A5039213422- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Hepatitis B Virus Studies
- Global Cancer Incidence and Screening
- Cancer Treatment and Pharmacology
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- COVID-19 and healthcare impacts
- Respiratory viral infections research
- Lung Cancer Treatments and Mutations
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- Cancer-related molecular mechanisms research
- Infectious Encephalopathies and Encephalitis
- PARP inhibition in cancer therapy
- Gestational Trophoblastic Disease Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced biosensing and bioanalysis techniques
- Cancer Genomics and Diagnostics
Ain Shams University
2014-2024
Ain Shams University Hospital
2020
Cairo University
2002-2018
Cairo University hospitals
2015
Abstract Favipiravir is considered a potential treatment for COVID-19 due its efficacy against different viral infections. We aimed to explore the safety and of favipiravir in mild moderate cases. It was randomized-controlled open-label interventional phase 3 clinical trial [NCT04349241]. 100 patients were recruited from 18th April till May. 50 received 3200 mg at day 1 followed by 600 twice (day 2–day 10). hydroxychloroquine 800 200 2–10) oral oseltamivir 75 mg/12 h/day 10 days. Patients...
Treatment of extensive diffuse pigmented villonodular synovitis (PVNS) large joints by isolated surgical resection is unsatisfactory, with high rates local recurrence. Post-synovectomy adjuvant treatment external beam radiation therapy or intra-articular injection radioactive material as yttrium-90 ( 90 Y) yielded better results. Between January 2005 and 2007, 12 patients (eight men four women aged 19–49 years) PVNS the knee were treated. All had an post-operative (2,600–3,000 cGy)...
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection provides a critical host-immunological challenge. Aim: We explore the effect of host-genetic variation in interferon-lambda-3 rs12979860, Tolloid Like–1 (TLL1) rs17047200 and Discoidin domain receptor 1(DDR1) rs4618569 on host response to viral infections disease severity that may probe mechanistic approach allelic virus-induced inflammatory responses. Methods: 141 COVID-19 positive patients 100 healthy...
Background. Hepatitis C virus (HCV) is an underappreciated cause of pediatric liver disease, most frequently acquired by vertical transmission (VT). Current guidelines that include the option screening infants for HCV RNA at 1-2 months are based on data prior to current real-time polymerase chain reaction (PCR)-based testing. Previous studies have demonstrated VT rates 4%-15% and association with high maternal viral load. We evaluated in assessed risk factors a prospective cohort Cairo,...
Postpartum hepatitis C viral (HCV) load decline followed by spontaneous clearance has been previously described. Herein we identify predictors for in a cohort of HCV-infected postpartum women. Pregnant women at Cairo University were screened anti-HCV antibodies and HCV RNA, viremic tested quantitative RNA 3, 6, 9, 12 months postpartum. Spontaneous was defined as undetectable viremia twice least 6-months apart. Associations between demographic, obstetrical, risk factors, interleukin-28B gene...
Introduction: The incidence of liver cancer is one the highest in world. HCC represents up to 90% all malignancies. In Egypt, constitutes a significant public health problem. Where it responsible for 33.63% and 13.54% cancers males females respectively. Hepatocellular carcinoma occurs number preexisting conditions that commonly includes hepatitis C B, alcoholic nonalcoholic cirrhosis. It has poor prognosis after discovery, which usually at late stage disease. This had been strongly linked...
Acute coronary syndrome (ACS) is a major cause of death all over the world. STEMI represents type myocardial infarction with acute ST elevation. We aimed to assess predictive power potential RNA panel expression in syndrome.We used silico data analysis retrieve RNAs related glycerophospholipid metabolism dysregulation and specific ACS that results selection Alpha/Beta hydrolase fold domain4 (ABHD4) mRNA its epigenetic regulators (Foxf1 adjacent noncoding developmental regulatory (FENDRR)...
(1) Background: The coronavirus (COVID-19) pandemic is still a major global health problem, despite the development of several vaccines and diagnostic assays. Moreover, broad symptoms, from none to severe pneumonia, various responses assays, make infection control challenging. Therefore, there an urgent need develop non-invasive biomarkers quickly determine severity. Circulating RNAs have been proven be potential for variety diseases, including infectious ones. This study aimed genetic...
Abstract In low‐middle income countries (LMICs) and the Middle East North Africa (MENA) region, there is an unmet need to establish improve breast cancer (BC) awareness, early diagnosis risk reduction programs. During 12th Breast, Gynecological & Immuno‐oncology International Cancer Conference ‐ Egypt 2020, 26 experts from 7 worldwide voted first consensus for BC detection in LMICs/MENA region. The panel advised that extreme necessity a well‐developed data registries prospective clinical...
To assess the diagnostic effectiveness of unenhanced-multiparametric magnetic resonance imaging (mp MRI) as an alternative to gadolinium (Gad)-enhanced MRI in characterization vertebral marrow infiltrative lesions. A prospective evaluation fifty-six patients with suspected or untreated metastases undergoing spine at 1.5 T was carried out. Two groups sequences were assigned and compared for lesions: group [A] unenhanced-mp (including T1-weighted, T2-weighted, short time inversion recovery...
Abstract Breast cancer is the second most common diagnosed worldwide. Human epidermal growth factor receptor 2 (HER2)‐positive breast represents about 20% to 30% of all cancers. Trastuzumab used in treatment HER2‐positive cancer. MicroRNA‐21 (miR‐21) an oncomiR that acts by inhibiting many tumor‐suppressor genes. We analyzed relative expression levels serum miR‐21 20 metastatic patients before and after 3 months with trastuzumab. decreased a high significant difference trastuzumab therapy (...
The management of early breast cancer (BC) has witnessed an uprise in the use neoadjuvant therapy and a remarkable reshaping systemic postneoadjuvant treatment last few years, with evolution many controversial clinical situations that require consensus.
Hepatitis C Virus (HCV) is an asymptomatic chronic infection with serious clinical consequences. Timely and sensitive detection of HCV RNA critical for control, treatment response follow up. While current technologies, such as PCR or isothermal amplification-based strategies, are specific, they expensive, labor intensive, time consuming limiting their use in field small laboratories.
Background: The management of patients with triple-negative breast cancer (TNBC) is challenging several controversies and unmet needs. During the 12th Breast-Gynaecological & Immuno-oncology International Cancer Conference (BGICC) Egypt, 2020, a panel 35 experts from 13 countries voted on consensus guidelines for clinical TNBC. was subsequently updated based most recent data evolved lately. Methods: A conference approach adapted American Society Clinical Oncology (ASCO) utilized....
The aim of the current study is to evaluate different treatment modalities used in management high-risk metastatic gestational trophoblastic tumors (GTT) between June 1992 and December 2004 at Gynecologic Oncology Unit, Ain Shams University. Out 261 patients diagnosed treated for GTT, 70 (26.8%) were high risk based on National Institutes Health clinical classification. mean age was 29.39 +/- 9.38 years (16-55 years), with six (8.6%) being older than 39 years, duration follow-up 79.74 40.44...
<b><i>Background:</i></b> Liver reserve affects survival in hepatocellular carcinoma (HCC). Model for End-Stage Disease (MELD) score is used to predict overall (OS) and prioritize HCC patients on the transplantation waiting list, but more accurate models are needed. We hypothesized that integrating insulin-like growth factor 1 (IGF-1) levels into MELD (MELD-IGF-1) improves OS prediction as compared MELD. <b><i>Methods:</i></b> measured plasma...