A5074568879- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Crystallography and molecular interactions
- Molecular spectroscopy and chirality
- Liquid Crystal Research Advancements
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Free Radicals and Antioxidants
- Photochemistry and Electron Transfer Studies
- Photochromic and Fluorescence Chemistry
- Synthesis of heterocyclic compounds
- Electrochemical Analysis and Applications
- Chemical Reaction Mechanisms
- Electrochemical sensors and biosensors
- Synthesis and Properties of Aromatic Compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Crystal structures of chemical compounds
- Synthesis and Reactions of Organic Compounds
- Inorganic Fluorides and Related Compounds
- Multicomponent Synthesis of Heterocycles
- Nonlinear Optical Materials Research
- Chemical Synthesis and Analysis
University of Belgrade
2015-2024
Institut za filozofiju
2019
Institute of Metallurgy
2016
Fluorination of compounds causes an increase in the proton-donating ability and a decrease proton-accepting capacity groups their vicinity. The formation F···F interactions is followed by shift electron density area contact, which creates new region with larger surface area, higher negative potential, and, hence, more pronounced accepting ability. also has greater to form multiple (simultaneous) species from environment, thus compensating for reduction This phenomenon explains not only...
We present an approach for the prediction of liquid crystallinity five-ring bent-core molecules. Reported classifiers can be also used estimation influence structural modifications on LC phase formation and its stability.
Succinimides, which contain a pharmacophore responsible for anticonvulsant activity, are frequently used antiepileptic drugs and the synthesis of their new derivatives with improved efficacy tolerability presents an important task. Nowadays, multitarget/tasking methodologies focused on quantitative-structure activity relationships (mt-QSAR/mtk-QSAR) have role in rational design since they enable simultaneous prediction several standard measures biological activities at diverse experimental...
The crystal packing of two spirohydantoins was analyzed through the contribution dimeric motifs and different interactions. cooperative effect rationalized in terms formation a new region, as result F⋯F interaction.
Considering the pharmaceutical importance of hydantoins, a set 25 derivatives phenytoin, nirvanol and 5-methyl-5-phenylhydantoin, lipophilicities which were gradually increased by introduction different alkyl, cycloalkyl alkenyl groups in position N3, was synthesized. Their properties under consideration either estimated empirically, UV/Vis spectroscopy, or calculated using established medicinal chemistry software. The UV absorption spectra investigated compounds recorded region from 200 to...
We present the synthesis and characterization of ten asymmetric bent-core liquid crystals with enantiotropic modulated smectic (B<sub>7</sub> type) phases. Their relatively low wide photosensitive mesomorphic temperature range offers potential applications.
In order to get a better insight into the relationship between molecular structure and photovoltaic performance, six monoazo dye molecules containing benzoic cinnamic acid moieties were synthesized their properties studied. Three of them have not been previously used in solar cells. Spectroscopic measurements investigated compounds coupled with theoretical calculations performed. Short-circuit current density, open-circuit voltage, fill-factor determined. It was found that larger amount...
A series of novel Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with oxaprozin (Hoxa), a non-steroidal anti-inflammatory drug, has been synthesized. The drug have characterized by elemental thermogravimetric (TG) analysis, Fourier transform (FT)-IR, 1H-NMR, 13C-NMR, UV-Vis spectroscopy magnetic susceptibility measurements. (pseudo)octahedral geometry proposed for all based on electronic spectra moments. With exception the complex, where bridging bidentate mode COO groups found, FT-IR...
Accurate prediction of transition temperature is very helpful for the design new liquid crystals (LCs) because even small changes in structure can dramatically alter temperature, and therefore synthesis LCs should not be governed only by chemical intuition. A quantitative structure–property relationship (QSPR) study was performed on 243 five-ring bent-core order to predict their clearing temperatures using molecular descriptors. Decision tree multivariate adaptive regression splines (MARS),...
A series of cycloalkane-5-spirohydantoins bearing a halogeno substituted benzyl group (X = Cl and Br) in position 3 has been synthesized their structures (1–6) have determined by single crystal X-ray diffraction method. These compounds multiple functional groups, which allow greater competition and/or cooperation among the different intermolecular interactions formation structures. The molecules are linked together paired N–H⋯O hydrogen bonds R22(8) rings, while C–H⋯O lead to further...
A series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature. Their antiproliferative against HCT-116 human colon carcinoma cells were evaluated to determine structure-activity relationships. Almost all compounds exhibited statistically significant effects at a concentration 100 ?M, while derivative bearing benzyl group active even lower concentrations. Moreover, their vitro antibacterial...
A series of six novel 2-(5-arylidene-2,4-dioxotetrahydrothiazole-3-yl)propanoic acids and corresponding methyl esters were synthesized. All compounds characterized by melting points, elemental analysis, FT-IR, 1H 13C NMR spectroscopy. Crystal structure methyl-2-(5-(4-methoxybenzylidene)-2,4--dioxotetrahydrothiazole-3-yl)propionate was confirmed X-ray analysis. The antiproliferative activity all synthesized against human colon cancer, breast cancer myelogenous leukemia cell lines, i.e....
The anodic behaviour of carbamazepine (CBZ), an anticonvulsant drug, has been studied on gold electrode in 0.1 mol dm-3 phosphate buffer pH 7.0 by using cyclic voltammetry. It found that the value oxidative current pure CBZ at +0.90 V is a linear function concentration range from 1.0?10-7 to 1.0?10?4 dm?3. detection 1.0?10-8 among lowest have reported for this drug voltammetric techniques. as content tablet Galepsine? quantitatively determined. also demonstrated modification with bovine...
Antioxidant effects of twelve 3-substituted-5,5-diphenylhydantoins in concentrations 0.01, 0.1, 1, 10, and 100 µM on human colon cancer cell line HCT-116 were determined 24 h after treatment. The superoxide anion radical (O_{2}^{.}^{-}), nitrites (NO_{2}^{-}), total glutathione spectrophotometrically. Results indicated that treatment with all compounds induced a decrease O_{2}^{.}^{-} an increase NO_{2}^- cells. Treatment resulted glutathione, this indicates changes redox homeostasis. Based...