A5057490939- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Transplantation: Methods and Outcomes
- Cancer Immunotherapy and Biomarkers
- Renal and Vascular Pathologies
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Mechanical Circulatory Support Devices
- Vitamin C and Antioxidants Research
- Cancer-related gene regulation
- Oral health in cancer treatment
- Head and Neck Cancer Studies
- Vitamin D Research Studies
- Psoriasis: Treatment and Pathogenesis
- Cancer Genomics and Diagnostics
- Vasculitis and related conditions
- Bacterial Identification and Susceptibility Testing
- Polyomavirus and related diseases
- Pregnancy and Medication Impact
- Single-cell and spatial transcriptomics
- Immune responses and vaccinations
- Intensive Care Unit Cognitive Disorders
University of California, Los Angeles
2016-2025
The University of Texas MD Anderson Cancer Center
2024
The University of Texas Health Science Center at Houston
2023-2024
Immungenetics (Germany)
2019
UCLA Health
2017-2018
Significance The evolution of peripheral immune cell abundance and signaling over time, as well how these cells interact with the tumor, may impact a cancer patient’s response to therapy. By developing an ecological population model, we provide evidence dynamic predator–prey-like relationship between circulating tumor size in patients that respond immunotherapy. This is not found either are nonresponsive immunotherapy or during chemotherapy. Single-cell RNA sequencing serial blood samples...
Abstract Background Staphylococcus aureus bacteremia (SAB) is a prevalent life-threatening infection often caused by methicillin-resistant S. (MRSA). Up to 30% of SAB patients fail clear even with gold-standard anti-MRSA antibiotics. This phenomenon termed antibiotic-persistent MRSA (APMB). The mechanisms driving APMB are complex and involve host phenotypes significantly impacting the immune response. Thus, defining early signatures clinical that differentiate from antibiotic resolving...
Objectives/Goals: Clinical relevance of preclinical animal models is commonly in question. Herein, we investigated locoregional tumor immune microenvironment (TIME) differences tumor-bearing murine oral cancer models, unresponsive to traditional immunotherapy, and also developed an resection model ultimately enhance translational relevance. Methods/Study Population: Here, utilized carcinogen-induced, HPV-negative models. For TIME studies, ROC1 cells were maintained as published. tumors...
Within the innate immune system, effector lymphocytes known as natural killer (NK) cells play an essential role in host defense against aberrant cells, specifically eliminating tumoral and virally infected cells. Approximately 30 monogenic defects, together with a of other pathological conditions, cause either functional or classic NK cell deficiency, manifesting reduced absent cytotoxic activity. Historically, cytotoxicity has been investigated radioactive methods, which are cumbersome,...
CMV causes mostly asymptomatic but lifelong infection. Primary infection or reactivation in immunocompromised individuals can be life-threatening. viremia often occurs solid organ transplant recipients and associates with decreased graft survival higher mortality. Furthering understanding of impaired immunity that allows is critical to guiding antiviral therapy examining the effect on outcomes. This study characterized longitudinal immune responses 31 kidney matched, nonviremic recipients....
Within the innate immune system, effector lymphocytes known as natural killer (NK) cells play an essential role in host defense against aberrant cells, specifically eliminating tumoral and virally infected cells. Approximately 30 monogenic defects, together with a of other pathological conditions, cause either functional or classic NK cell deficiency, manifesting reduced absent cytotoxic activity. Historically, cytotoxicity has been investigated radioactive methods, which are cumbersome,...
Background The number of elderly patients with end-stage kidney disease requiring transplantation continues to grow. Evaluation healthy older adults has revealed proinflammatory changes in the immune system, which are posited contribute age-associated illnesses via “inflamm-aging.” Immunologic dysfunction is also associated impaired control infections. Whether these immunologic found transplant recipients not currently known, but may have important implications for risk adverse clinical...
Belatacept has shown potential for prevention of rejection after kidney transplantation, given its demonstration reduced nephrotoxicity in combination with absence significant incidence rejection. However, concerns have been raised regarding increased risk viral infection.We set out to explore the impact switch belatacept on alloimmune and antiviral immunity through study patients switched from calcineurin inhibitor (CNI) within 3 months transplantation compared a matched cohort control...
<h3>Background</h3> Tumor-bearing murine models are frequently used in head and neck cancer research. Subcutaneous heterotopic tumors often utilized for their simplicity of implantation ease tumor access. However, orthotopic models, implanted into relevant organ-specific environments, widely considered more translationally relevant. While both may be to study squamous cell carcinomas (HNSCC), few studies have directly compared the immune microenvironments (TIME) tumors. Moreover, draining...
<h3>Background</h3> Head and Neck Squamous Cell Carcinoma (HNSCC), the sixth most common cancer worldwide, is associated with high-risk subtypes of human papillomavirus (HPV), tobacco, alcohol over-consumption. Standard care treatments include surgery, radiation or chemoradiation. Five-year survival rates for patients locoregionally advanced HNSCC have not significantly improved in decades remain at approximately 60%, driving need novel treatment strategies such as immunotherapy....
Leptin is derived in adipose tissue and circulates the body to play a key role metabolism energy regulation. In non-psychiatric populations, there evidence that leptin levels are associated with neurocognitive performance. The production of its circulating soluble binding receptor increases during exercise, which has been neuroplasticity memory enhancement. (SLR) main protein blood humans, serves as an antagonist transport brain. Cognitive deficits well established schizophrenia, even early...
Upon presentation of clinical symptoms, renal transplant recipients routinely undergo needle core biopsy to diagnose acute graft rejection. This procedure is invasive and associated with patient morbidity. We aimed at validating a panel plasma proteins as minimally cost-effective set biomarkers rule out allograft Based on mass-spectrometry-based pilot study, 8 were selected be tested by ELISA in 164 adult recipients, including 91 non-rejectors 73 rejectors. The rejectors sampled the time...
Compared with younger patients on similar immunosuppression regimens, older solid-organ transplant recipients experience increased rates of infection and death, but decreased rejection. The mechanism behind these differences has yet to be defined, may related ÒinflammagingÓ driven by CMV infection. objective this study was evaluate vs. for CMV-specific T-cell immune responses. Peripheral blood mononuclear cells were isolated from 20 (3 age 60) 25 matched (ages 30–59) kidney at 3 months after...
Abstract The extent that immune cell phenotypes in the peripheral blood reflect within-tumor activity prior to and early cancer therapy is unclear. To address this question, we studied population dynamics of tumor cells, phenotypic changes, using clinical measurements single genomic analyses. These samples were serially obtained from a cohort advanced gastrointestinal patients enrolled on trial with chemotherapy immunotherapy. Using an ecological model, fitted burden abundance data each...