD) affects over 1 million people in the United Kingdom, and person dies from COPD every 20 minutes. The cost to with National Health Service is huge – more than 24 working days lost a year annual expenditure on £810 £930 year.
<h3>Introduction</h3> Remote monitoring of patient-recorded spirometry & pulse oximetry offers an alternative approach to traditional hospital-based interstitial lung disease (ILD), which may support resource optimisation and patient safety. Whilst studies have shown agreement between remote hospital based spirometry, has not been widely incorporated into clinical practice. We aimed assess the feasibility introduction service. <h3>Methods</h3> Prospective, single-arm, observational study...
<b>Background:</b> Recruitment to clinical trials is often slower and more challenging than expected with failing recruit their target sample size within agreed timelines. <b>Aims objectives:</b> Portsmouth Hospitals NHS Trust (PHT) Respiratory Research Team have built a database of patients respiratory diseases who consented being contacted discuss participation in research trials. We wanted see whether Educational Information Events would help encourage research. <b>Methods:</b> The was...
<b>Introduction:</b> The MISSION COPD project delivered a one-stop carousel model of integrated care to patients in Wessex Autumn 2015. <b>Methods:</b> Patients were identified using the GRASP tool. subdivided "case cohort" where no diagnosis was documented but suspected, and "care there pre-existing diagnosis. Data on healthcare usage for 12 months before clinic 6 after (annualised months) used assess efficacy model. <b>Results:</b> 108 reviewed, with 98 being included research project....
<sec> <title>BACKGROUND</title> Chronic obstructive pulmonary disease (COPD) is the second-leading cause of death in United Kingdom and accounts for 1.7% bed days acute hospitals. An estimated two-third patients with COPD remain undiagnosed. </sec> <title>OBJECTIVE</title> Modern Innovative Solutions Improving Outcomes Obstructive Pulmonary Disease (MISSION COPD) aimed to proactively identify from primary care who were undiagnosed or had uncontrolled provide a comprehensive integrated...
<b>Background:</b> Sarcoidosis is a systemic granulomatous disease. Clinical course varies amongst those affected. It remains difficult to predict which patients will develop chronic progressive <b>Objective:</b> Evaluate how managed our cohort of in District General Hospital (DGH) and identify any phenotypes might outcome. <b>Method:</b> We performed retrospective analysis Patients. reviewed clinic letters, radiology PFTs over 8 years at Basingstoke North Hampshire DGH. compared data the...
Abstract Purpose Uncontrolled severe asthma constitutes a major economic burden to society. Add-ons standard inhaled treatments include inexpensive oral corticosteroids and expensive biologics. Nocturnal treatment with Temperature-controlled Laminar Airflow (TLA; Airsonett®) could be an effective, safe cheaper alternative. The potential of TLA in reducing exacerbations was addressed recent randomised placebo-controlled trial (RCT) patients (Global Initiative for Asthma (GINA) step 4/5), but...
<h3>Introduction</h3> Remote monitoring of pulse oximetry and spirometry has been proposed as an alternative to hospital based measurements for patients with interstitial lung disease (ILD). We aimed understand factors impacting the acceptability remote patients. <h3>Methods</h3> Secondary analysis study NCT04850521: Patients ILD were asked record daily 91 days. Adherence was defined percentage days a recording. Health related quality life (HRQoL) measured using EQ-5D-5L. Patient experience...
<h3>Objectives</h3> In December 2019, an outbreak of coronavirus (COVID-19) started in Wuhan, China, and quickly spread across the world. We describe features seen on chest radiograph (CXR) at disease onset, natural history these changes after approximate two-month follow-up period, further respiratory investigations requested following discussion with patients who recovered from illness. <h3>Materials Methods</h3> From March 16, 2020, to June 4, CXR 86 (23–87 years, 50 males) were admitted...