A5008249371- Pneumonia and Respiratory Infections
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Inhalation and Respiratory Drug Delivery
- Respiratory viral infections research
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Viral Infections and Immunology Research
- Neonatal Respiratory Health Research
- Liver Disease Diagnosis and Treatment
- Influenza Virus Research Studies
Yangzhou University
2025
Ministry of Agriculture and Rural Affairs
2025
Tsinghua University
2021-2024
Many encapsulated bacteria use capsules to cause invasive diseases. However, it remains largely unknown how the enhance bacterial virulence under in vivo infection conditions. Here we show that primarily target liver survival at onset of blood-borne infections. In a mouse sepsis model, enabled human pathogens Streptococcus pneumoniae and Escherichia coli circumvent recognition liver-resident macrophage Kupffer cells (KCs) capsular serotype-dependent manner. contrast effective capture...
ABSTRACT Plasma C-reactive protein (CRP) is widely used as a biomarker for bacterial infections due to its massive induction during infections, however, the precise function of CRP in remains undefined. Here we show that enables Kupffer cells (liver macrophages) capture and eliminate wide range encapsulated bacteria from bloodstream mice thereby provides rapid effective immunity. Mechanistically, binds structurally diverse capsular polysaccharides major Gram-positive -negative pathogens,...
Streptococcus pneumoniae resides in the human upper airway as a commensal but also causes pneumonia, bacteremia, meningitis, and otitis media. It remains unclear how pneumococci adapt to nutritional conditions of various host niches. We here show that MetR, LysR family transcriptional regulator, serves molecular adaptor for pneumococcal fitness, particularly airway. The metR mutant strain D39 rapidly disappeared from nasopharynx was marginally attenuated lungs bloodstream mice. RNA-seq...
ABSTRACT Certain serotypes of encapsulated bacteria are more associated with severe pneumonia than others, but the biological reason behind this association has remained largely unknown. This study uncovered a causal relationship between capsule serotype and virulence phenotype Streptococcus pneumoniae , leading cause community-acquired pneumonia, in mice using isogenic bacteria. high-virulence (HV) persist lungs lead to whereas low-virulence (LV) effectively cleared. The type-dependent...