A5047322826- COVID-19 epidemiological studies
- Signaling Pathways in Disease
- ATP Synthase and ATPases Research
- Gene Regulatory Network Analysis
- Force Microscopy Techniques and Applications
- Ion channel regulation and function
- Microbial Metabolic Engineering and Bioproduction
- Infection Control and Ventilation
- COVID-19 Clinical Research Studies
- Neuroscience and Neuropharmacology Research
- Data-Driven Disease Surveillance
- Influenza Virus Research Studies
- RNA Interference and Gene Delivery
- Bioinformatics and Genomic Networks
- COVID-19 diagnosis using AI
- COVID-19 and healthcare impacts
University of Freiburg
2021-2023
Czech Academy of Sciences, Institute of Physics
2023
Reproducibility and reusability of the results data-based modeling studies are essential. Yet, there has been—so far—no broadly supported format for specification parameter estimation problems in systems biology. Here, we introduce PEtab, a which facilitates using Systems Biology Markup Language (SBML) models set tab-separated value files describing observation model experimental data as well parameters to be estimated. We already implemented PEtab support into eight well-established...
Abstract Background The COVID-19 pandemic has led to a high interest in mathematical models describing and predicting the diverse aspects implications of virus outbreak. Model results represent an important part information base for decision process on different administrative levels. Robert-Koch-Institute (RKI) initiated project whose main goal is predict COVID-19-specific occupation beds intensive care units: Steuerungs-Prognose von Intensivmedizinischen Kapazitäten (SPoCK). incidence...
Calcineurin B homologous protein 3 (CHP3) is an EF-hand Ca2+-binding involved in regulation of cancerogenesis, cardiac hypertrophy, and neuronal development through interactions with sodium/proton exchangers (NHEs) signalling proteins. While the importance Ca2+ binding myristoylation for CHP3 function has been recognized, underlying molecular mechanism remained elusive. In this study, we demonstrate that independently affect conformation functions human CHP3. increased local flexibility...
Abstract Background The COVID-19 pandemic has led to a high interest in mathematical models describing and predicting the diverse aspects implications of virus outbreak. Model results represent an important part information base for decision process on different administrative levels. Robert-Koch-Institute (RKI) initiated project whose main goal is predict COVID-19-specific occupation beds intensive care units: Steuerungs-Prognose von Intensivmedizinischen Kapazitäten (SPoCK). incidence...
Zusammenfassung Hintergrund Zeitdynamische Prognosemodelle spielen eine zentrale Rolle zur Steuerung von intensivmedizinischen COVID-19-Kapazitäten im Pandemiegeschehen. Ein wichtiger Vorhersagewert (Prädiktor) für die zukünftige intensivmedizinische (ITS-)COVID-19-Bettenbelegungen ist Anzahl der SARS-CoV-2-Neuinfektionen in Bevölkerung, wiederum stark Schwankungen Wochenverlauf, Meldeverzug, regionalen Unterschieden, Dunkelziffer, zeitabhängiger Ansteckungsrate, Impfungen,...
Abstract Calcineurin B homologous protein 3 (CHP3) is an EF-hand Ca 2+ -binding involved in regulation of cancerogenesis, cardiac hypertrophy and neuronal development via interactions with sodium/proton exchangers (NHEs) signalling proteins. CHP3 binds micromolar affinity providing the basis to respond intracellular signals. binding myristoylation are important for function but underlying molecular mechanism remained elusive. Here, we show that independently affect conformational dynamics...