A5049014074- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Porphyrin Metabolism and Disorders
- Spaceflight effects on biology
- Laser Applications in Dentistry and Medicine
- Cancer, Hypoxia, and Metabolism
- Renal Diseases and Glomerulopathies
- Neonatal Health and Biochemistry
- Polar Research and Ecology
- Skin Protection and Aging
- Systemic Lupus Erythematosus Research
- Liver Diseases and Immunity
- Protease and Inhibitor Mechanisms
- Bacteriophages and microbial interactions
- Photosynthetic Processes and Mechanisms
- Liver physiology and pathology
- Lipoproteins and Cardiovascular Health
- Atherosclerosis and Cardiovascular Diseases
- Hemoglobin structure and function
- Protein Interaction Studies and Fluorescence Analysis
Universidade Estadual de Campinas (UNICAMP)
2000-2022
The study of the interaction synthetic protoporphyrin IX (PpIXs) and extracted from Harderian glands ssp Rattus novergicus albinus rats (PpIXe) with bovine serum albumin (BSA) was conducted in water at pH 7.3 4.5 by optical absorption fluorescence spectroscopies. PpIXs is present as H- J-aggregates equilibrium themselves monomers. charge 2- 1- 4.5. This increases its aggregation shifts favor J-aggregates. In spite electrostatic attraction 4.5, where BSA positive, binding constant (Kb) to 20%...
In rats, the Harderian Gland secret Protoporphirin IX which is retained at acinar lumina. Since this photosensitizer important for PDT of malignant tumors, we propose to study gland as a model help understanding with endogenous photosensitizers. Twenty Wistar SPF adult rats were submitted surgical exposure both glands, revealing red fluorescence upon UV, characterizing protoporphirin presence. After that, one each pair (one kept control) was irradiated an 8 mW HeNe (6328 angstrom) 45...
Purpose: To show that a non-laser light source can be constructed, using 500 W Tungsten lamp and optical filters, this produces photodynamic effect via protoporphyrin IX (PpIX) similar to the produced by HeNe laser light. Methods: The broad band spectrum from was filtered. Infrared blue part of discarded absorption process fraction spectrum, centered at red portion, filtered an interference filter. Photodynamic studied activity on endogenous PpIX Harderian glands Wistar rats. Twenty rats...
To investigate red fluorescence found in the digestive tract of Wistar rats submitted to stress produced by a liquid diet 5% glucose and maintenance darkness.Protoporphyrin IX (PpIX) is Harderian gland, located inner corner eyes rats. Under stressful conditions this gland increases production PpIX, which can be detected different regions body, manner reminiscent porphyria.Sixty-five were used study. The spectra registered with optical resolution better than 1.7 nm. fed diet, exclusively, up...
Photodynamic therapy (PDT) is an emergent technique used in clinical treatments for several pathologies, which the photoactivation of photosensitizer molecule leads to cell death. Our project investigates photodynamic effect Protoporphyrin IX (PpIX), one currently most photosensitizers, prokaryotic cells, order explore its use sterilization. Atomic Force Microscopy (AFM) and Wide Field (WFM) were evaluate PDT effects on X.fastidiosa cells.