A5101586416- Nuclear Engineering Thermal-Hydraulics
- Nuclear reactor physics and engineering
- Heat Transfer and Boiling Studies
- Heat Transfer and Optimization
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Nuclear Materials and Properties
- Heat transfer and supercritical fluids
- Combustion and Detonation Processes
- Metal complexes synthesis and properties
- Microwave-Assisted Synthesis and Applications
- Crystallography and molecular interactions
- Catalytic Cross-Coupling Reactions
- Vanadium and Halogenation Chemistry
- Crystal structures of chemical compounds
- Chemical Reactions and Isotopes
- Aerosol Filtration and Electrostatic Precipitation
- Cyclone Separators and Fluid Dynamics
- RNA and protein synthesis mechanisms
- Graphite, nuclear technology, radiation studies
- Biochemical and Molecular Research
- Metalloenzymes and iron-sulfur proteins
- Soil, Finite Element Methods
- Plant-derived Lignans Synthesis and Bioactivity
- Traditional and Medicinal Uses of Annonaceae
Ningxia University
2024-2025
Harbin Engineering University
2020-2024
Jinan University
2022-2024
China General Nuclear Power Corporation (China)
2023
Chang'an University
2023
Tsinghua University
2017-2018
Jingchu University of Technology
2009-2013
Xidian University
2012
Northwest A&F University
2009-2010
Xi'an University of Technology
2009
Owing to their remarkable pharmaceutical properties compared those of noncovalent inhibitors, the development targeted covalent inhibitors (TCIs) has emerged as a powerful method for cancer treatment. The K-Ras mutant, which is prevalent in multiple cancers, been confirmed be crucial drug target treatment various malignancies. However, although K-Ras(G12D) mutation present up 33% mutations, no targeting have developed date. relatively weak nucleophilicity acquired aspartic acid (12D) residue...
Glutathione peroxidase 4 (GPX4) emerges as a promising target for the treatment of therapy-resistant cancer through ferroptosis. Thus, there is broad interest in development GPX4 inhibitors. However, majority reported inhibitors utilize chloroacetamide reactive electrophilic warhead, and selectivity pharmacokinetic properties still need to be improved. Herein, we developed compound library based on novel sulfonyl ynamide, executed phenotypic screening against pancreatic cell lines. Notably,...
Staphylococcus aureus (S. aureus) is a major zoonotic pathogen. To investigate CRISPR carriage in S. isolates from cows with mastitis and the role of system efflux pumps antibiotic resistance. We analyzed resistance genes loci, sequenced spacers, assessed correlations between (Clustered Regularly Interspaced Short Palindromic Repeats) presence 234 isolates. The changes sequences were examined by continuous passage 360 generations without pressure. Subsequently, variations loci transcript...
Natural plant extracts have demonstrated significant potential in alternative antibiotic therapies. Cinnamaldehyde (CA) has garnered considerable attention as a natural antibacterial agent. In this study, Tandem mass tag (TMT) quantitative proteomics combined with Western blot and RT-qPCR methods were employed to explore the mechanism of CA against Methicillin-Resistant
Abstract Two new dioxomolybdenum(VI) complexes, [MoO2L1(CH3OH)]·CH3OH (1) and [MoO2L2(CH3OH)] (2), where L1 L2 are dianionic forms of N’-(3-bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide N’-(2-hydroxybenzylidene)-2-hydroxy-3-methylbenzohydrazide, respectively, have been synthesized. The complexes characterized by elemental analyzes, IR spectra, molar conductance data, single crystal X-ray determination. Mo in each complex is octahedral. crystals the stabilized hydrogen bonds weak π...
Janus kinase 3 (JAK3) is a potential target for the treatment of hematological malignancies. Herein, we report discovery series new orally bioavailable irreversible JAK3 inhibitors. The representative compound 12n potently inhibited activity with an IC50 value 1.2 nM and was more than 900-fold selective over JAK1, JAK2, Tyk2. Cell-based assays revealed that significantly suppressed phosphorylation downstream effectors STAT3/5 also robustly restrained proliferation BaF3 cells transfected...
Abstract Marine nuclear power equipment is an important support to solve the problems of long-lasting energy supply in development far-reaching marine resources and “carbon emission reduction” field. The additional force under ocean environment will lead change flow field characteristics tube bundle structures steam generator equipment, which consequence flow-induced vibration characteristics, safety system be tested. In order study conditions, taking square structure as research object,...