A5010517913- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Antimicrobial Peptides and Activities
- Microbial Community Ecology and Physiology
- Methane Hydrates and Related Phenomena
- Seaweed-derived Bioactive Compounds
- Ethnobotanical and Medicinal Plants Studies
- Microbial Metabolism and Applications
- Plant Pathogenic Bacteria Studies
- Fluorine in Organic Chemistry
- Biochemical and Structural Characterization
- Bacterial Genetics and Biotechnology
- Indigenous Health, Education, and Rights
- Phytochemistry and Bioactive Compounds
- Plant-Microbe Interactions and Immunity
- Biological Control of Invasive Species
- Steroid Chemistry and Biochemistry
Tianjin University
2019-2024
University of Newcastle Australia
2014-2021
Tianjin University of Science and Technology
2021
The current investigation sought to explore the nature of secondary metabolites in algae, Laurencia pacifica.This report details first isolation sesquiterpenes isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), 10α-hydroxyldebromoepiaplysin (6), and previously unknown 10-bromo-3,7,11,11-tetramethylspiro[5.5]undeca-1,7-dien-3-ol (7) from pacifica. Isoaplysin (1) (4) showed promising levels growth inhibition against a panel cancer-derived...
Chemical investigation of a Pseudomonas aeruginosa strain isolated from Hebei, China, led to the isolation suite quinolones, quinolone-N-oxides, and phenazines, structures which were elucidated by detailed spectroscopic analysis. Most notable among secondary metabolites was an unprecedented 4-quinolone containing S-methyl group in side chain new derivative including phenyl ring chain, expand significantly variety structural motifs found quinolones raise interesting questions about their biosynthesis.
A chemical investigation of a Chinese Pseudomonas aurantiaca strain has yielded new benzoquinone (4) and furanone (5), in addition to the known dialkylresorcinols 1 2. Extensive decomposition studies on major metabolite produced an additional derivative (6), hydroxyquinone (7), two unusual resorcinol dimers (8 9). Structures were elucidated by nuclear magnetic resonance spectroscopy combination with tandem mass spectrometry analysis. These illustrate potential artifacts as source diversity....
The bacillamides are a class of indole alkaloids produced by the Bacillus genus that possess significant antialgal activity. Incorporation fluorine into was carried out using precursor-directed biosynthesis approach, with 4-, 5-, and 6-fluorotryptophan added to growing cultures atrophaeus IMG-11. This yielded corresponding fluorinated analogues A C, in addition new derivatives related metabolite N-acetyltryptamine, thus demonstrating degree plasticity bacillamide biosynthetic pathway. were...
Plants from the family Myoporaceae, which includes genus Myoporum, are extremely prized by Australian Aboriginal people for their medicinal properties. Leaves a plant, was subsequently identified as Myoporum montanum, were provided chemical investigation representatives of an community Northern Tablelands district northern New South Wales, Australia. Acetone extraction leaves complex mixture compounds including sesquiterpene hydrocarbons and more polar furanosesquiterpenes, gas–liquid...
The emergence of drug resistant microbes over recent decades represents one the greatest threats to human health; resilience many these organisms can be attributed their ability produce biofilms. Natural products have played a crucial role in discovery, with microbial natural particular proving rich and diverse source antimicrobial agents. During activity screening, strain Pseudomonas mosselii P33 was found inhibit growth multiple pathogens. Following chemical investigation this strain,...