A5025857523- Evolution and Genetic Dynamics
- Plant and animal studies
- Ecology and Vegetation Dynamics Studies
- Cystic Fibrosis Research Advances
- Mathematical and Theoretical Epidemiology and Ecology Models
- Animal Behavior and Reproduction
- Evolutionary Game Theory and Cooperation
- Animal Ecology and Behavior Studies
- Cancer Genomics and Diagnostics
- Insect and Arachnid Ecology and Behavior
- Respiratory viral infections research
- Cancer Cells and Metastasis
- Mathematical Biology Tumor Growth
- Influenza Virus Research Studies
- Advanced Breast Cancer Therapies
- Transplantation: Methods and Outcomes
- Species Distribution and Climate Change
- COVID-19 epidemiological studies
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Genetic diversity and population structure
- Viral Infections and Outbreaks Research
- Land Use and Ecosystem Services
University of Utah
2016-2025
Huntsman Cancer Institute
2023-2024
University of California, Davis
1992-2021
Decision Sciences (United States)
2021
St. Lawrence University
2021
Drexel University
2021
Ecological Society of America
2019
John Wiley & Sons (United States)
2019
Ecosystem Sciences
2019
VA Salt Lake City Healthcare System
2015
Hydraulic conductivity ( K ) in the soil and xylem declines as water potential Ψ declines. This results a maximum rate of steady‐state transpiration E crit corresponding minimum leaf at which has approached zero somewhere soil–leaf continuum. Exceeding these limits causes transport to cease. A model determined whether point hydraulic failure (where = 0) occurred rhizosphere or components Below threshold root:leaf area R : L ), loss limited . Above threshold, from cavitation was limiting. The...
The objective of this study was to create a 5-year survivorship model identify key clinical features cystic fibrosis. Such could help researchers and clinicians evaluate therapies, improve the design prospective studies, monitor practice patterns, counsel individual patients, determine best candidates for lung transplantation. authors used information from Cystic Fibrosis Foundation Patient Registry (CFFPR), which has collected longitudinal data on approximately 90% fibrosis patients...
Abstract A large array of species distribution model ( SDM ) approaches has been developed for explaining and predicting the occurrences individual or assemblages. Given wealth existing models, it is unclear which models perform best interpolation extrapolation data sets, particularly when one concerned with We compared predictive performance 33 variants 15 widely applied recently emerged s in context multispecies data, including both joint that multiple together, stacked each individually...
Background. This study: (1) describes the viral etiology of respiratory illness by prospectively collecting weekly symptom diaries and nasal swabs from families for 1 year, (2) analyzed data reported symptoms, virus, age, family composition, (3) evaluated duration virus detection. Methods. Twenty-six households (108 individuals) provided concurrent swab 4166 person-weeks. The FilmArray polymerase chain reaction (PCR) platform (BioFire Diagnostics, LLC) was used to detect 16 viruses. Viral...
A large recombinant inbred population of soybean has been characterized for 220 restriction fragment-length polymorphism (RFLP) markers. Values agronomic traits also have measured. Quantitative trait loci (QTL) height, yield, and maturity were located by their linkage to RFLP QTL controlling amounts variation analyzed the dependence on particular alleles at a second locus comparing cumulative distributions each genotype (four genotypes per pair loci). Interesting pairs statistically with...
Secondary bacterial infections are a leading cause of illness and death during epidemic pandemic influenza. Experimental studies suggest lethal synergism between influenza certain bacteria, particularly Streptococcus pneumoniae, but the precise processes involved unclear. To address mechanisms determine influences pathogen dose strain on disease, we infected groups mice with either H1N1 subtype A virus A/Puerto Rico/8/34 (PR8) or version expressing 1918 PB1-F2 protein (PR8-PB1-F2(1918)),...
The effects of lung transplantation on the survival and quality life in children with cystic fibrosis are uncertain.
We use a common framework to compare three models of plant strategies confront herbivory: constitutive defense, optimal inducible and the "moving target." Plants with defenses retain fixed defensive phenotype. respond attack by increasing defenses. following moving target strategy altering The defense models, unlike model, require that phenotypes can be arrayed along an axis representing trade-off between cost defense. argue evidence for such is not yet convincing. Our indicate are favored...
Eudicot angiosperms with greater vulnerability to xylem cavitation tend have vessels total area of inter-vessel pits, which inspired the 'rare pit' hypothesis: more pits per vessel, by chance leakier will be vessel's single air-seeding pit and lower threshold for spread between vessels. Here, we demonstrate feasibility hypothesis, using probability theory model axial propagation air through air-injected stems. In presence rare, leaky pressures short stems few vessel ends in series should...
The decay of mRNA plays a vital role in modulating abundance, which, turn, influences cellular and organismal processes. In plants metazoans, three distinct pathways carry out the most cytoplasmic mRNAs: decapping complex, which requires scaffold protein VARICOSE (VCS), removes protective 5′ cap, allowing for to 3′ via EXORIBONUCLEASE4 (XRN4, XRN1 metazoans yeast), both exosome SUPPRESSOR OF VCS (SOV)/DIS3L2 degrade RNAs direction. However, unique biological contributions these pathways,...
Significance The evolution of peripheral immune cell abundance and signaling over time, as well how these cells interact with the tumor, may impact a cancer patient’s response to therapy. By developing an ecological population model, we provide evidence dynamic predator–prey-like relationship between circulating tumor size in patients that respond immunotherapy. This is not found either are nonresponsive immunotherapy or during chemotherapy. Single-cell RNA sequencing serial blood samples...
Evolution of mammalian skeletal structure can be rapid and the changes profound, as illustrated by morphological diversity domestic dog. Here we use principal component analysis variation in a population Portuguese Water Dogs to reveal systems traits defining structures. This classifies phenotypic into independent components that used dissect genetic networks regulating complex biological systems. We show unlinked quantitative trait loci associated with these individually promote both...
This paper presents a simulation and three approximations designed to study the effects of spatial clumping patches in metapopulation linked by costly dispersal. Assuming that all are identical each experiences simple regime density-independent uncorrelated extinction, we demonstrate enhances persistence population. We find threshold which depends on leading eigenvalue matrix describing dispersal success between pair show this exceeds mean success. An averaged approximation uses single...
Defensive morphologies, chemicals and behaviors induced by cues from consumers or competitors have been described in numerous organisms. Much work has focused on the costs of defenses actual used. Here, we review recent progress determining effects inducible implicated inducing against competitors, thereby laying groundwork for studying implications dynamics foraging, population size evolution.
Lung transplantation in cystic fibrosis may improve survival for patients with low 5-year predicted survival. Identifying characteristics that affect post-transplantation patient selection and benefit. Using Cystic Fibrosis Foundation Patient Registry United Network Organ Sharing data, we identified 845 lung transplant recipients from 1991-2001, 12,826 control 1997. We used Cox proportional hazards models to identify variables influence To estimate the benefit of affected by variables,...
Section:ChooseTop of pageAbstract <<Lung Transplantation for ...Pediatric Lung Transplant...Operative and Perioperati...(Non)-Adherence in Cystic...The Importance Measuri...Three Sociohistorical Cha...Alternate Models Selec...Some Comments on Study De...Lung ...ReferencesCITING ARTICLES
Significance Pathogens that invoke an immune response immediately after infection can also provide partial cross-protection against other strains of the same or closely related pathogens. This shape epidemiological dynamics multistrain pathogens when epidemic one strain temporarily suppresses transmission another. Identifying these interactions from time series data is difficult, particularly prevalence oscillates seasonally. We use long-term incidence on Respiratory Syncytial Virus (RSV),...