A5086404791- Hepatitis C virus research
- DNA and Nucleic Acid Chemistry
- Extraction and Separation Processes
- Agricultural pest management studies
- Cloud Data Security Solutions
- Hepatitis B Virus Studies
- Big Data and Business Intelligence
- Cryptographic Implementations and Security
- Analytical Chemistry and Chromatography
- Plant Physiology and Cultivation Studies
- Horticultural and Viticultural Research
- Distributed Sensor Networks and Detection Algorithms
- Enzyme Structure and Function
- Edible Oils Quality and Analysis
- Blockchain Technology Applications and Security
- Biochemical and Molecular Research
- Cloud Computing and Resource Management
- RNA and protein synthesis mechanisms
- Artificial Intelligence in Law
- Network Security and Intrusion Detection
- Advanced Graph Neural Networks
- Mineral Processing and Grinding
- Advanced Database Systems and Queries
- DNA Repair Mechanisms
- Protein Structure and Dynamics
University of Bremen
2024-2025
Monash University
2024
Australian Regenerative Medicine Institute
2024
National Institute of Technology Rourkela
2011-2022
Becton Dickinson (Canada)
2020-2021
University of Amsterdam
2021
Institute of Biosciences and Bioresources
2021
University of the Cumberlands
2018-2019
Technical Database Services (United States)
2019
Medical College and Hospital, Kolkata
2019
The hepatitis C virus (HCV) nonstructural protein 3 (NS3) is both a protease, which cleaves viral and host proteins, helicase that separates nucleic acid strands, using ATP hydrolysis to fuel the reaction. Many antiviral drugs, compounds in clinical trials, target NS3 but few inhibitors function as antivirals have been reported. This study focuses on analysis of mechanism by ebselen (2-phenyl-1,2-benzisoselenazol-3-one), compound previously shown be HCV agent, inhibits helicase. Ebselen...
The flavivirus nonstructural protein 3 (NS3) is a protease and helicase, on the basis of its similarity to homologue encoded by hepatitis C virus (HCV), NS3 might be promising drug target. Few helicase inhibitors have been reported, in part, because few specific identified when nucleic acid unwinding assays used screen for inhibitors. To explore possibility that compounds inhibiting NS3-catalyzed ATP hydrolysis function as antivirals even if they do not inhibit RNA vitro, we designed robust...
Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits are often confounded by compound interference. Oligonucleotide binding examined here as an alternative. After comparing fluorescence polarization (FP), homogeneous time-resolved (HTRF®; Cisbio) AlphaScreen® (Perkin Elmer) assays, FP-based assay was chosen screen Sigma's Library of Pharmacologically Active Compounds (LOPAC) for compounds NS3-DNA complex formation....
The progression of lung cancer is associated with inactivation programmed cell death protein 1, abbreviated as PD-1 which regulates the suppression body's immune system by suppressing T-cell inflammatory activity and responsible for preventing growth.It interest to identify inhibitors PD-L1 dimeric structure through molecular docking virtual screening.The screened compound XGIQBUNWFCCMAS-UHFFFAOYSA-N (PubChem CID: 127263272) displays a high affinity target protein.ADMET analysis cytotoxicity...
This article gives an overview of the benefits AWS in modern cloud. Cloud computing is performing well today's World and boosting ability to use internet more than ever. gradually developed a method it most organizations. It very demanding all businesses tasked with improving quality service reducing costs as organization pays for only what they consume based on incoming outgoing traffic.
This paper studies Federated Learning (FL) in low Earth orbit (LEO) satellite constellations, where satellites are connected via intra-orbit inter-satellite links (ISLs) to their neighboring satellites. During the FL training process, each forward gradients from nearby satellites, which eventually transferred parameter server (PS). To enhance efficiency of apply in-network aggregation, referred as incremental aggregation. In this work, gradient sparsification methods [1] applied scenarios...
Many commercial Large Language Models (LLMs) are often closed-source, limiting developers to prompt tuning for aligning content generation with specific applications. While these models currently do not provide access token logits, we argue that if such were available, it would enable more powerful adaptation techniques beyond engineering. In this paper, propose a token-level probability reweighting framework that, given logits and small amount of task-specific data, can effectively steer...
Aurintricarboxylic acid (ATA) is a potent inhibitor of many enzymes needed for cell and virus replication, such as polymerases, helicases, nucleases, topoisomerases. This study examines how ATA interacts with the helicase encoded by hepatitis C (HCV) reveals that interferes both nucleic ATP binding to enzyme. We show directly binds HCV prevent enzyme from interacting acids modulate affinity ATP, fuel action. Amino substitutions in DNA cleft or its site alter ability disrupt helicase-DNA...
Originating from the abnormal growth of neuroblasts, pediatric neuroblastoma affects age group below 15 years. It is an aggressive heterogenous cancer with a high morbidity rate. Biological marker GD2 synthesised by gene acts as powerful predictor cells. gangliosides are sialic acid-containing glycosphingolipids. Differential expression during brain development governs function GD2. The present study explains interaction its established inhibitors and discovers compound having binding...
In this work, butyric acid (BA) was extracted using trioctyl amine (TOA). Various temperature-dependent (298.15–318.15 K) process parameters were estimated and analyzed. To reduce the harmful effects of TOA to avoid detrimental toxic diluents on microorganisms, green nontoxic diluents, sunflower soybean oils, tested. physical extraction, KDdil partition coefficient, P, decreased in order 1-decanol > oil oil, whereas dimerization constant, D, showed opposite trend. chemical extraction...
Coal is one of the most essential resources a country. It widely used for power generation and as raw material in industries. India ranks third coal production. However, country has to import order meet rising demand coal. In India, mining conducted using two methods: underground opencast methods. The method suitable extraction deeper seams, whereas shallow seams. due less production cost, mechanisation, wastage, dominates (93.26% total financial year 2016-17). Underground shows declining...
Hepatitis C (HCV) protein 3/4A (NS3/4A) is a bifunctional enzyme comprising two separate domains with protease and helicase activities, which are essential for viral propagation. Both stable have enzymatic activity separately, the relevance implications of having together as single remains to be explored. Altered in vitro activities isolated compared full-length NS3/4A suggest existence interdomain communication. The molecular mechanism extent this communication was investigated by probing...
This article gives the overview of different database encryption choices in SQL Server.Which one works best which situation.In today's world Data is more crucial than expensive hardware cost.No wants their personal data to be comprised.Same for business houses as well and they also do not want inappropriately handled go out business.To help protect public rights safety, recently this year, European Union had come up with strict rules regulation GDPR (General Protection Regulation).
Abstract RNA splicing, and variations in this process referred to as alternative are critical aspects of gene regulation eukaryotes. From environmental responses plants being a primary link between genetic variation disease humans, splicing differences confer extensive phenotypic changes across diverse organisms (1–3). Regulation occurs through differential selection splice sites reaction, which results the abundance isoforms and/or events. However, genomic determinants that influence...
The dimorphic fungus, Penicillium marneffei, produces and secretes a brick red pigment, during growth at temperatures below 30°C. It generally diffuses into commonly used media like Sabouraud dextrose agar malt extract agar. pigment was purified by reverse-phase liquid chromatography subjected to structural determination elemental spectral analysis using atomic absorption (AAS), ultra violet visible (UV-VIS), fluorescence, infra (IR), nuclear magnetic resonance (NMR) tandem mass spectrometry...