A5025133313- Synthesis and biological activity
- Immune Response and Inflammation
- Synthesis and Characterization of Heterocyclic Compounds
- Crystallization and Solubility Studies
- Bryophyte Studies and Records
- X-ray Diffraction in Crystallography
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Lichen and fungal ecology
- Parathyroid Disorders and Treatments
- Phytochemicals and Antioxidant Activities
- Nerve injury and regeneration
- Hydrogels: synthesis, properties, applications
- Bone health and osteoporosis research
- Fungal Biology and Applications
- Computational Drug Discovery Methods
- Vitamin D Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Free Radicals and Antioxidants
- T-cell and B-cell Immunology
- Nutrition and Health in Aging
- Gut microbiota and health
- Cardiovascular Function and Risk Factors
- Pain Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
University of Belgrade
2016-2025
Military Medical Academy
2011-2024
Institute of Public Health of Vojvodina
2023
Czech Academy of Sciences, Institute of Physiology
2019-2020
Zemun Hospital
2010
The role of cytokines in pathogenesis periapical lesions is not well understood. aim this study was to the correlation between proinflammatory and immunoregulatory their relationship with cellular composition clinical presentation.Inflammatory cells were isolated from 67 human cultivated for 24 h. levels cytokines: interleukin-1 beta (IL-1beta), IL-6, IL-8 tumour necrosis factor alpha (TNF-alpha) transforming growth factor-beta (TGF-beta) IL-10 determined culture supernatants using a...
Introduction. Brain detrimental effects are under-recognised complication of chronic heart failure (CHF). One the major causes may be cerebral hypoperfusion. This study was designed to investigate relationship between blood flow (CBF) and severity CHF as well evaluate its determinants among different parameters cardiac dysfunction.Methods. Seventy-one males with NYHA class II III 20 control subjects age ≥ 55 years were recruited. CBF evaluated by colour duplex sonography extracranial...
Peripheral nerve injury (PNI) leads to a series of cellular and molecular events necessary for axon regeneration reinnervation target tissues, among which inflammation is crucial the orchestration all these processes. Macrophage activation underlies pathogenesis PNI characterized by morphological/phenotype transformation from proinflammatory (M1) an anti-inflammatory (M2) type with different functions in inflammatory reparative process. The aim this study was evaluate influence vitamin B...
Numerous representatives of mosses, including Hypnum cupressiforme, have been used to alleviate different inflammation-related conditions. However, the mode action underlying this anti-inflammatory potential has poorly understood. Moreover, influence seasonality on chemical composition and biological activity mosses is generally overlooked. This study aimed investigate seasonal changes (spring, summer, autumn) secondary metabolite activities ethyl acetate H. cupressiforme extracts....
Peripheral nerve injury (PNI) triggers a complex multi-cellular response involving the injured neurons, Schwann cells (SCs), and immune cells, often resulting in poor functional recovery. The aim of this study was to investigate effects treatment with vitamin B (B1, B2, B3, B5, B6, B12) on interaction between macrophages SCs during recovery period after PNI. Transection motor branch femoral followed by reconstruction termino-terminal anastomosis used as an experimental model. Isolated nerves...
Recently, there has been an increasing interest in the chemistry and biological potential of mosses, since a large number biologically active compounds have found within these species. This study aimed at examining chemical composition immunomodulatory (antioxidant, antidiabetic, anti-neuroinflammatory/antineurodegenerative, antitumor activities) moss
Bioactive compounds from natural sources are of great importance because their potential pharmacological activity and tremendous structural diversity. In this study, the chemical composition different moss extracts Hedwigia ciliata P. Beauv. have been examined, as well antioxidant, antineurodegenerative/anti-neuroinflammatory, antidiabetic, antiproliferative potential. The were prepared by Soxhlet extractor using solvents polarity. Chemical characterization revealed presence phenolics...
This study was designed to evaluate the genoprotective, antigenotoxic, as well antitumor potential of methanolic, ethanolic, and aqueous extracts Melissa officinalis, Mentha × piperita, Ocimum basilicum, Rosmarinus Salvia Satureja montana (Lamiaceae), in different model systems. The polyphenols these were quantified both spectrophotometrically using HPLC-DAD technique, while DPPH assay used assess antioxidant activity. genoprotective tested on pUC19 Escherichia coli XL1-blue,...
The present study aimed to investigate the neuroprotective effects of vitamin B complex (B1, B2, B3, B5, B6, and B12-VBC), by studying changes in femoral nerve, quadriceps muscle, popliteal lymph nodes gut microbiota rat model multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). VBC treatment attenuated clinical signs EAE during disease, reduced duration thereby contributing a faster recovery. In VBC-treated rats, significant decrease nerve muscle nuclear density was revealed...
Global cerebral blood flow (CBF), as a measure of perfusion, can be non-invasively studied using Doppler sonography. Chronic heart failure (CHF) increases the risk stroke and dementia. One possible causes may hypoperfusion in CHF patients. Therefore, we aimed to investigate relationship between CBF severity. The study was performed 76 ischemic or idiopathic dilatative cardiomyopathy patients, left ventricular ejection fraction (LVEF) < 40%, with no clinical evidence decompensation 20 healthy...
3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC50=6.7±0.8 μM) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos LINDLEY, obtained hydrodistillation and spectrometricaly identified unambiguously.