A5005138004- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Rangeland Management and Livestock Ecology
- Genetic and phenotypic traits in livestock
- Cell Adhesion Molecules Research
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Conservation, Biodiversity, and Resource Management
- Agricultural Systems and Practices
- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- 14-3-3 protein interactions
- Cancer, Hypoxia, and Metabolism
- Soil erosion and sediment transport
- Cancer-related molecular mechanisms research
- Medicinal Plant Pharmacodynamics Research
- RNA modifications and cancer
- Animal Diversity and Health Studies
Oregon Health & Science University
2023-2024
University of Utah
2018-2022
Huntsman Cancer Institute
2016-2022
Adigrat University
2017-2020
The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge developmental kinetics mechanisms lineage specification is lacking. We address this significant gap by generating a single-cell transcriptome atlas encompassing embryonic, postnatal, adult mouse development. From these data, we map the chronology transcriptionally epigenetically distinct cell states distinguish fetal stem (fMaSCs) from...
Ethiopia is endowed with diverse cattle genetic resources adapted to various local environmental conditions and acquired unique features. Describing of the characteristics, necessity urgency understand utilize these respond needs people nation benefit Ethiopian producers. Thus, this review aimed summaries resources, their features, main causes threat for survival recommend on improvement conservation strategies. Today, we find a variety genetically population from Bos taurus indicus species...
Abstract Background CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed antagonist, ALK4 L75A -Fc, showed it causes loss of the stem cell phenotype in normal mammary epithelia suggesting may similarly inhibit CRIPTO-dependent plasticity breast cancer cells. Methods focused on two triple negative lines (MDA-MB-231 MDA-MB-468) to measure effects -Fc behavior under nutrient deprivation endoplasmic reticulum stress. characterized...
Breast cancers are categorized into subtypes with distinctive therapeutic vulnerabilities and prognoses based on their expression of clinically targetable receptors gene patterns mimicking different cell types the normal gland. Here, we tested role Mcam in breast cancer state control tumorigenicity a luminal progenitor-like murine tumor line (Py230) that exhibits lineage subtype plasticity. knockdown Py230 cells show augmented Stat3 Pi3K/Akt activation associated switch away from...
Abstract To establish and maintain functional properly formed tissues, cells must integrate cues from their environment into fate decisions. External cues—from other the extracellular matrix for instance—must be met with appropriate responses to ensure cell decisions that control lineage plasticity favor proper development, maintenance, or regeneration of tissues while suppressing neoplastic transformation. MCAM (CD146; MUC18; S-endo-1; Gicerin) is an integral membrane glycoprotein whose...
Abstract The ability of cancer cells to adapt various extrinsic challenges such as nutrient deprivation, hypoxia and chemotherapy may underlie their tumorigenicity well disseminate distant organs. Therefore, identifying molecular mechanisms that govern cellular plasticity be critical the development anti-cancer therapies target situationally defined tumor stem in metastasis, resistance, dormancy recurrence. We considered GPI-anchored/secreted Cripto protein an excellent this regard, it...
Abstract Parallels among embryonic development, stem cells, and cancer have long been recognized. We identified, isolated, characterized cells that first become committed to a mammary fate during embryogenesis; we refer these as fetal (fMaSCs). Lineage tracing, in vitro sphere formation, vivo transplantation studies by our group many others all confirm the embryo are bipotent progenitors of gland. There is debate, however, on whether such persist into adult, or luminal basal lineages...
Abstract CD146 (Mcam; Muc18; s-endo; and gicerin) is an integral membrane glycoprotein originally identified in a human malignant melanoma, but mis-expressed wider variety of malignancies including breast cancer, where it has been implicated controlling tumor growth dissemination. The mechanisms by which conveys extracellular cues into cellular outputs not well understood, its high-level expression early development normal mouse mammary stem cells, as highly plastic adult pericytes (formerly...