A5110198165- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Hepatitis C virus research
- Colorectal and Anal Carcinomas
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Hepatitis B Virus Studies
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Biosimilars and Bioanalytical Methods
- Evolutionary Algorithms and Applications
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Biomarkers in Disease Mechanisms
- Metaheuristic Optimization Algorithms Research
- Imbalanced Data Classification Techniques
- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Thyroid Cancer Diagnosis and Treatment
- Multiple Sclerosis Research Studies
The University of Texas MD Anderson Cancer Center
2024
The University of Texas Southwestern Medical Center
2023
Columbus Oncology and Hematology Associates
2023
Clovis Oncology (United States)
2022
University of North Carolina at Chapel Hill
2015-2016
Carolina Institute for NanoMedicine
2016
Takeda (United States)
2015
University of North Carolina Health Care
2015
Hoag Memorial Hospital Presbyterian
2011
Genesys (United States)
2007-2008
Abstract Purpose: This trial evaluated the safety, clinical activity, and immunogenicity of an allogeneic cellular immunotherapy in 55 chemotherapy-naïve patients with hormone-refractory prostate cancer (HRPC). The immunotherapy, based on GVAX platform, is a combination two carcinoma cell lines modified granulocyte macrophage colony-stimulating factor (GM-CSF) gene. Experimental Design: HRPC radiologic metastases (n = 34) or rising prostate-specific antigen (PSA) only 21) received prime...
This paper presents a study on hierarchical surrogate-assisted evolutionary algorithm (HSAEA) using different global surrogate models for solving computationally expensive optimization problems. In particular, we consider the use of Gaussian process (GP) and polynomial regression (PR) methods approximating fitness landscape in search. The model serves to pre-screen EA population promising individuals. Subsequently, these potential individuals undergo local search form Lamarckian learning...
Novel agents are needed to improve chemoradiotherapy for locally advanced rectal cancer. In this study, we assessed the ability of CRLX101, an investigational nanoparticle-drug conjugate containing payload camptothecin (CPT), therapeutic responses as compared with standard chemotherapy. CRLX101 was evaluated a radiosensitizer in colorectal cancer cell lines and murine xenograft models. potent CPT vitro its radiosensitize cells. Evaluations vivo demonstrated that addition significantly...
Background: The RET gene point mutation is the main molecular alteration involved in medullary thyroid carcinoma (MTC) tumorigenesis. Previous studies Vietnam mainly consisted of case reports, with limited data on larger sample sizes. In this study, we investigated mutations exons 10, 11, and 16 analyzed clinicopathological features a series Vietnamese MTC patients. Methods: We collected 33 tissue samples from patients using Sanger sequencing method. relationship between hotspot (exons 16)...
Abstract A number of small charged carbohydrate moieties have been associated with inflammation and cancer. However, the development therapeutic Abs targeting these has hampered by their low immunogenicity structural relationship to self-Ag. We report design an Ab repertoire enriched in binding carbohydrates construction a human Fab phagemid library, “FAB-CCHO.” This library combines L chain Ig sequences from donors H synthetic diversity constructed key Ag contact sites CDRs 1, 2, 3...
The RET proto-oncogene has been implicated in breast cancer, and the studies herein describe preclinical safety assessment of an anti-RET antibody-drug conjugate (ADC) being developed for treatment cancer.RET protein expression was analyzed tumor samples using tissue microarrays. fully human antibody (Y078) conjugated to DM1 DM4 derivatives potent cytotoxic agent maytansine thioether disulfide linkers, respectively. resulting compounds, designated Y078-DM1 Y078-DM4, were evaluated antitumor...
No AccessJournal of UrologyAdult Urology1 Nov 2008Treatment Biochemical Recurrence Prostate Cancer With Granulocyte-Macrophage Colony-Stimulating Factor Secreting, Allogeneic, Cellular Immunotherapy Walter J. Urba, John Nemunaitis, Fray Marshall, David C. Smith, Kristen M. Hege, Jia Ma, Minh Nguyen, and Eric Small UrbaWalter Urba Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, Oregon , NemunaitisJohn Nemunaitis Mary Crowley Dallas, Texas MarshallFray...
Lucitanib is a multi-tyrosine kinase inhibitor whose targets are associated with angiogenesis and other key cancer immune pathways. Its antiangiogenic properties understood, but lucitanib's immunomodulatory activity heretofore unknown. exhibited such in vivo, increasing CD3 + , CD8 CD4 T cells decreasing dendritic monocyte-derived suppressor mouse spleens. Depletion of from syngeneic MC38 colon tumor-bearing mice reduced the antitumor efficacy lucitanib revealed T-cell-dependent component...
Monoclonal antibody (mAb) delivery by gene transfer in vivo may be an attractive alternative to current mAb therapies for applications that require long-term therapy. This article describes a system allows inducible high-level expression of unmodified mAbs vivo. A recombinant adeno-associated viral (rAAV) vector is used comprises cassette consisting dimerizer-regulated promoter drives the heavy and light chains linked 2A self-processing peptide furin cleavage site. Following intravenous...
Has many inhibitory functions.• PD-1 expression is hallmark of T cell exhaustion.• Plays a role in activation and proliferation• Cancer cells expressing high levels PD-L1 are able to inhibit effectively escape the response. •PD-L1 -LigandWhat application efficacy programmed death 1 protein utilizing immunohistochemical staining as diagnostic tool for Non-Small Cell Lung Pancreatic Cancer?
BACKGROUND: Head and neck lymphedema (HNL) after head cancer treatment can significantly impact patient quality of life by causing difficulty with swallowing speech, increasing cost treatment, leading to facial disfiguration, decreasing psychosocial wellness. Currently, The M. D. Anderson Cancer Center (MDACC) HNL evaluation protocol is the most commonly used tool evaluate severity status utilizing a series face tape measurements. However, there no gold standard assessment that reliably...
Methyl-branched fatty acids present in the integument of German cockroach, Blattella germanica, were identified by gas chromatography-mass spectrometry their methyl esters and reduction products (alkanes) as n-3-, n-4-, n-5-, n-7-, n-8-, n-9-monomethyl n-5,9-, n-3,9-, n-3,11-dimethyl with 16 to 20 total carbons. These have same branching patterns do major hydrocarbons this insect, including 3,11-dimethylnonacosane, precursor contact sex pheromone, are presumed be intermediates hydrocarbon...
e13525 Background: Mitomycin C (MMC) is a potent radiosensitizer and well-established agent in chemoradiotherapy (CRT) for anal cancer localized bladder cancer. However, its use often limited by toxicity. Promitil pegylated liposomal formulation of MMC lipid-based prodrug (MLP), activated thiolytic cleavage, that has shown significantly improved toxicity profile preclinical phase I clinical investigations. We hypothesized can improve the therapeutic index CRT. In this study, was compared to...
35 Background: In men with high grade PC and rapid PSA progression after RP, failure rates are unacceptably despite salvage RT. Androgen deprivation therapy (ADT) is not curative in this setting we thus evaluated a novel multi-modality approach of systemic chemotherapy anti-angiogenic prior to prostate bed RT multicenter trial. Methods: Eligible had rising 0.1-3.0 ng/ml within 4 years no metastatic disease except resected positive nodes, ADT, Gleason 7-10. Men received cycles docetaxel 70...
645 Background: There has been great interest in developing novel agents and strategies to improve chemoradiotherapy (CRT) for locally advanced rectal cancer. Irinotecan, a camptothecin (CPT) analogue, held high potential, but the combination was clinically infeasible due severe gastrointestinal toxicities. CRLX101, dynamically tumor targeted nanoparticle-drug conjugate differentially delivers CPT into cancer cells appears durably suppress HIF-1α as well topoisomerase 1, with less toxicities...
Abstract Background: There has been great interest in developing novel agents and strategies to improve chemoradiotherapy (CRT) for locally advanced rectal cancer. Irinotecan, a campothecin (CPT) analogue, held high potential, but the combination was clinically infeasible due severe gastrointestinal toxicities. CRLX101, is an investigational nanoparticle drug conjugate (NDC). Preclinical experiments showed that CRLX101 differentially delivers CPT into cancer cells appears durably suppress...
This series of FactFinders presents a brief summary the evidence and outlines recommendations to improve our understanding management several potential procedure-related complications. The in support following facts is presented: (1)