Rachel Bowen-James
A5041497910- Genomics and Phylogenetic Studies
- Cancer Immunotherapy and Biomarkers
- Bacteriophages and microbial interactions
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
UNSW Sydney
2020-2022
Garvan Institute of Medical Research
2021
Abstract Background Molecular profiling of the tumour immune microenvironment (TIME) has enabled rational choice immunotherapies in some adult cancers. In contrast, TIME paediatric cancers is relatively unexplored. We speculated that a more refined appreciation childhood cancers, rather than reliance on commonly used biomarkers such as mutation burden (TMB), neoantigen load and PD-L1 expression, an essential prerequisite for improved solid Methods combined immunohistochemistry (IHC) with RNA...
InterARTIC is an interactive web application for the analysis of viral whole-genome sequencing (WGS) data generated on Oxford Nanopore Technologies (ONT) devices. A graphical interface enables users with no bioinformatics expertise to analyze WGS experiments and reconstruct consensus genome sequences from individual isolates viruses, such as SARS-CoV-2. intended facilitate widespread adoption standardization ONT surveillance molecular epidemiology.We demonstrate use SARS-CoV-2 Ebola virus,...
ABSTRACT Motivation InterARTIC is an interactive web application for the analysis of viral whole-genome sequencing (WGS) data generated on Oxford Nanopore Technologies (ONT) devices. A graphical interface enables users with no bioinformatics expertise to analyse WGS experiments and reconstruct consensus genome sequences from individual isolates viruses, such as SARS-CoV-2. intended facilitate widespread adoption standardisation ONT surveillance molecular epidemiology. Worked example We...
Abstract Molecular profiling of the tumour immune microenvironment (TIME) has enabled rational choice immunotherapies in some adult cancers. In contrast, TIME paediatric cancers is relatively unexplored. We speculated that a more refined appreciation childhood cancers, rather than reliance on commonly used biomarkers such as mutation burden (TMB), neoantigen load and PD-L1 expression, an essential prerequisite for improved solid combined immunohistochemistry (IHC) molecular to develop...