A5101807949- Advanced Radiotherapy Techniques
- Coronary Interventions and Diagnostics
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Nitric Oxide and Endothelin Effects
- Heme Oxygenase-1 and Carbon Monoxide
- Prostate Cancer Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Cerebrovascular and Carotid Artery Diseases
- Prostate Cancer Treatment and Research
- Radiation Dose and Imaging
- Neurological Disease Mechanisms and Treatments
- Wound Healing and Treatments
- Heat shock proteins research
- Advanced X-ray and CT Imaging
- Dermatologic Treatments and Research
- Aortic aneurysm repair treatments
- Mesenchymal stem cell research
- Traumatic Brain Injury and Neurovascular Disturbances
- High Altitude and Hypoxia
- Soil Carbon and Nitrogen Dynamics
- Intracerebral and Subarachnoid Hemorrhage Research
Second Affiliated Hospital of Zhejiang University
2022-2025
South China University of Technology
2023-2025
Hangzhou First People's Hospital
2010-2025
Westlake University
2025
Jilin Agricultural University
2025
Chinese PLA General Hospital
2025
Guilin University of Technology
2022-2024
Shaanxi University of Chinese Medicine
2012-2024
Nankai University
2024
Huaihua University
2022-2024
Increased fructose consumption predisposes the liver to nonalcoholic fatty disease (NAFLD), but mechanisms are elusive. Thioredoxin-interacting protein (TXNIP) links oxidative stress NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation and this signaling axis may be involved in fructose-induced NAFLD. Here, we explore role of reactive oxygen species (ROS)-induced TXNIP overexpression fructose-mediated hepatic NLRP3 activation, inflammation, lipid...
Although maternal deaths are rare in developed regions, the morbidity associated with severe postpartum hemorrhage (SPPH) remains a major problem. To determine prevalence and risk factors of SPPH, we analyzed data women who gave birth Guangzhou Medical Centre for Critical Pregnant Women, which received large quantity critically ill obstetric patients were transferred from other hospitals Southern China.In this study, conducted retrospective case-control study to SPPH among cohort after 28...
Background —Altered vascular mechanics resulting from changes in collagen and integrins may influence resistance artery structure function and, therefore, peripheral blood pressure spontaneously hypertensive rats (SHR). Methods Results —Effects of age, angiotensin-converting enzyme inhibition (fosinopril, 10 to 30 mg/kg per day), AT 1 -receptor antagonism (irbesartan, 50 day) on structure, mechanics, composition were assessed SHR. Systolic was elevated young SHR (130±2 mm Hg) compared with...
Objective: To determine the clinically observed incidence and severity of acute skin toxicity with breast intensity modulated radiation therapy (IMRT), compare results a matched cohort patients treated by conventional therapy. Our hypothesis is that measures to decrease dose inhomogeneity within IMRT will improve toxicity. Materials Methods: The study population consists 73 women early stage cancer breast-conserving surgery IMRT. technique involves an iteration method for optimization...
The Monte Carlo method enables accurate dose calculation for radiation therapy treatment planning and has been implemented in some commercial systems. Unlike conventional algorithms that provide patient information terms of to water with variable electron density, the calculates energy deposition different media expresses a medium. This paper discusses differences calculated using densities biological clinical issues on specification including prescription plan evaluation We will demonstrate...
Photon beams of 4, 6 and 15 MV from Varian Clinac 2100C 2300C/D accelerators were simulated using the EGS4/BEAM code system. The modelled as a combination component modules (CMs) consisting target, primary collimator, exit window, flattening filter, monitor chamber, secondary ring photon jaws protection window. A full phase space file was scored directly above upper analysed beam data processing software, BEAMDP, to derive characteristics, such planar fluence, angular distribution, energy...
Increasing the dose rate offers time saving for IMRT delivery but dosimetric accuracy is a concern, especially in case of treating moving target. The objective this work to determine effect associated with organ motion and gated treatment using step‐and‐shoot delivery. Both measurements analytical simulation on clinical plans are performed study differences between high low Various sites liver, lung, pancreas, breast cancers were delivered custom‐made motorized phantom, which simulated...
Rationale: Idiopathic pulmonary fibrosis (IPF) is an irreversible, fatal interstitial lung disease lacking specific therapeutics.Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of nicotinamide adenine dinucleotide (NAD) salvage biosynthesis pathway and a cytokine, has been previously reported as biomarker for diseases; however, role NAMPT in not elucidated.Methods: We identified level changes by analyzing public RNA-Seq databases, verified collected clinical samples...
We have investigated the tongue-and-groove effect on IMRT dose distributions for a Varian MLC. compared calculated using intensity maps with and without effect. Our results showed that, one intensity-modulated treatment field, maximum could be up to 10% of in distributions. For an multiple gantry angles (⩾5), difference between was hardly visible, less than 1.6% two typical clinical cases studied. After considering patient setup errors, were smoothed reduced insignificant differences plans...
This paper investigates the clinical significance of real-time monitoring intrafractional prostate motion during external beam radiotherapy using a commercial 4D localization system. Intrafractional was tracked 8,660 treatment fractions for 236 patients. The following statistics were analyzed: 1) percentage in which shifted 2-7 mm certain duration; 2) proportion entire tracking time 2-7mm; and 3) each minute shift exceeded mm. ten patients exhibiting maximum intrafractional-motion patterns...
Dose calculation plays an important role in the accuracy of radiotherapy treatment planning and beam delivery. The Monte Carlo (MC) method is capable achieving highest dose has been implemented many commercial systems for planning. objective this task group was to assist clinical physicists with potentially complex acceptance testing commissioning MC‐based (TPS) photon electron calculations. This report provides overview on general approach implementation TPS a specific focus models beams....
Morinda officinalis oligosaccharides have been reported to exert neuroprotective and antidepressant-like effects in the forced swim test mice. However, mechanisms that underlie of are unclear. Chronic unpredictable stress were used explore resilience rats. The phosphoinositide-3 kinase inhibitor LY294002 was microinjected medial prefrontal cortex role glycogen synthase kinase-3β oligosaccharides. expression brain-derived neurotrophic factor, phosphorylated-Ser9-glycogen 3β, β-catenin,...
Abstract Background Breast cancer (BC) is a common in women worldwide. Emerging evidence has indicated that circular RNA hsa‐circ_0007255 (circ_0007255) prognostic mediator BC progression. However, the functional role of circ_0007255 needs to be determined. Methods The expression circ_0007255, microRNA (miR)‐335‐5p, and SIX Homeobox 2 (SIX2) was evaluated using quantitative real‐time polymerase chain reaction (qRT‐PCR) or western blot assay. Actinomycin D RNase R treatment performed analyze...
Abstract —In vitro experiments suggest that angiotensin II (Ang II) may cause growth via type 1 (AT ) receptors and apoptosis 2 receptors. To answer the question of whether AT or receptor activation could induce in vasculature vivo, Wistar rats were infused for 7 days with Ang (120 ng · kg −1 min subcutaneously) treated antagonist PD 123319 (30 mg d losartan (10 orally). Apoptosis thoracic aorta was quantified by radiolabeled DNA laddering terminal deoxynucleotide transferase–mediated dUTP...
Endothelin (ET)-1 is a potent vasoconstrictor peptide which also endowed with hypertrophic and mitogenic properties. Enhanced ET-1 gene expression in blood vessels of rats hypertension induced by deoxycorticosterone acetate (DOCA)-salt has been previously demonstrated. The objective this study was: (1) to investigate the individual effects salt DOCA, development DOCA-salt-hypertensive rats, on vessels; (2) correlate presence enhanced ET severity vascular hypertrophy. By providing and/ or...
1. Impaired endothelium-dependent relaxation has been previously demonstrated in blood vessels of hypertensive rats and humans with essential hypertension. Arteries from spontaneously have shown to produce, response high concentrations acetylcholine, a vasoconstrictor substance called endothelium-derived contracting factor, the production which can be inhibited by indomethacin or other cyclo-oxygenase inhibitors, suggesting that it is prostanoid. The mechanisms involved human arteries are...
Conventional IMRT dose verification using film and ion chamber measurements is useful but limited with respect to the actual distribution received by patient. The Monte Carlo simulation has been introduced as an independent tool for patient CT data MLC leaf sequence files, which validates calculation accuracy not plan delivery accuracy. In this work, we propose a based method that reconstructs CT, beam on information from record verify system (R/V), log files obtained during positions MUs...