Ignacio Sajoux

ORCID: 0000-0002-9405-9809
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About
Contact & Profiles
Research Areas
  • Diet and metabolism studies
  • Adipose Tissue and Metabolism
  • Diet, Metabolism, and Disease
  • Bariatric Surgery and Outcomes
  • Pharmacology and Obesity Treatment
  • Muscle metabolism and nutrition
  • Dietary Effects on Health
  • Body Contouring and Surgery
  • Gut microbiota and health
  • Health and Lifestyle Studies
  • Adipokines, Inflammation, and Metabolic Diseases
  • Gastrointestinal motility and disorders
  • Liver Disease Diagnosis and Treatment
  • Dermatological and COVID-19 studies
  • Fatty Acid Research and Health
  • Regulation of Appetite and Obesity
  • Body Composition Measurement Techniques
  • Cardiovascular Health and Disease Prevention
  • Cardiovascular Function and Risk Factors
  • Eating Disorders and Behaviors
  • Epigenetics and DNA Methylation
  • Ovarian function and disorders
  • Breast Implant and Reconstruction
  • Cardiovascular Disease and Adiposity
  • Metabolism, Diabetes, and Cancer

PronoKal Group (Spain)
2016-2025

Instituto de Investigación Sanitaria de Santiago
2019-2024

Servicio Gallego de Salud
2019-2024

Complejo Hospitalario Universitario de Santiago
2019-2024

Fundación Pronokal
2020-2022

Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione
2019

Hospital de Sant Pau
2018

Yahoo (Spain)
2015

Abstract Brackground: The safety and tolerability of very low-calorie-ketogenic (VLCK) diets are a current concern in the treatment obese type 2 diabetes mellitus (T2DM) patients. Objective: Evaluating short-term VLCK diet (<50 g carbohydrate daily) an interventional weight loss program including lifestyle behavioral modification support (Diaprokal Method) subjects with T2DM. Methods: Eighty-nine men women, aged between 30 65 years, T2DM body mass index 35 kg m − participated this...

10.1038/nutd.2016.36 article EN cc-by Nutrition and Diabetes 2016-09-19

Abstract Context: Common concerns when using low-calorie diets as a treatment for obesity are the reduction in fat-free mass, mostly muscular that occurs together with fat mass (FM) loss, and determining best methodologies to evaluate body composition changes. Objective: This study aimed very-low-calorie ketogenic (VLCK) diet-induced changes of obese patients compare 3 different used those Design: Twenty followed VLCK diet 4 months. Body assessment was performed by dual-energy X-ray...

10.1210/jc.2016-2385 article EN The Journal of Clinical Endocrinology & Metabolism 2016-10-18

Psychological well-being and hunger food control are two relevant factors involved in the success of weight-loss therapy treating obesity. Thus, this study aims to evaluate alcohol cravings, physical sexual activity, sleep, life quality (QoL) obese patients following a very low-calorie ketogenic (VLCK) diet, as well role weight lost ketosis on these parameters. A battery psychological test was performed twenty (12 females, 47.2 ± 10.2 year BMI 35.5 4.4) through course 4-month VLCK diet four...

10.3390/nu10101348 article EN Nutrients 2018-09-21

The resting metabolic rate (RMR) decrease, observed after an obesity reduction therapy is a determinant of short-time weight regain. Thus, the objective this study was to evaluate changes in RMR, and associated hormonal alterations obese patients with very low-calorie ketogenic (VLCK)-diet induced severe body (BW) loss.From 20 who lost 20.2 kg BW 4-months VLCK-diet, blood samples composition analysis, determined by DXA MF-Bioimpedance, RMR indirect calorimetry, were obtained on four...

10.1186/s12986-018-0249-z article EN cc-by Nutrition & Metabolism 2018-02-17

BBackground: Currently the treatment of nonalcoholic fatty liver disease (NAFLD) is based on weight loss through lifestyle changes, such as exercise combined with calorie-restricted dieting. Objectives: To assess effects a commercially available program Very Low-Calorie Ketogenic Diet (VLCKD) Visceral Adipose Tissue (VAT) and fat content compared to standard diet (LC). As secondary aim we evaluated effect stiffness measurements. Methods: Open, randomized, controlled, prospective pilot study....

10.3389/fendo.2020.00607 article EN cc-by Frontiers in Endocrinology 2020-09-14

Scope Little is known about the changes that a very‐low‐calorie ketogenic diet (VLCKD) produces in gut microbiota or effect of synbiotics during diet. The aim this study to evaluate produced by VLCKD and synbiotic supplementation. Methods results A randomized, single‐blind, parallel‐design trial conducted 33 obese patients who follow weight‐loss program (PnK‐Method) include followed low‐calorie (LCD). Subjects are randomly allocated three groups: one supplemented with synbiotics, second...

10.1002/mnfr.201900167 article EN Molecular Nutrition & Food Research 2019-07-12

The preservation of muscle mass and function after weight loss therapy is currently a considerable challenge in the fight against obesity. Muscle secretes proteins called myokines that have relevant functions regulation metabolism health. This study was aimed to evaluate whether very low-calorie ketogenic (VLCK) diet may modulate myokine levels, addition changes body composition, compared standard, balanced (LC) or bariatric surgery patients with Body ketosis, insulin sensitivity were...

10.3390/nu11102368 article EN Nutrients 2019-10-04

The aim of this study isto assess the efficacy a very low-calorie ketogenic diet (VLCKD) method vs Mediterranean (LCD) in obese polycystic ovary syndrome (PCOS) women reproductive age.Randomized controlled open-label trial was performed study. treatment period 16 weeks; VLCKD for 8 weeks then LCD weeks, according to Pronokal® (experimental group; n = 15) (control 15). Ovulation monitoring carried out at baseline and after while clinical exam, bioelectrical impedance analysis (BIA),...

10.1530/ec-22-0536 article EN cc-by-nc-nd Endocrine Connections 2023-04-05

BackgroundThe molecular mechanisms underlying the potential health benefits of a ketogenic diet are unknown and could be mediated by epigenetic mechanisms.ObjectiveTo identify changes in obesity-related methylome that induced weight loss or dependent on ketosis subjects with obesity underwent very-low calorie (VLCKD).MethodsTwenty-one patients (n = 12 women, 47.9 ± 1.02 yr, 33.0 0.2 kg/m2) after 6 months VLCKD normal volunteers 50.3 6.2 yrs, 22.7 1.5 were studied. Data from Infinium...

10.1016/j.clnu.2021.05.010 article EN cc-by-nc-nd Clinical Nutrition 2021-05-21

Options for treatment of obesity include dietary approaches and bariatric surgery. Previous studies have shown that weight loss interventions an impact on gut microbiota. However, a pattern microbiota changes associated with independently the type intervention has not been described yet. This study includes 61 individuals who followed different strategies in three trials: 21 hypocaloric Mediterranean diet (MedDiet), 18 very-low-calorie ketogenic (VLCKD) 22 patients underwent sleeve...

10.3390/jpm11020109 article EN Journal of Personalized Medicine 2021-02-08

Weight loss after bariatric surgery decreases the earlier expansion of adventitial vasa vasorum (VV), a biomarker early atheromatous disease. However, no data are available regarding weight achieved by very low calorie ketogenic diets (VLCKD) on VV and lipid-based atherogenic indices. A randomized clinical trial was performed to examine changes in density 20 patients with moderate obesity who underwent 6-month diet (VLCKD, 600-800 kcal/day), 10 participants hypocaloric based Mediterranean...

10.3390/nu14010033 article EN Nutrients 2021-12-23
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