A5016733436- Drug-Induced Hepatotoxicity and Protection
- Cellular Mechanics and Interactions
- Cell Adhesion Molecules Research
- Biochemical Acid Research Studies
- Wnt/β-catenin signaling in development and cancer
- Liver Disease Diagnosis and Treatment
- Trace Elements in Health
- Liver Diseases and Immunity
- Macrophage Migration Inhibitory Factor
- Attention Deficit Hyperactivity Disorder
- Epilepsy research and treatment
- Moringa oleifera research and applications
- Child Nutrition and Feeding Issues
- Kruppel-like factors research
- Pharmacological Effects and Toxicity Studies
- Parathyroid Disorders and Treatments
- Pharmacological Effects of Natural Compounds
- Chemotherapy-induced organ toxicity mitigation
- Autism Spectrum Disorder Research
- Drug Transport and Resistance Mechanisms
- Acute Kidney Injury Research
- Cellular transport and secretion
- Curcumin's Biomedical Applications
- Fibroblast Growth Factor Research
- Liver Disease and Transplantation
Sohag University
2021-2025
Tokushima University
2012-2013
Abstract The connection between chronic kidney disease (CKD) and acute injury (AKI) is becoming more widely acknowledged, as the two conditions probably exacerbate one other. purpose of present study was to evaluate circulating levels fibroblast growth factor 23 (FGF23), αKlotho, mircoRNA-126 (miR-126) explore possible genetic role single nucleotide polymorphisms (SNPs) in klotho G-395A (rs1207568), C1818T (rs564481), wnt signaling pathway AXIN-1 C > T (rs9921222) AKI CKD patients their...
In preterm newborns, neonatal respiratory distress syndrome (RDS) is among the main causes of failure and mortality. However, effect macrophage migration inhibitory factor (MIF) on developmental lung disease not well documented in literature. Moreover, little known about effects growth differentiation factor-15 (GDF-15) maturity infants. To evaluate serum MIF GDF-15 levels infants with without RDS analyze genetic profile single nucleotide polymorphisms (SNPs) for rs755622 G>C rs4808793 C>G....
Backgrounds The incidence of non-alcoholic fatty liver disease (NAFLD) has been significantly growing in recent years. Although the pathophysiology fibrosis progression NAFLD is not yet known, oxidative stress and inflammation have known to a major role development NASH. Understanding impact micronutrients could potentially help us better understand pathogenesis. Aims Assessing serum levels Zn, Se, Vitamin E their relation hepatic patients. Methods This study included 80 patients 40 healthy...
We previously showed that R ab13 and its effector protein, junctional ab13‐binding protein ( JRAB )/molecules interacting with C as L ‐like 2 MICAL ‐L2), regulate development by modulating cell adhesion molecule transport actin cytoskeletal reorganization in epithelial cells. Here, we investigated how regulates of the cytoskeleton NIH 3T3 fibroblasts, an attempt to obtain novel insights into mechanism action. To this end, expressed mutant proteins adopt a constitutively open or closed state...
Abstract Objectives Acute kidney injury (AKI) is a critical clinical event characterized by reduction in the excretory function of kidneys. N-acetylcysteine (NAC), N-acetylmethionine (NAM) and N-acetylglucosamine (NAG) are antioxidants with scanty known genetic mechanisms. We aimed to assess both molecule-1 (KIM-1) growth-arrested DNA damage-inducible gene-153 (GADD-153) genes expression paracetamol (PA) induced AKI. Also, recognize whether NAC, NAM and/or NAG have roles altering these for...
Epilepsy is one of the most common neurological disorders, and it places a significant economic strain on healthcare system around world. Although exact mechanism epilepsy has yet to be illustrated, various pathogenic cascades involving neurotransmitters trace elements have been reported. We aimed investigate serum levels growth-associated protein-43 (GAP-43) neurotrophin-3 (NT-3) among cohort Egyptian children with correlate these biomarkers their zinc levels.This case-control study...
Verruca vulgaris is a benign hyperkeratotic proliferation of the epidermis. Few studies look at differences in serum and tissue macrophage migration inhibitory factor (MIF) levels verruca vulgaris, as well its gene polymorphisms that have yet to be explored. The current study provided in-depth evaluation MIF tissues patients with establishes for first time possible association common warts.This case-control included 50 who were diagnosed clinically warts comparison age sex-matched controls....
BACKGROUND: The specific aetiology of autism spectrum disorder (ASD) is still unclear. We aimed to evaluate the potential association between three vitamin D receptor single nucleotide polymorphisms (VDR-SNPs) [ApaI (rs7975232), TaqI (rs 731236), and BsmI (rs1544410)] with susceptibility severity autism.METHODS: current research involved 136 Egyptian children grouped into 86 autistic children, compared 50 controls. In addition clinical evaluations patients using Childhood Autism Rating Scale...
Endocrine disputer chemicals (EDCs) such as 4-tert-octylphenol (OP), are a class of exogenous pollutants that can interfere with normal physiological processes, resulting in number health issues. Therefore, the goal current study is to determine how well α -lipoic acid (LA) protects against DNA damage brought on by OP. Forty male albino rats were randomly assigned into four groups. Group I (control group) not received any material, group II (αLA-group) α-lipoic (40 mg/kg/ day), III...