A5057438498- Computational Drug Discovery Methods
- Phytochemicals and Medicinal Plants
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Epigenetics and DNA Methylation
- Protein Structure and Dynamics
- Lung Cancer Treatments and Mutations
- Genetic Associations and Epidemiology
- Genomics and Phylogenetic Studies
- Digital Imaging for Blood Diseases
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and biological activity
- RNA and protein synthesis mechanisms
- Genomic variations and chromosomal abnormalities
- Microbial Natural Products and Biosynthesis
- Lung Cancer Diagnosis and Treatment
- Pharmacological Effects of Medicinal Plants
- Pulmonary Hypertension Research and Treatments
- Galectins and Cancer Biology
- Mycobacterium research and diagnosis
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- Transgenic Plants and Applications
- Bioinformatics and Genomic Networks
- Click Chemistry and Applications
Brigham and Women's Hospital
2022-2024
Indian Institute of Technology Delhi
2017-2023
Harvard University
2023
University of Delhi
2015
Delhi Technological University
2014
Brassica juncea var. Varuna is an economically important oilseed crop of family Brassicaceae which vulnerable to abiotic stresses at specific stages in its life cycle. Till date no attempts have been made elucidate genome-wide changes transcriptome against high temperature or drought stress. To gain global insights into genes, transcription factors and kinases regulated by these explore information on coding transcripts that are associated with traits agronomic importance, we utilized a...
Abstract Background Survival and drug response are two highly emphasized clinical outcomes in cancer research that directs the prognosis of a patient. Here, we have proposed late multi omics integrative framework robustly quantifies survival for breast patients with focus on relative predictive ability available datatypes. Neighborhood component analysis (NCA), supervised feature selection algorithm selected relevant features from multi-omics datasets retrieved The Cancer Genome Atlas (TCGA)...
Abstract Withaferin-A is a withanolide, predominantly present in Ashwagandha ( Withania somnifera ). It has been shown to possess anticancer activity variety of human cancer cells vitro and vivo . Molecular mechanism such cytotoxicity not yet completely understood. Withanone were earlier activate p53 tumor suppressor oxidative stress pathways cells. 2,3-dihydro-3β-methoxy analogue (3βmWi-A) was lack well tolerated at higher concentrations. It, on the other hand, protected normal against...
The anticancer activities of Withaferin-A (Wi-A) and Withanone (Wi-N) from Ashwagandha Caffeic Acid Phenethyl Ester (CAPE) honeybee propolis have been well documented. Here, we examined the binding potential these natural compounds to inhibit constitutive phosphorylation epidermal growth factor receptors (EGFRs). Exon 20 insertion mutants EGFR, which show resistance various FDA approved drugs are linked poor prognosis lung cancer patients, were primary focus this study. Apart exon mutants,...
Withaferin-A (Wi-A) has been shown to possess anticancer activity. Molecular mechanism(s) of its action not fully resolved. We recruited low dose Wi-A that caused slow growth arrest in cancer cells and was relatively safe for normal cells. Consistently, we detected nuclear translocation factor kappa B (NFκB) activation p38MAPK selectively Bioinformatics analyses revealed did disrupt IKKα/IKKβ–Nemo complex regulates NFκB However, it moderate change the conformation IKKβ–Nemo interacting...
Withaferin-A (Wi-A), a secondary metabolite extracted from Ashwagandha (Withania somnifera), has been shown to possess anticancer activity. However, the molecular mechanism of its action and signaling pathways have not yet fully explored. We performed an inverse virtual screening investigate binding potential catalytic site protein kinases identified ABL as strong candidate. Molecular docking dynamics simulations were undertaken effects on BCR-ABL oncogenic that is constitutively activated...
The anti-metastatic and anti-angiogenic activities of triethylene glycol derivatives have been reported. In this study, we investigated their molecular mechanism(s) using bioinformatics experimental tools. By dynamics analysis, found that (i) dimethacrylate (TD-10) tetraethylene (TD-11) can act as inhibitors the catalytic domain matrix metalloproteinases (MMP-2, MMP-7 MMP-9) by binding to S1’ pocket MMP-2 MMP-9 Zn ion site MMP-7, (ii) TD-11 cause local disruption secondary structure vascular...
Rationale: Rheumatoid arthritis (RA) has been implicated in interstitial lung disease (ILD) as majority of studies have comprised patients with known RA. However, it remains unclear whether an underlying risk for RA combination genetic pulmonary fibrosis is associated radiological markers early injury and broader population samples. Objective: Determine serological biomarkers the MUC5B (rs35705950) allele (T) are abnormalities (ILA) on computed tomography (CT) scans. Methods: Associations...
Serine/threonine-protein kinase B-raf (BRAF) plays a significant role in regulating cell division and proliferation through MAPK/ERK pathway. The constitutive expression of wild-type BRAF (BRAFWT) its mutant forms, especially V600E (BRAFV600E), has been linked to multiple cancers. Various synthetic drugs have approved are clinical trials, but most them reported become ineffective within short duration. Therefore, combinational therapy involving often recruited for cancer treatment. However,...
Abstract Lung function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry GWAS meta-analysis of lung to date, comprising 580,869 participants, 1020 independent association signals identified 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age smoking groups, collectively as genetic risk...
Emphysema and chronic obstructive pulmonary disease (COPD) most commonly result from the effects of environmental exposures in genetically susceptible individuals. Genome-wide association studies have implicated ADGRG6 COPD reduced lung function, a limited number examined role cells representative airway. However, locus is also associated with DLCO/VA, an indicator gas exchange efficiency alveolar function. Here, we sought to evaluate mechanistic contributions homeostatic function type 2...
Background: Lung adenocarcinoma (LUAD) patients majorly tend to poor clinical outcomes. A biomarker or gene signature built using multi-omics dataset along with features that could predict survival in these would have a significant impact, enabling earlier detection of mortality risk and personalized therapy. Methods: To identify novel associated overall survival, we analyzed LUAD patient's single omics datasets for Copy number variations (CNV), protein, methylation, mutation, RNA, mi-RNA...
Recent developments in whole–genome sequencing technology have introduced to us, completely determined genome sequences of many individuals, called 'personal genomes'. As personal is being commoditised, the necessity discover sequence dissimilarities increasing, facilitate clinical diagnostic studies. For this we need knowledge regions containing duplications, rearrangements and large scale gain loss sequences. Apart from that storage retrieval such a varied dataset basic analysis genomic...