A5067172154- Chemotherapy-induced organ toxicity mitigation
- Drug-Induced Hepatotoxicity and Protection
- Meat and Animal Product Quality
- Nigella sativa pharmacological applications
- Animal Nutrition and Physiology
- Nerve injury and regeneration
- Bee Products Chemical Analysis
- Effects of Environmental Stressors on Livestock
- Parasitic Infections and Diagnostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- Insect and Pesticide Research
- Sperm and Testicular Function
- Sesame and Sesamin Research
- Reproductive Biology and Fertility
- Essential Oils and Antimicrobial Activity
- Neurological Disease Mechanisms and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Infant Nutrition and Health
- Bioactive Compounds in Plants
- Ovarian cancer diagnosis and treatment
- Microbial Inactivation Methods
- Selenium in Biological Systems
- Milk Quality and Mastitis in Dairy Cows
- Heparin-Induced Thrombocytopenia and Thrombosis
Mustafa Kemal University
2017-2024
The aim of this study is to evaluate the effect apigenin on inflammatory response in brain tissue Parkinson's mouse model.
Gentamicin, an aminoglycoside antibiotic, is nowadays widely used in the treatment of gram-negative microorganisms. The antimicrobial, anti-inflammatory, and antioxidant activities eucalyptol, a type saturated monoterpene, have been reported many studies. aim this study was to examine possible effects eucalyptol on gentamicin-induced renal toxicity. A total 32 rats were divided into 4 groups; Control (C), Eucalyptol (EUC), Gentamicin (GEN), + (GEN EUC). In order induce toxicity, 100 mg/kg...
This study was aimed to explore the therapeutic effect of eucalyptol on cisplatin induced kidney damage in Wistar albino rats. The animals were divided into four groups: sham (S), (E), (C), and + (CE) randomly, six each group. Groups C CE received (12 mg/kg, a single dose, intraperitoneally (i.p.)). E treated with (100 for seven days, orally). blood samples tissues collected following sacrification analyzed histopathologically biochemically. Histopathological results revealed tubular...
We investigated the possible ameliorative effects of nobiletin (NBL) against methotrexate (MTX)-induced hepatorenal toxicity in rats. Twenty-eight Wistar albino rats were randomly divided into four groups, namely: Control; MTX (administered 20 mg/kg MTX); MTX+NBL and 10 NBL per day); mg/kg/day NBL). Histopathological, immunohistochemical biochemical analyses performed on kidney liver tissues at end study. caused renal toxicity, as indicated by increases malondialdehyde (MDA) caspase-3, well...
This study was designed to investigate the possible antioxidant, antiapoptotic and neuroprotective effects of nobiletin on cisplatin-induced neurotoxicity rat model by evaluating neurotrophins, antioxidants histopathology.
Possible protective and therapeutic effects of nobiletin on kidney in a cisplatin-induced nephrotoxicity rat model were investigated. Forty male albino rats divided into four groups: control, cisplatin (CIS), cisplatin+nobiletin (CIS+NOB), nobiletin+cisplatin (NOB+CIS). At the end study, subjected to biochemical, histological immunohistochemical analyzes. Compared control group, tGSH (p < 0.05) levels, G6PD GPx 0.001) activities, increased CIS group; while significant decreases occurred MDA...
In metabolic syndrome, activated inflammatory signaling pathways trigger the release of proinflammatory cytokines. Nowadays, use natural bioactive compounds is trending as an alternative method for treatment and management syndrome. This study aimed to assess potential effects hesperidin in syndrome model by analyzing anti-inflammatory cytokines serum liver. Rats were divided into 4 groups: Control (Rats fed a standard chow diet water ad libitum), [Rats supplemented (1%, 10 g/kg feed)...
This research aimed to evaluate the effect of different doses black cumin (Nigella sativa L.) seed (BCS) on growth performance, blood parameters, liver oxidant/anti-oxidant levels and fatty syndrome in quails. Four hundred thirty-two unsexed (male female) three-day-old Japanese quail (Coturnix coturnix japonica) chicks were divided into four treatment groups (108 per group) with six replicates (18 replicate). Control experimental fed for 35 days basal feed including 0.00, 0.50, 1.00 2.00%...
Abstract Objective The aim of this study was to evaluate the protective effects cornelian cherry fruit extract against cisplatin-induced nephrotoxicity in vitro. Materials and methods African green monkey kidney epithelial cells (Vero) were incubated with 100 mg/mL extract, 50 μmol/L cisplatin or plus for 4 h. wells containing without any supplementation served as control. Cell viability determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazoliumbromide assay. Culture mediums...
ÖZETNörotrofinler, nöronların sağkalımını ve fonksiyonlarını etkileyen, sinaptik fonksiyonu plastisiteyi kontrol eden polipeptid yapılı büyüme faktör ailesidir.Nörotrofin ailesi üyeleri, sinir faktörü, beyin kaynaklı nörotrofik faktör, nörotrofin-3, nörotrofin-4/5, nörotrofin-6, nörotrofin-7'dir.Nörotrofinler, merkezi sistemi, periferal sistemi nöronları dokulardaki birçok hücre tipinden sentezlenmektedir hem sisteminde de dışındaki pek çok dokuda biyolojik etkiye sahip oldukları...
Epidermal buyume faktoru, hucrelerin bolunmesi, farklilasmasi, yasamasi, cogalmasi, buyumesi ve hucre gocunu uyaran protein yapida bir faktoru olup, organizmadaki pek cok fizyolojik patolojik surecte rol almaktadir. EGF, anti-enflamatuar, anti-apoptotik, norotrofik noroprotektif etkilere sahiptir. reseptorleri akciger, mide, duodenum, pankreas, bobrek, hipofiz bezi, tiroid meme yumurtalik, uterus, plasenta, kornea gliya hucrelerinde bulunmaktadir. Trombositler, makrofajlar, monositler...
One of the problems dairy industry which causes major economic losses due to reduced milk yield and quality, is "Mastitis". Mastitis a disease that occurs in glandular tissue mammary gland caused by infectious agents. Since derived products are consumed large part World’s population, quality becames important. Rapid, non-destructive analysis Raman Spectroscopy great advantage. In study, it aimed investigate molecular structures normal mastitic milks using spectroscopy this study first done...
The current study aimed to investigate the effects of electrical stimulation on brain-derived neurotrophic factor (BDNF) and nerve growth (NGF) levels in rats with sciatic injury. Twenty-eight were divided into four groups sham (S, n=7), (ES, injury (SNI, n=7) injury+electrical (SNI+ES, n=7). An experimental damage model was produced by applying a closing force compress nerve. Electrical applied for twenty minutes at 200 μs, 2mA, 20 Hz fifteen days. Enzyme-linked immunosorbent assay analysis...
Gentamicin (GM), which is in the aminoglycoside antibiotic class, frequently preferred today treatment of diseases caused by gram-negative bacteria. However, its significant side effects on liver and kidney functions limit clinical usefulness. The antioxidant anti-inflammatory medical activities eucalyptol (EUC, 1.8-cineole) have been reported different studies. This study aimed to evaluate EUC GM-induced hepatotoxicity. groups are consisted control (C), EUC, GM + there were 7 rats each...
Glucose-6-phosphate dehydrogenase (G6PD) is the first enzyme of pentose phosphate metabolic pathway that supplies reducing agents by maintaining level reduced nicotinamide adenine dinucleotide phosphate.It was aimed to determine activity erythrocyte and spermatozoa G6PD in breeding non-breeding seasons Merino rams. And also, find out relation these parameters with sperm quality for better understanding role this male fertility.1.5-2 yr-old healthy, 14 rams were involved. Ejaculate samples...
The use of
 flavonoids promises new approach for the treatment of neurodegenerative
 diseases. Nobiletine is a polymethoxy flavonoid found in citrus peel. The
 neuroprotective effect nobiletin has been demonstrated vivo and vitro.
 affects signaling cascades associated with learning memory,
 alleviates neurodegeneration by modulating inflammatory mediators, inhibits
 motor cognitive dysfunction increasing dopamine release enhances
 memory recognition...