A5036992312- Renal cell carcinoma treatment
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Ureteral procedures and complications
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Pediatric Urology and Nephrology Studies
- Economic and Financial Impacts of Cancer
- Immune Cell Function and Interaction
- Sexual function and dysfunction studies
- Multiple and Secondary Primary Cancers
- Healthcare and Environmental Waste Management
- Pelvic floor disorders treatments
- Pharmaceutical studies and practices
- Renal and Vascular Pathologies
- Sarcoma Diagnosis and Treatment
- Ethics and bioethics in healthcare
- Pancreatic and Hepatic Oncology Research
- Cancer Diagnosis and Treatment
Hospital Alemán
2014-2024
AC Camargo Hospital
2023
Hospital Británico
2013
Natural Killer (NK) cells play a key role in cancer immunosurveillance. However, NK from patients display an altered phenotype and impaired effector functions. In addition, evidence of regulatory for is emerging diverse models viral infection, transplantation, autoimmunity. Here, we analyzed clear cell renal carcinoma (ccRCC) datasets The Cancer Genome Atlas (TCGA) observed that higher expression signature genes associated with reduced survival. Analysis fresh tumor samples ccRCC unraveled...
Tumor-associated macrophages (TAM) are abundant in several tumor types and usually correlate with poor prognosis. Previously, we demonstrated that anti-inflammatory (M2) inhibit NK cell effector functions. Here, explored the impact of TAM on cells context clear-cell renal carcinoma (ccRCC). Bioinformatics analysis revealed an exhausted signature strongly correlated M2 signature. Analysis from human ccRCC samples confirmed they exhibited M2-skewed phenotype inhibited IFN-γ production by...
NKG2D is a major natural killer (NK) cell-activating receptor that recognizes eight ligands (NKG2DLs), including MICA, and whose engagement triggers NK cell effector functions. As NKG2DLs are upregulated on tumor cells but tumors can subvert the NKG2D-NKG2DL axis, constitute attractive targets for antibody (Ab)-based immuno-oncology therapies. However, such approaches require deep characterization of surface expression primary immune cells. Here, using bioinformatic analysis, we observed...
Background: Renal cell carcinoma (RCC) is a lethal neoplasia. Data from Latin America are scarce, and the distinct ethnic origins of this population could affect predictive or prognostic factors. Objective: We aim to describe large cohort non-metastatic renal carcinoma, identifying demographic, clinical, pathological factors for survival. Methods: used multi-institutional retrospective involving 5,670 patients who underwent radical partial nephrectomy across seven American countries Spain...
The prostate-specific antigen density (PSAD) is an accessory tool when suspecting prostate cancer. Multiparametric magnetic resonance imaging (mpMRI) of the has a high rate false negatives. aim this study to evaluate sensitivity, specificity, negative predictive value (NPV), and positive (PPV) adding PSAD or equivocal mpMRI.A retrospective that included biopsies performed using transperineal approach guided by ultrasound between 2015 2019 was conducted. Clinically significant cancer (csPCa)...
PURPOSE To assess the effect of clinical and pathological variables on cancer-specific overall survival (OS) in de novo metastatic patients from a collaborative primarily Latin American countries. PATIENTS AND METHODS Of 4,060 with renal cell carcinoma diagnosed between 1990 2015, total 530 (14.5%) had metastasis at presentation. Relationships parameters treatment-related outcomes were analyzed by Cox regression log-rank method. RESULTS patients, 184 (90.6%) died carcinoma. The median OS...
Introduction: Ejaculatory dysfunction is a common complication of surgeries for benign prostatic obstruction. It causes clear deterioration in quality life. Techniques have been developed to attempt preserve antegrade ejaculation (AE). Our objective was analyze results ejaculatory function using an AE preservation technique during anatomical vaporization with XPS 180-W. Methods: Between 2017 and 2019, sexually active patients were treated this by the same surgical team. A questionnaire...
The majority of renal cell carcinomas are now incidentally detected as small masses in asymptomatic patients due to the widespread use ultrasound and new improved noninvasive abdominal imaging modalities. Nephron-sparing surgery is treatment choice for with presence normal contralateral kidney or an anatomic functional solitary kidney. We reviewed retrospectively our experience open laparoscopic partial nephrectomy.The records all who underwent nephron-sparing a mass since 1995 at British...
Introduction Isaacs's syndrome (IS), is a rare neurological disorder, characterized by sustained muscular activity, fasciculations, cramps, myokymia, excessive sweating, and occasional elevation of creatine phosphokinase (CPK) enzyme. Aim To report our experience in patients with IS urinary manifestations, describing clinical findings, test's results, response to treatment. Methods An observational, retrospective analysis manifestations treated at German Hospital Buenos Aires between 2001...
Multiple factors can account for surgical complexity during laparoscopic partial nephrectomy (LPN); severe adhesion of perirenal fat (PRF) is a crucial one. Consequent renal decapsulation deem renorrhaphy very challenging task. We propose novel technique (synthetic capsule tailoring [SYRCT]) to facilitate in decapsulated kidneys and suggest early as safe option cases with PRF.We retrospectively analyzed perioperative results this performed PRF. All were classified high grade the Mayo...
To evaluate demographic, clinical and pathological characteristics of small renal masses (SRM) (≤ 4 cm) in a Latin-American population provided by LARCG (Latin-American Renal Cancer Group) analyze predictors survival, recurrence metastasis. A multi-institutional retrospective cohort study 1523 patients submitted to surgical treatment for non-metastatic SRM from 1979 2016. Comparisons between radical (RN) or partial nephrectomy (PN) young elderly were performed. Kaplan-Meier curves log-rank...
Objective: Most of the studies regarding natural history renal masses are based on active surveillance series and suggest that have a slow growth rate.Nevertheless, only few report time between normal computed tomography (CT) scan to first detection tumor.We aimed analyze rate in newly diagnosed kidney tumors. Material methods:We analyzed patients with enhancing developed after CT scan, which was performed at most 12 months earlier.Variables examined included patient age, gender, tumor size,...
You have accessJournal of UrologyKidney Cancer: Advanced (including Drug Therapy) II1 Apr 2017MP16-17 OUTCOMES IN OVER 4,000 PATIENTS WITH RENAL CELL CARCINOMA FROM THE LATIN AMERICAN CANCER GROUP (LARCG): A FOCUS ON METASTATIC DISEASE Diego Abreu, Guillermo Gueglio, Patricio Garcia, Walter da Costa, Daniel Beltrame, Alvaro Zuñiga, Luis Meza, Ruben Bengió, Carlos Scorticati, Ricardo Castillejos, Francisco Rodriguez, Ana Maria Autran, Carmen Gonzalez, Miguel Sanchez, Jose Gadu, Alejandro...
Introduction and Background: Urinary diversion with the endoscopic Double-J stent is a frequent procedure; complications can include irritation, suprapubic or flank pain, vesicoureteral reflux, hematuria, urinary infection. We report case of hepatic subcapsular hematoma secondary to placement. Case Presentation: A 28-year-old woman presented history Sjögren's disease, nephrocalcinosis, chronic kidney disease (CKD). The patient underwent multiple percutaneous procedures during previous 2...