A5010709017- Cardiac Valve Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Transplantation: Methods and Outcomes
- Meta-analysis and systematic reviews
- Cardiac pacing and defibrillation studies
- Liver Disease and Transplantation
- Electrolyte and hormonal disorders
- Reproductive Health and Technologies
- Sperm and Testicular Function
- Ethics in Clinical Research
- Aortic aneurysm repair treatments
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Autoimmune and Inflammatory Disorders Research
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Clinical practice guidelines implementation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Reliability and Agreement in Measurement
- Assisted Reproductive Technology and Twin Pregnancy
- Lubricants and Their Additives
- Sphingolipid Metabolism and Signaling
- Vascular Procedures and Complications
- Cardiac tumors and thrombi
- PI3K/AKT/mTOR signaling in cancer
Second Affiliated Hospital of Zhejiang University
2022-2025
Zhejiang University
2024
Lanzhou University
2013-2023
First Hospital of Lanzhou University
2015-2023
First Automotive Works (China)
2021
Rationale: Idiopathic pulmonary fibrosis (IPF) is an irreversible, fatal interstitial lung disease lacking specific therapeutics.Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of nicotinamide adenine dinucleotide (NAD) salvage biosynthesis pathway and a cytokine, has been previously reported as biomarker for diseases; however, role NAMPT in not elucidated.Methods: We identified level changes by analyzing public RNA-Seq databases, verified collected clinical samples...
ABSTRACT Lung ischemia–reperfusion injury (LIRI) is a critical pathological process associated with various clinical conditions, characterised by excessive inflammatory responses and cell death, which can lead to severe respiratory dysfunction even mortality. However, no effective therapeutic strategy currently available. This study investigates the protective effects underlying mechanisms of Hsp90 inhibitor 17‐dimethylaminoethylamino (17‐DMAG) in LIRI. An vivo mouse model LIRI was...
Lung ischemia-reperfusion injury (LIRI) is associated with many diseases, including primary graft dysfunction after lung transplantation, and has no specific effective therapies. Necroptosis contributes to the pathogenesis of injury. Necrostatin-1 (Nec-1), necroptosis inhibitor targeting RIPK1, been reported alleviate in various organs. However, underlying mechanism Nec-1 LIRI remains unclear. In this paper, an vivo model was built up by left hilar clamping mice, vitro cold (CI/R) using...
Background Esophageal cancer (ESCA) is a form of malignant tumor associated with chronic inflammation and immune dysregulation. However, the specific status key mechanisms regulation in this disease require further exploration. Methods To investigate features human ESCA microenvironment its possible regulation, we performed mass cytometry by time flight, single-cell RNA sequencing, multicolor fluorescence staining tissue, flow analyses on paracancerous tissue from treatment-naïve patients....
The tribological performance of the piston ring–cylinder liner pair is affected by multiple factors. In this study, orthogonal test method used to comprehensively explore influence oil dilution, cylinder surface coating, and working conditions on friction wear pair. results show that a certain degree dilution beneficial performance, so further investigated using control variable method. depth decreases first then increases with increase dilution. Combined scanning electron microscope energy...
Abstract Objective: The aim of this study was to determine the diagnostic accuracy different computer-aided (CAD) systems for thyroid nodules classification. Methods: A systematic search literature conducted from inception until March, 2019 using PubMed, EMBASE, Web science, and Cochrane library. Literature selection data extraction were by 2 independent reviewers. Numerical values sensitivity specificity obtained false negative (FN), positive (FP), true (TN), (TP) rates, presented alongside...
To enhance the operability of rat orthotopic left lung transplantation model, we implemented several improvements and meticulously detailed procedure. One hundred thirty-one healthy male Sprague Dawley rats, weighing between 250 300 g, were utilized, with 64 serving as donors, recipients, 3 sham controls. We employed a modified three-cuff technique for transplantation. Notably, our perfusion method could prevent donor edema, while waist-shaped cuffs minimized suture slippage during...
Abstract Background: Multiple sclerosis is the most common demyelinating disease of central nervous system with serious social and economic burden. Siponimod a sphingosine-1-phosphate receptor agonist, clinical trials in past decade have shown good prospects for treatment multiple sclerosis. But there lack comprehensive understanding dose–effect relationship safety different subtypes at present. Methods: We will perform systematic review meta-analysis randomized controlled to evaluate...
Postoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery, and randomised clinical trials (RCTs) systematic reviews have been conducted to compare evaluate different pharmacological interventions for preventing POAF. This study aimed explore effect of prophylaxis against POAF after surgery using network meta-analysis (NMA).
Abstract Background: Prostate cancer (PCa) is one of the most common primary malignancies in humans and second leading cause cancer-specific mortality among Western males. Computer-aided detection (CAD) systems have been developed for accurate automated PCa diagnosis, but diagnostic accuracy different CAD based on magnetic resonance imaging (MRI) remains controversial. The aim this study to systematically review published evidence investigate MRI PCa. Methods: We will conduct systematic...
Abstract Rationale: Pulmonary artery sarcomas (PAS) are easily misdiagnosed as thromboembolic disease of pulmonary arteries, because rarity and presenting with nonspecific signs, symptoms, or imaging findings. Patient concerns: A 26-year-old man was admitted to the department invasive technology fever dyspnea. Blood tests showed inflammatory activity, a slight increase D-dimer Fibrin Degradation Product. chest enhanced computed tomography (CT) scanning revealed multiple filling defects...
Transcatheter aortic valve replacement (TAVR) has become an essential alternate option for people suffering from stenosis. However, the efficacy and safety of TAVR elderly population (aged over 80 years) is still unclear.We plan to perform a systematic review meta-analysis clinical controlled trials propensity-match cohort studies evaluate short- long-term outcomes in stenosis patients who undergo transcatheter or surgical replacement. We will search PubMed, EMBASE, Cochrane Library using...
Background There has been an increasing interest in cluster randomised controlled trial (CRT) over the past 20 years. Little is known about how many CRTs were used by clinical practice guidelines. Methods We searched National Guideline Clearinghouse (NGC) which a public resource for evidence-based guidelines on December 31, 2012. selected provide MEDLINE full-text linking and then we checked all references cited those Results included 564 they contained 57495 references. identified 13 17...
Background There has been an increasing interest in systematic reviews of traditional Chinese medicine (SR-TCM) over the past 10 years. Little is known about quality evidence SR-TCM. Methods GRADE (Grading Recommendations Assessment, Development and Evaluation) system a tool to rate SRs other body. We searched CBM (China Biomedicine Database) from 1978 2012 included all SR-TCM field cancer treatment. used assess those SRs. Two reviewers independently screened titles abstracts identified...