A5075677773- Birth, Development, and Health
- Sepsis Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrest and Resuscitation
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Traumatic Brain Injury and Neurovascular Disturbances
- Nitric Oxide and Endothelin Effects
- MicroRNA in disease regulation
- Cerebrovascular and Carotid Artery Diseases
- Body Contouring and Surgery
- Bariatric Surgery and Outcomes
- Circular RNAs in diseases
- Intracranial Aneurysms: Treatment and Complications
- Advancements in Battery Materials
- Obesity and Health Practices
- Mechanical Circulatory Support Devices
- Aldose Reductase and Taurine
- S100 Proteins and Annexins
- Transplantation: Methods and Outcomes
- Lipoproteins and Cardiovascular Health
- Acute Ischemic Stroke Management
- Semiconductor materials and interfaces
- Electrical and Thermal Properties of Materials
California Institute of Technology
2024-2025
Peking University First Hospital
2020-2024
Peking University
2020-2024
Guangxi Medical University
2023
Tsinghua University
2019-2022
State Key Laboratory of New Ceramics and Fine Processing
2019-2022
Shanghai Eighth People Hospital
2020-2022
Nanchang University
2018
First Affiliated Hospital of Nanchang University
2018
Second Affiliated Hospital of Nanchang University
2018
Cardiovascular dysfunction as a result of sepsis is the leading cause death in critically ill. Cardiomyocytes respond to infectious pathogens with Toll-like receptor–initiated proinflammatory response conjunction decrease contractility, although downstream events linking receptor activation and reduced cardiac contractility remain be elucidated. Using microarray analysis tissue exposed systemic lipopolysaccharide (LPS), we discovered that 2 small calcium-regulating proteins (S100A8 S100A9)...
Sepsis is the leading cause of death in critically ill patients. While decreased Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) function improves clinical outcomes murine and human sepsis, mechanisms involved have not been fully elucidated. We tested hypothesis that lipopolysaccharide (LPS), major Gram-negative bacteria endotoxin, cleared from circulation by hepatocyte Low Density Lipoprotein Receptors (LDLR)—receptors downregulated PCSK9. directly visualized LPS uptake found rapidly...
Targeted next-generation sequencing (tNGS) has emerged as a rapid diagnostic technology for identifying wide spectrum of pathogens responsible pulmonary infections.
Two-photon polymerization (2PP) is becoming increasingly established as additive manufacturing technology for microfabrication due to its high-resolution and the feasibility of generating complex parts. Until now, high resolution 2PP also bottleneck, it limited throughput therefore restricted application production microparts. Thus, mechanical properties materials can only be characterized using nonstandardized specialized microtesting methods. Due recent advances in technology, now possible...
Background: Toll-like receptors (TLRs) are expressed on cardiomyocytes and recognize pathogen-associated molecular patterns. Whether endogenous molecules produced by tissue injury (damage associated patterns, DAMPs) can induce cardiomyocyte inflammation via TLR signalling pathways and/or reduce contractility is unknown. Methods Results: Primary isolated from nuclear factor κ B (NFκB)-luciferase knock-in mice were used to assess NFκB signalling. DAMPs, HSP60, HSP70 HMGB1, increased...
The complex and uncontrolled morphological evolution of lithium metal at the interface with solid-state electrolytes limits performance batteries, leading to inhomogeneous reactions contact loss. Inspired by biological morphogenesis, we introduce a new interfacial self-regulation concept in which deformable secondary phase dynamically aggregates response local electro-chemo-mechanical stimuli, serving enhance contact. Stripping electrode containing 5-20% redox-inactive sodium domains causes...
Arginine vasopressin is a vasoactive drug commonly used in distributive shock states including mixed with cardiac component. However, the direct effect of arginine on function ischemia/reperfusion injured heart has not been clearly elucidated.We measured left ventricular ejection fraction using trans-thoracic echocardiography C57B6 mice, both normal controls and following injury induced by one hour ligation anterior descending coronary artery. Mice were treated saline, dobutamine (8.33...
Background and Aims: Cognitive impairment is one of the major complications subarachnoid hemorrhage (SAH) closely associated with neuroinflammation. Hydrogen sulfide (H2S) has been shown to have an anti-inflammatory effect reduce cognitive in neurodegenerative diseases, but its effects SAH little studied. This study aimed investigate H2S on after possible underlying mechanisms. Methods: Forty-eight male SD rats were randomly divided into three groups: a sham group, SAH+NaHS (an donor) group....
Hypotension and hypoperfusion during septic shock may contribute to tissue hypoxia the intramyocardial inflammatory response that results in myocardial dysfunction. Therefore, we hypothesized crystalloid or colloid resuscitation alter dysfunction.Randomized, controlled, prospective animal study.University laboratory.Sprague-Dawley rats (250-300 g, n = 6/group).Rats received an intraperitoneal injection of 10 mg/kg lipopolysaccharide control. One hour later, were randomized intravenous either...
Objectives To assess the predictive significance of quantitative perfusion parameters from contrast‐enhanced ultrasound (CEUS) for therapeutic response to high‐intensity focused (HIFU) ablation in patients with uterine fibroids. Methods A total 263 single fibroids were treated HIFU under guidance. The arrival time, peak enhancement intensity, and rate evaluated pretreatment CEUS. According a nonperfused volume ratio evaluation by posttreatment magnetic resonance imaging, all assigned groups...
Cardiomyocytes exposed to inflammatory processes express intracellular adhesion molecule-1 (ICAM-1). We investigated whether fibrinogen and degradation products, including D-dimer, could alter cardiomyocyte contractile function through interaction with ICAM-1 found on inflamed cardiomyocytes. In vivo, rats were injected endotoxin model systemic inflammation, whereas isolated rat cardiomyocytes treated tumor necrosis factor-alpha the environment seen following exposure bacterial products such...
To determine if overweight/obese pregnant women have altered microRNA expression patterns in fetal umbilical cord blood that may affect the development of offspring.Umbilical samples were obtained from fetuses 34 and 32 normal-weight after delivery. Next generation sequencing (NGS) analyzed their miRNA patterns. miRanda TargetScan databases used to predict miRNAs' target genes followed by analyses Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) perform function grouping pathway...
Fluid resuscitation to improve delivery of oxygen vital organs is a principal clinical intervention for septic patients. We previously reported that albumin in rat endotoxemia improved contractility isolated cardiomyocytes, but whether this effect occurs vivo unknown. hypothesized would decreased ventricular and myocardial tissue oxygenation vivo.Randomized, controlled, prospective animal study.University laboratory.Male Sprague-Dawley rats (250-350 g).Rats were randomized into three groups:...
The efficacy of stem cell (SC) transplantation in patients with type 1 diabetes mellitus (T1DM) has remained to be fully elucidated. In the present study, a systematic review and meta-analysis was performed determine clinical outcomes. Electronic databases, including PubMed, MEDLINE, WanFang Cochrane Library were screened for relevant studies published until January 13, 2018. references retrieved papers, reviews trial registries manually additional papers. Two authors involved screening...
We have recently described that Notch activates nitric oxide (NO) signaling in the embryonic endocardium. Both and NO been shown to be important during adult arteriogenesis. has required for remodeling of collateral vessels, whereas is initial vasodilatory response ischemia. Whether also an impact on phase arteriogenesis after ischemia not known. tested hypothesis endothelial cell-Notch function induction vasodilation, vasculature.We observed a significant decrease levels dorsal aorta using...
The main aim was to investigate whether or not day-3 embryo grade could predict day-5 blastocyst transfer outcomes in patients with good prognosis. This study included 233 elective single transfers (eSBT) by D5 selection conventional morphology (CM) and 121 time-lapse monitoring system (TL) from October 2016 2017. All the were submitted controlled ovarian stimulation (COS) long-term protocol transferred for first time. outcome measures clinical pregnancy rates (CPR) ongoing (OPR). Our...
Abstract Background Over the past few decades, global maternal obesity prevalence has rapidly increased. This condition may induce long-lasting pathophysiological effects on either fetal or infant health that could be attributable to unknown unique changes in umbilical blood composition. Methods A total of 34 overweight/obese and 32 normal-weight pregnant women were recruited. Fifteen samples including 8 subjects 7 normal weight sequenced using Targeted Bisulfite Sequencing technology detect...