A5040772969- Gut microbiota and health
- Folate and B Vitamins Research
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Vibrio bacteria research studies
- Salmonella and Campylobacter epidemiology
- Listeria monocytogenes in Food Safety
- Inflammatory Bowel Disease
- Microbial Metabolites in Food Biotechnology
ETH Zurich
2022-2024
McGill University
2019
To produce the health-associated metabolite propionate, gut microbes require vitamin B12 as a cofactor to convert succinate propionate. is sourced in human from unabsorbed dietary fraction and situ microbial production. However, experimental data for production by scarce, especially on their produced B12-analogues. Further, promotion of propionate microbially-produced not yet fully understood. Here, we demonstrated 6 out 8 silico predicted B12-producing bacteria gut. Next, showed vitro that...
Vitamin B12 (cobalamin) is present in the human lower gastrointestinal tract either coming from unabsorbed dietary fraction or situ production of gut microbiota. However, it unclear whether microbial communities need exogenous for growth and metabolism, low high levels could affect community composition metabolite production. Here, we investigated vitro fecal microbiota effects different (as cyanocobalamin) on activity. Eight healthy adults distributed over three enterotypes, dominated by...
Abstract In patients with inflammatory bowel diseases (IBD), dietary micronutrient intake is low and deficiencies are common. Besides the host, also gut microbiota require micronutrients levels may disturb its functioning. Multi‐omics studies indeed detected shifts in micronutrient‐dependent microbial pathways IBD. It however not clear whether alleviate inflammation directly, by modulating immune system, or indirectly, structure function of microbiota. The latter seems particular interest,...
Whole genome sequencing (WGS) is rapidly replacing other molecular techniques for identifying and subtyping bacterial isolates. The resolution or discrimination offered by WGS significantly higher than that techniques, readily allows infrequent differences occur between 2 closely related strains to be found. In this investigation, was used identify the changes occurred in genomes of 13 foodborne pathogens after 100 serial subcultures. Pure cultures Shiga-toxin-producing Escherichia coli,...