A5021008509- Autophagy in Disease and Therapy
- Genetics, Aging, and Longevity in Model Organisms
- Fungal and yeast genetics research
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Polyamine Metabolism and Applications
- Fungal Infections and Studies
- Plant Gene Expression Analysis
- Microbial Community Ecology and Physiology
- Infectious Diseases and Tuberculosis
- GABA and Rice Research
- Cannabis and Cannabinoid Research
- Epigenetics and DNA Methylation
- Antifungal resistance and susceptibility
- Bacteriophages and microbial interactions
- Nail Diseases and Treatments
- Tryptophan and brain disorders
- Cultural Heritage Materials Analysis
- Traditional and Medicinal Uses of Annonaceae
- Building materials and conservation
- Tuberculosis Research and Epidemiology
- Syphilis Diagnosis and Treatment
- Agricultural pest management studies
- Scientific Computing and Data Management
- Extracellular vesicles in disease
Nawi Graz
2016-2025
University of Graz
2016-2025
Wilhelminen Hospital
2023
University of Vienna
2010-2023
Wiener Krankenanstaltenverbund
2023
Medical University of Graz
2019
Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report identification of flavonoid 4,4'-dimethoxychalcone (DMC) as a natural compound anti-ageing properties. External DMC administration extends lifespan yeast, worms flies, decelerates senescence human cell cultures,...
Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis.This process also involved the antiviral response at multiple levels, including direct elimination of intruding viruses (virophagy), presentation viral antigens, fitness immune cells, and inhibition excessive inflammatory reactions.In line its central role immunity, have evolved mechanisms to interfere or evade autophagic process, some cases, even harness autophagy constituents machinery for their...
The metabolite α-ketoglutarate is membrane-impermeable, meaning that it usually added to cells in the form of esters such as dimethyl (DMKG), trifluoromethylbenzyl (TFMKG) and octyl (O-KG).Once these compounds cross plasma membrane, they are hydrolyzed by esterases generate α-ketoglutarate, which remains trapped within cells.Here, we systematically compared DMKG, TFMKG O-KG for their metabolic functional effects.All three similarly increased intracellular levels yet each them had multiple...
The publication and scientific implementation of scholarly articles is a collaborative effort that unites readers, authors, editors, referees. A journal thereby serves as vital platform, enabling these interactions fostering shared commitment to advancing the quality impact communication. In this short editorial, we celebrate milestone publishing 500th article in Microbial Cell by highlighting collective efforts. Importantly, from outset more than ten years ago, have cultivated handcrafted...
(2E)-2-(6-hydroxyhexyliden)cyclopropyl-β-glucopyranoside (1) was isolated from the rhizomes of tree fern Metaxya rostrata, Metaxyaceae, a Costa Rican traditional herbal remedy against intestinal diseases [1]. Literature research for similarity structural characteristics resulted in different related compounds with very uncommon part methylenecyclopropane [2,3,4], which showed anti-viral activitiy Epstein-Barr-, Human Herpes-, Hepatitis B-, Immunodeficiency- and Cytomegalo-virus vitro. Thus,...
Hintergrund Die Tuberkulose der peripheren Lymphknoten stellt die häufigste extrathorakale Tuberkulose-Manifestation bei Kindern dar und betrifft vor allem cervikalen Lymphknoten1. Im Nationalen Referenzzentrum für Kindertuberkulose, Klinik Ottakring, wurden in den Jahren 2015-2021 insgesamt 193 Patienten mit aktiver stationär behandelt. Von diesen handelte es sich 6 Fällen um eine peripherer Lymphknoten. klinischen Alltag kann Unterscheidung von anderen Ursachen (u.a. Infektionen...