A5009493706- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Diagnosis and Treatment of Venous Diseases
- Healthcare Systems and Technology
- Wound Healing and Treatments
- Central Venous Catheters and Hemodialysis
- Cardiovascular Health and Disease Prevention
- Infectious Aortic and Vascular Conditions
- Patient-Provider Communication in Healthcare
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Angiogenesis and VEGF in Cancer
- Nitric Oxide and Endothelin Effects
- Space exploration and regulation
- Vascular anomalies and interventions
- Renal and Vascular Pathologies
- Diabetic Foot Ulcer Assessment and Management
- Advanced X-ray and CT Imaging
- Coronary Interventions and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Spaceflight effects on biology
University Hospital Limerick
2017-2025
University of Limerick
2019-2024
Institute for Biomedical Engineering
2023
ETH Zurich
2023
London Borough of Camden
2020
St. Michael's Hospital
2014-2020
RELX Group (United States)
2020
Peter MacCallum Cancer Centre
2003-2018
Royal College of Surgeons in Ireland
2003-2013
Beaumont Hospital
2004-2013
The oxygenase domain of inducible NO synthase (residues 1−498, iNOSox) is the enzyme's catalytic center. Its active form a homodimer that contains heme and tetrahydrobiopterin (H4biopterin) binds l-arginine [Ghosh, D. K., & Stuehr, J. (1995) Biochemistry 34, 801]. To help identify protein residues involved in prosthetic group dimeric interaction, we expressed H4biopterin-free iNOSox Escherichia coli. was 80% but contained low-spin iron bound DTT as sixth ligand. H4biopterin or with high...
Patients with significant peripheral arterial disease (PAD) face many challenges wound healing. This is primarily due to lack of adequate blood flow a site allow effective Restoration may require surgical as well medical interventions. Consequently, patients PAD have wounds in addition pre-existing ulcers they on presentation vascular service. A holistic approach assessment and care planning crucial optimise case study outlines the importance using advanced therapies evidence-based achieve...
Type 1 diabetics have a well-recognised risk of accelerated cardiovascular disease. Even in the absence clinical signs there are detectable abnormalities conduit vessel function. Our group has previously reported reversal endothelial dysfunction with pravastatin. In young asymptomatic smokers, taurine supplementation beneficial impact on macrovascular function, assessed by FMD, and shows an up-regulation nitric oxide from monocyte—endothelial cell interactions. We hypothesise that reverses...
Purpose General practitioners (GPs) play a critical role in the treatment of patients with cancer; yet often lack information for optimal care. We developed standardized GPs about chemotherapy (CT). In randomized controlled trial we assessed impact sending, by fax, tailored to particular patient's CT regimen. Primary end points were: confidence treating who were receiving (confidence), knowledge adverse effects and reasons refer patient center (knowledge), satisfaction shared care...
Objectives: Comparative effectiveness of fenestrated endovascular aneurysm repair (FEVAR) and chimney graft (ChEVAR) for juxtarenal aortic aneurysms (JAAs) remains unclear. Our objective was to identify analyze the current body evidence comparing both techniques JAA. Methods: We performed a systematic review meta-analysis FEVAR ChEVAR JAA repair. searched MEDLINE, EMBASE, Cochrane Register Controlled Trials from January 1, 1990, randomized non-randomized studies assessing outcomes Screening,...
This case study series outlines the use of Novosorb biodegradable temporising matrix (BTM, PolyNovo, Australia) in management 22 patients, each with a complex wound who attended vascular department University Hospital Limerick between 2021 and 2023. The majority patients presented acute conditions (e.g. necrotising fasciitis, crush injuries, compartment syndrome) that initially required high dependency level care. wounds (21/22, 95%) affected leg or foot, one was on chest wall. Each patient...
Oxidative stress on the renal tubules has been implicated as a mechanism of injury in both hyperglycemia and contrast-induced nephrotoxicity. The purpose this study was to determine whether combination these effects synergistic effect accentuating tubular apoptosis therefore increasing risk nephrotoxicity.Dog kidney cells were incubated with 5- 30-mmol/L glucose solutions no then exposed for 2 hours three types contrast media-high osmolar (370 mg I/mL), low (300 isoosmolar (320 I/mL)-and...
Background Complementary and alternative medicines (CAM) use is increasing, particularly in patients with a cancer diagnosis. When taken alone, many CAM are safe, but when concurrently chemotherapy, radiotherapy or prior to surgery, serious side effects interactions may occur. Aim To determine the magnitude of among receiving chemotherapy at metropolitan hospital. assess impact pharmacists providing personalised evidence-based information regarding safety conventional anticancer treatment....
The last two decades have seen increasing adoption of minimally invasive approaches to lumbar disc herniation management. As with many new advances in surgery, the risk profile these contemporary has yet be well defined. We present case a 32-year-old man who presented decreasing exercise tolerance over 6-month period after microendoscopic discectomy and lamino-foraminotomy. Subsequent work-up revealed large fistula between his right common iliac artery inferior vena cava, resulting...
Hypertonic saline causes a transient elevation of blood osmolality and has been shown to alter cellular inflammatory responses in pro-inflammatory states. Intravascular administration iodine contrast media also osmolarity.To investigate the effect on leukocyte-endothelial interaction vivo using intravital microscopy.Male Sprague-Dawley rats (n=36) were randomized into six groups treated with: saline, high osmolar medium, low endotoxin alone combination with media. The post-mesenteric venules...