A5103190153- Bone Metabolism and Diseases
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Bone and Dental Protein Studies
- Bone health and treatments
- Cancer-related gene regulation
- melanin and skin pigmentation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Research and Splicing
- Oral microbiology and periodontitis research
- Inflammation biomarkers and pathways
- Proteoglycans and glycosaminoglycans research
- Skin and Cellular Biology Research
- Glycosylation and Glycoproteins Research
- Eicosanoids and Hypertension Pharmacology
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- S100 Proteins and Annexins
- Atherosclerosis and Cardiovascular Diseases
- Pharmacogenetics and Drug Metabolism
University of California, San Diego
2023
Yamagata University
1990-2018
Nagasaki University
1994-2009
We investigated whether various recombinant cytokines induce vascular hyperpermeability when intradermally injected into rats. Only TNF did so. Of the other examined (IL-1, IL-2, granulocyte-CSF, IFN-alpha, IFN-beta, IFN-gamma) none had this effect. The increase in permeability was dose dependent, and peak response observed at 90 min after injection. When mixtures of were injected, only IL-1 IFN-gamma augmented TNF-induced hyperpermeability, occurring a dose-dependent manner. induction by...
Bone resorption is positively regulated by receptor activator of nuclear factor-kappaB ligand (RANKL). Pro-inflammatory cytokines, such as interleukin (IL)-1beta, promote RANKL expression stromal cells and osteoblasts. Green tea catechin (GTC) has beneficial effects on human health been reported to inhibit osteoclast formation in an vitro co-culture system. However, there no investigation the effect GTC periodontal bone vivo. We therefore investigated whether inhibitory lipopolysaccharide...
Background and Objective: Receptor activator of nuclear factor kappa B ligand (RANKL) is an important in osteoclast differentiation, activation survival; however, its involvement inflammatory bone resorption, with or without occlusal trauma, unclear. The purpose the present study was to investigate distribution RANKL‐expressing cells rat periodontium during lipopolysaccharide‐induced inflammation trauma. Material Methods: Lipopolysaccharide injected into gingiva lower left first molar induce...
The nuclear receptor co-repressor (NCoR) complex mediates transcriptional repression dependent on histone deacetylation by deacetylase 3 (HDAC3) as a component of the complex. Unexpectedly, we found that signaling activator factor κB (RANK) converts NCoR/HDAC3 to co-activator AP-1 and NF-κB target genes are required for mouse osteoclast differentiation. Accordingly, dominant function complexes in response RANK is activate, rather than repress, gene expression. Mechanistically, promotes...
Interleukin-1α (IL-1α) is a powerful activator of osteoclast cells. However, the underlying mechanism for this activation unknown. In study, we reveal that IL-1α up-regulates expression cathepsin K protein, key protease in bone resorption, by five-fold. Northern blot analysis and promoter show induction occurs at transcriptional level, dose-responsive time-dependent manner. No increase presence either pyrrolidine dithiocarbamate (PDTC), selective inhibitor NF-κB, or Genistein, protein...
Bronchopulmonary dysplasia (BPD), a chronic lung disease, is the most common major complication of preterm birth. Supplemental oxygen administration, while lifesaving in neonatal period, remains key determinant BPD pathophysiology. Exposure immature to increased levels elicits an inflammatory response resulting abnormal development. However, not every premature infant equally sensitive develop BPD. Using genetically diverse mouse strains, we show that innate immune activated lungs mice...
We investigated the expression of carbohydrate residues in regenerated junctional epithelium (JE) cells histopathologically with lectin staining to clarify mechanisms responsible for changes their JE derived from residual oral epithelium. Curettage and root planing procedures were performed on buccal gingival sulci rat first lower molars, connective tissues completely removed. The mandibles resected after 12 h 1, 2, 3, 4, 5, 7, 10 14 days, fixed paraformaldehyde, decalcified EDTA embedded...