A5080646928- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Prenatal Screening and Diagnostics
- Blood groups and transfusion
- Renal cell carcinoma treatment
- Maternal and fetal healthcare
- Renal and related cancers
- Erythrocyte Function and Pathophysiology
- Genomics and Rare Diseases
- RNA Research and Splicing
- Pregnancy-related medical research
- Pregnancy and preeclampsia studies
- Neurogenetic and Muscular Disorders Research
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Maternal and Perinatal Health Interventions
- Obstructive Sleep Apnea Research
- Luminescence Properties of Advanced Materials
- Molecular Biology Techniques and Applications
- Pediatric Urology and Nephrology Studies
- Multiple and Secondary Primary Cancers
- Thyroid Disorders and Treatments
- Bacteriophages and microbial interactions
- Genetics and Neurodevelopmental Disorders
- Nanoplatforms for cancer theranostics
Dongguan People’s Hospital
2014-2024
Peking University People's Hospital
2024
Peking University
2024
Hebei University of Technology
2016-2023
Southern Medical University
2010-2022
Guangzhou Medical University
2020-2021
Third Affiliated Hospital of Guangzhou Medical University
2020-2021
ORCID
2020
Zero to Three
2010
Although maternal deaths are rare in developed regions, the morbidity associated with severe postpartum hemorrhage (SPPH) remains a major problem. To determine prevalence and risk factors of SPPH, we analyzed data women who gave birth Guangzhou Medical Centre for Critical Pregnant Women, which received large quantity critically ill obstetric patients were transferred from other hospitals Southern China.In this study, conducted retrospective case-control study to SPPH among cohort after 28...
Xiong F, Sun M, Zhang X, Cai R, Zhou Y, Lou J, Zeng L, Q, Xiao Shang Wei T, Chen P, Xu X. Molecular epidemiological survey of haemoglobinopathies in the Guangxi Zhuang Autonomous Region southern China. Accurate and up‐to‐date data on frequency among populations Region, where are most endemic China, required. In our study, a total 5789 samples obtained from members Han, Zhang, Yao ethnic groups six geographical areas Province were analysed systematically terms both haematological molecular...
Abstract Background The clinical syndrome of thalassemia intermedia (TI) results from the β-globin genotypes in combination with factors to produce fetal haemoglobin (HbF) and/or co-inheritance α-thalassemia. However, very little is currently known molecular basis Chinese TI patients. Methods We systematically analyzed and characterized genotypes, α-thalassemia determinants, primary genetic modifiers linked production HbF aggravation α/β imbalance 117 Genotype-phenotype correlations were...
Background: Abnormal concentrations of maternal thyroid hormones are risk factors for certain obstetrical complications. However, the influence induced by different types dysfunction on complications and outcomes remains controversial. This study aimed to systematically evaluate prevalence distinct subtypes in pregnant women their specific associations with adverse obstetric outcomes, thereby clarifying clinical management priorities. Methods: In a retrospective cohort study, total 17,219...
The present study aimed to identify the differentially expressed genes (DEGs) regulated by microRNA (miRNA)-221 and miRNA-222 that are associated with resistance of breast cancer fulvestrant. GSE19777 transcription profile was downloaded from Gene Expression Omnibus database, includes data three samples antisense miRNA-221-transfected fulvestrant-resistant MCF7-FR cells, miRNA-222-transfected cells control inhibitor (green fluorescent protein)-treated cells. linear models for microarray...
Objective: Compare the clinical severity of second preeclampsia with first preeclampsia. Methods: This retrospective longitudinal cohort study was conducted in three teaching hospitals Guangzhou, where there were a total 296 405 deliveries between 2010 and 2021. Two consecutive singleton complicated included. Clinical features, laboratory results within 1 week before delivery, maternal neonatal outcomes both collected. Univariate analyses made using paired Wilcoxon tests McNemar tests....
Abstract Background: Although maternal deaths are rare in developed regions, the morbidity associated with severe postpartum hemorrhage remains a major problem. To provide new insight into hemorrhage, we analyzed data of women giving birth Guangzhou Medical Centre for Critical Pregnant Women, which receiveda large quantity critically ill obstetric patients from other hospitals Southern China. Methods: In this study, conducted retrospective cohort by using criteria morbidities, was defined...
To present the prenatal findings and molecular cytogenetic analyses of a de novo interstitial deletion 1q23.3 encompassing PBX1 gene. A 32-year-old woman (gravida 1, para 0) underwent amniocentesis at 26 weeks' gestation because constant small fetal kidneys on ultrasound. Chromosome microarray analysis (CMA) detected 1.871 Mb 1q23.3. The encompassed 2 genes LMX1A. haploinsufficiency had been reported to lead syndromic congenital anomalies kidney urinary tract (CAKUT) in humans. Furthermore,...
During the prenatal period, number variation of chromosomes 13, 18, 21, X and Y accounts for more than 80% clinically significant chromosomal abnormalities diagnosed. Rapid tests diagnosis these can improve pregnancy management alleviate parental anxiety. Here, we present a molecular alternative method detecting common aneuploidies.This is based on co-amplification segmental duplications located two different using single pair primers. Segmental have high degree sequence identity, but...
Objectives: In clinical practice, the majority of α-thalassaemia cases arise from deletions α-globin genes. However, a subset is attributed to rare haemoglobin variants, which can manifest with borderline or normal screening results, potentially leading missed diagnoses in practice.
Abstract Introduction Patients with a homozygous β 0 ‐thalassemia mutation usually have transfusion‐dependent β‐thalassemia major phenotype. However, some patients present relatively mild and even normal phenotype always high level of Hb F induced by genetic modifiers. Methods In this study, we identified ( HBB : c.126_129delCTTT) in 36‐year‐old pregnant woman. She had not presented any clinical symptoms since birth. To investigate her unexpected phenotype, known modifiers that ameliorate...
We identified two novel δ-globin gene mutations in families during routine thalassemia screening. One missense mutation at codon 73 on the [δ73(E17)Asp→Val, HBD: c.221A>T] which results a Hb A2 variant homologous to β-globin called Mobile [β73(E17)Asp→Val, HBB: and we have named this A2-Henan. The other is nonsense [δ7(A4)Glu→Stop, c.22G>T] gives rise stop (TAG) 7, resulting δ0-thalassemia (δ0-thal). one individual with homozygous c.22G>T was absent.
The α+-thal deletion of 3.557 kb (NG_000006.1: g.32745_36301del, -αMAL3.5), involving the entire α2-globin gene, was identified in a Chinese family by multiplex ligation-dependent probe amplification (MLPA) followed gap-polymerase chain reaction (gap-PCR) and sequencing. proband, compound heterozygote for this mutant gene Southeast Asian (- -SEA; NG_000006.1: g.26264_45564del19301) deletion, had phenotype Hb H disease [hemoglobin (Hb) 7.6 g/dL, mean corpuscular volume (MCV) 60.0 fL, (β4)...
In practice, gap-polymerase chain reaction (gap-PCR) and reversed dot-blot are the two most frequently used molecular diagnostic methods for α-thalassemia (α-thal) genotyping. Here, we describe three Chinese individuals from unrelated families in whom a polymorphism on α-globin gene cluster led to pitfalls. During general diagnosis of thalassemia, with unexplained results were found. Blood or chorionic villus samples collected these their family members. Hematological investigations genetic...
To evaluate the incidence and types of chromosomal abnormalities in pregnancy loss aborted fetuses with anomaly compare performance subtelomeric MLPA microarray analysis (CMA) these specimens.Samples were collected from spontaneous miscarriages, stillbirths between January 2015 April 2019. Chromosomal detected using CMA.Among 172 miscarriage samples, CMA pathogenic 88 cases. could identified all aneuploidies most CNVs, missing polyploidies; Of 30 stillbirths, one CNV two VOUS by CMA, which...
To carry out carrier screening for Spinal muscular atrophy (SMA) in reproductive-aged individuals from Dongguan region and determine the frequency of SMN1 gene mutations.Reproductive-aged who underwent genetic at Maternal Child Health Care Hospital March 2020 to August 2022 were selected as study subjects. Deletions exon 7 8 (E7/E8) detected by real-time fluorescence quantitative PCR (qPCR), prenatal diagnosis was provided couples multiple ligation-dependent probe amplification (MLPA).Among...
Objectives: We aim to establish a predictive model for recurrent preeclampsia. Methods: A retrospective review of medical records from three hospitals between 2010 and 2021 was conducted. The study included women who had two consecutive singleton deliveries at the same hospital, with first delivery complicated by multivariable logistic regression constructed using training cohort, subsequently cross-validated tested an independent cohort. model's performance assessed in terms discrimination...