A5008046748- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Multi-Criteria Decision Making
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Fuzzy and Soft Set Theory
- Glycosylation and Glycoproteins Research
- Drug Transport and Resistance Mechanisms
- Rings, Modules, and Algebras
- Liver Disease Diagnosis and Treatment
- Advanced Algebra and Logic
- Fuzzy Systems and Optimization
- Research studies in Vietnam
- Carbohydrate Chemistry and Synthesis
- Injury Epidemiology and Prevention
- Per- and polyfluoroalkyl substances research
- Epigenetics and DNA Methylation
- Adrenal and Paraganglionic Tumors
- Medical Imaging Techniques and Applications
- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Galectins and Cancer Biology
- Cancer Genomics and Diagnostics
- Burn Injury Management and Outcomes
University of Illinois Urbana-Champaign
2015-2025
Johns Hopkins Hospital
2025
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
Abdul Wali Khan University Mardan
2023-2024
Dow University of Health Sciences
2024
Punjab Medical College
2020-2021
University of Education
2019
University of Toledo
2011
Although major genetic networks controlling early liver specification and morphogenesis are known, the mechanisms responsible for postnatal hepatic maturation poorly understood. Here we employ global analyses of mouse transcriptome to demonstrate that remodelling is accompanied by large-scale transcriptional post-transcriptional transitions cell-type-specific temporally coordinated. Combining detailed expression with gain- loss-of-function studies, identify epithelial splicing regulatory...
Abstract Regulation of RNA processing contributes profoundly to tissue development and physiology. Here, we report that serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte function survival. Although SRSF1 mainly known its many roles in mRNA metabolism, it also crucial maintaining genome stability. We show acute liver damage the setting targeted deletion mice associated with excessive formation deleterious RNA–DNA hybrids (R-loops), which induce DNA damage. Combining...
Hepatocyte polyploidy and maturity are critical to acquiring specialized liver functions. Multiple intracellular extracellular factors influence ploidy, but how they cooperate temporally steer polyploidization maturation or post-transcriptional mechanisms integrate into these paradigms is unknown. Here, we identified an important regulatory hierarchy in which postnatal activation of epithelial splicing protein 2 (ESRP2) stimulates processing liver-specific microRNA ( miR-122 ) facilitate...
Abstract Fibrolamellar carcinoma (FLC) is a rare and aggressive malignancy of the liver that predominantly affects adolescents young adults. These tumors are distinct from conventional hepatocellular carcinomas characterized histologically by thick fibrous collagen bands. The transcriptome FLC recurrent oncogenic fusion between DNAJB1 PRKACA. Liver resection potentially curative treatment option for early-stage FLC, but there no standard systemic therapies available advanced FLC. Most...
Binding of the thiazolidinedione antidiabetic drug pioglitazone led to discovery a novel outer mitochondrial membrane protein unknown function called mitoNEET. The is homodimeric and contains uniquely ligated two iron–two sulfur cluster in each its cytosolic domains. Electrospray ionization mass spectrometry was employed characterize solutions soluble domain (amino acids 32–108) protein. Ions characteristic dimers containing cofactors were readily detected under native conditions. mitoNEET...
Cellular quiescence and cell cycle reentry regulate vital biological processes such as cellular development tissue homeostasis are controlled by precise regulation of gene expression. The roles long noncoding RNAs (lncRNAs) during these remain to be elucidated. By performing genome-wide transcriptome analyses, we identify differential expression several hundreds lncRNAs, including a significant number the less-characterized class microRNA-host-gene ( MIRHG ) lncRNAs or lnc- MIRHGs , in human...
Liver diseases are caused by many factors, such as genetics, nutrition, and viruses. Therefore, it is important to delineate transcriptomic changes that occur in various liver diseases.We performed high-throughput sequencing of mouse livers with diverse types injuries, including cholestasis, diet-induced steatosis, partial hepatectomy. Comparative analysis transcriptome from mice human samples viral infections (HBV HCV), alcoholic hepatitis (AH), non-alcoholic steatohepatitis (NASH), biliary...
Abstract In the present study, we perform an association analysis focusing on expression changes of 1344 RNA Binding proteins (RBPs) as a function age and gender in human liver. We identify 88 45 RBPs to be significantly associated with respectively. Experimental verification several predicted associations mice confirmed our findings. Our results suggest that small fraction gender-associated (~40%) are expressed higher males than females. Altogether, these observations show important...
Loss of two hepatic nuclear receptors muddles the Golgi and sugarcoat on proteins.
Previous studies have linked persistent elevations in growth hormone (GH) and insulin-like factor-1 (IGF-1) to cardiac abnormalities including aortic root dilation. Guidelines the management of this dilation below size recommended for surgery not been well defined but follow-up intervention when appropriate could be life-saving. We report case a man his 60s who had living with undiagnosed acromegaly many years. His initial assessment through point-of-care ultrasound raised concerns about...
SUMMARY Hepatocyte polyploidy and maturity are critical to acquiring specialized liver functions. Multiple intra- extracellular factors influence ploidy, but how they cooperate temporally steer polyploidization maturation or post-transcriptional mechanisms integrate into these paradigms is unknown. Here, we identified an important regulatory hierarchy in which postnatal activation of Epithelial-Splicing-Regulatory-Protein-2 (ESRP2) stimulates biogenesis liver-specific microRNA (miR-122),...
In this manuscript, we develop TOPSIS (Technique for order of preference by similarity to ideal solution) method in the setting bipolar fuzzy environment which has ability deal data while keeping view positive and negative aspects. By using sets, establish novel concept rating numerous preferences any object described through connection number(CN) set pair analysis(SPA). regard, extend based on analysis(SPA) frame sets. For sake verification, effectiveness superiority our method, conduct...
Connectivity in graphs is useful describing different types of communication systems like neural networks, computer etc. In the design any network, it essential to evaluate connections based on their strengths. this manuscript, we comprehensively describe various connectivity parameters related interval-valued intuitionistic fuzzy (IVIFGs). These are generalizations defined for graphs, and graphs. First, introduce bridges (IVIF bridges) cut-nodes cut-nodes). We discuss many characteristics...
We introduce and discuss the weakly prime primary ideals of a gammaseminearrings with illustrative examples. also present few characterizations these ideals.
Background: The prevalence of Multi-Drug Resistance-Tuberculosis (MDR-TB) among retreatment cases is very high. It has become a serious public health issue in Pakistan and can affect greatly TB control strategies. So, we conducted the present research work to update systematic review literature available on MDR-TB cases. Objective: To analyze resistance pattern multidrug-resistant tuberculosis. study new cases, Study Design: Cross-sectional study. Settings: Pathology department, Allied...
Background: Despite a lot of research regarding postgraduate residents (PGRs) duty hours, its benefits are still controversial. There is constant need for further evaluation. So, we conducted the present work to update systematic review literature on hour restrictions. Objective: To evaluate effects 80-hour trainees per week, restrictions patient safety, resident well-being, and education. Study Design: Cross-Sectional Survey. Settings: Allied Hospital, Faisalabad Pakistan. Duration: One...