A5005641582- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- COVID-19 and healthcare impacts
- Airway Management and Intubation Techniques
- Infectious Aortic and Vascular Conditions
- Vascular Procedures and Complications
- Connective tissue disorders research
- Global Health and Epidemiology
- Environmental and Sediment Control
- Tracheal and airway disorders
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Voice and Speech Disorders
- Acute Ischemic Stroke Management
- Molecular Biology Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Folate and B Vitamins Research
- Streptococcal Infections and Treatments
- Organ Transplantation Techniques and Outcomes
- Clinical practice guidelines implementation
- Vascular anomalies and interventions
NIHR Bristol Cardiovascular Biomedical Research Unit
2017-2024
University of Bristol
2019-2024
University Hospitals Bristol NHS Foundation Trust
2022-2024
Bristol Royal Infirmary
2021-2024
University Hospitals Bristol and Weston NHS Foundation Trust
2024
Emory University
2020-2021
Saint Joseph's Hospital
2021
Universität Hamburg
2020
University Medical Center Hamburg-Eppendorf
2020
Emory and Henry College
2020
The global
No reliable scores are available to predict mortality following surgery for type A acute aortic dissection (TAAAD). Recently, the German Registry of Acute Aortic Dissection Type (GERAADA) score has been developed. We aim compare how GERAADA performs in predicting operative TAAAD European System Cardiac Operative Risk Evaluation (EuroSCORE) II.
Aim: Reconstructive surgery is a life-saving treatment for individuals with advanced thoracic aortic aneurysms (TAAs) at risk of rupture. No effective pharmacological treatments are available to halt dilatation before it reaches this critical point. Unravelling the cellular and molecular pathways involved in TAA formation expansion fundamental identifying potential targets. This study challenged hypothesis that pericyte dysfunction destabilizes adventitial vascular niche, hence compromising...
Abstract Background Surgical pulmonary embolectomy is rarely used for the treatment of massive acute embolism. The aim this study was to assess incidence and outcomes operation by undertaking a retrospective analysis large national registry in UK. Methods All embolectomies performed between 1996 2018 were captured National Institute Cardiovascular Outcomes Research central database. Trends number operations during interval reported in-hospital analysed retrospectively. Multivariable logistic...
To evaluate the impact of aortic root abscess (ARA) on postoperative outcomes surgically managed infective endocarditis (IE) and to inform optimal surgical approach.
Ischemia and malperfusion are strong predictors of poor postoperative outcomes in type A acute aortic dissection (TAAAD). Serum lactate is an accurate surrogate point-of-care marker malperfusion. The aim this study to investigate the correlation between lactate, in-hospital outcomes, 1-year survival following TAAAD repair.One hundred thirty-two patients underwent operative repair over a 4-year period at our institution 128 had serum measurements three stages peri-operatively-preoperatively,...
This study aimed to optimise techniques for whole transcriptome and small RNA analyses on clinical tissue samples from patients with cardiovascular disease. Clinical often represent a particular challenge extracting of sufficient quality robust sequencing analysis, due availability, it is rarely possible the themselves. Therefore, we have used equivalent pigs undergoing cardiopulmonary bypass surgery test different protocols optimal extraction, then validated in human samples. Here present...
Ero proteins are central to oxidative protein folding in the endoplasmic reticulum (ER), but their expression varies a tissue-specific manner. The aim of this work was establish Ero1α digestive system and examine behavior premalignant Barrett's esophagus, esophageal (OE) gastric cancers cancer cell lines.Ero1α is expressed columnar epithelium tissue, OE tumors tumors. Homocysteine, precursor metabolism cysteine methionine, induces active Ox1 form line OE33.These results demonstrate for first...
Background Redo sternotomy aortic root surgery is technically demanding, and the evidence on outcomes mostly from retrospective, small sample, single-centre studies. We report trend, early clinical results outcome predictors of redo replacement over 20 years in United Kingdom. Methods retrospectively analysed collected data UK National Adult Cardiac Surgery Audit (NACSA) all replacements performed between 30th January 1998 19th March 2019. trends volume operations, characteristics hospital...
Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used corrective cardiac surgery. In this study, authors evaluated advantages of graft for right ventricular outflow tract reconstruction a novel porcine model. After 4.5 months from implantation, improved myocardial strain, better endothelialization and cardiomyocyte incorporation, reduced fibrosis were observed cellularized grafts compared acellular grafts. To authors'...
There are conflicting data on choosing balloon aortic valvoplasty (BAV) or surgical valvotomy (SAV) in neonates and infants requiring intervention for valve stenosis. We aim to report the outcome of both techniques based results from UK national registry.This is a retrospective study, including all patients under 1 year undergoing BAV/SAV between 2000 2012. A modulated renewal approach was used examine effect reinterventions outcomes.A total 647 (488 BAV, 159 SAV, 292 neonates) 888...
Purpose: To describe a bailout technique to stabilize target vessel catheterization in branched endovascular aortic repair. Technique: The is demonstrated 75-year-old patient with 75-mm symptomatic type III thoracoabdominal aneurysm that was treated t-Branch endograft. If catheter cannot be advanced for exchange more stable guidewire after catheterization, the balloon-anchoring can applied through-the-branch hydrophilic guidewire. Through femoral access and wire are passed outside device...
Cardioplegic cardioprotection strategies used during paediatric open-heart surgery remain suboptimal. Sildenafil, a phosphodiesterase 5 (PDE-5) inhibitor, has been shown to be cardioprotective against ischemia/reperfusion injury in variety of experimental models and this study therefore tested the efficacy supplementation cardioplegia with sildenafil piglet model cardiopulmonary bypass arrest, using both cold warm protocols. Piglets were anaesthetized placed on coronary pulmonary (CPB),...
Background Type A acute aortic dissection (TAAAD) is rapidly fatal without emergency repair. Surgical outcomes have improved over the years with improvements in technique and postoperative care. Classically, supracomissural replacement has been standard of However, reintervention rates, particularly on root certain groups patients, shifted focus towards improving long-term results surgical With regard to root, gold standard. community realized that valve itself a disease, sparing (VSRR) took...
A 54-year-old woman with end-stage renal disease on hemodialysis access through a right arm arteriovenous fistula presented swelling. Venography demonstrated subclavian vein stenosis. balloon angioplasty of the stenotic was unsuccessful, and she subsequently underwent stent placement angioplasty. Ten days following procedure, developed acute shortness breath. Transthoracic echocardiogram migration venous into ventricle. Using an endoscopic robotic approach, successfully extracted from beating heart.
A 15-year-old patient with hypoplastic left heart syndrome underwent 3-stage palliation by the age of 3 years. He was later diagnosed Loeys-Dietz syndrome. On follow-up imaging, neoaorta dilated at 50 mm in diameter. aortic root replacement a composite valve conduit and hemiarch replacement, using boat-shaped Dacron graft. The uncertainty how univentricular circulation would tolerate long bypass time steered us away from total arch replacement. His postoperative recovery uneventful. Imaging...
Background: Type A acute aortic dissection (TAAAD) is rapidly fatal without emergency surgical. Surgical outcomes have improved over the years with improvements in technique and postoperative care. Classically, supracomissural replacement has been standard of However, reintervention rates, particularly on root, certain groups patients shifted focus towards improving long terms results surgical repair. With regard to root gold standard. community realised that valve itself a disease, sparing...
Lemierre's syndrome is an infectious phenomenon characterized by oropharyngeal infection with bacteraemia, thrombophlebitis, and distant septic emboli. Septic emboli are a recognized cause of Type 2 myocardial infarction, left ventricular pseudoaneurysm being rare but important complication this.A 19-year-old male presented acute confusion, fevers, cough. Blood cultures were positive for Fusobacterium necrophorum initial imaging showed cavitating pneumonia. Further evaluation revealed in the...
Background: The COVID-19 pandemic in late 2019 quickly stretched health care system across the globe. Mortalities, shortages capacity, and lack of experience similar circumstances required innovation way is delivered. Health systems changed operating schedules, staff work pattern, how patients are cared for. effects these changes reached patients, training different ways. Methods: We search Pubmed EMBASE for articles related to COVID-19. also searched local e-mails information provided...