A5065243682- Microwave-Assisted Synthesis and Applications
- Chemical Synthesis and Reactions
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Analysis
- Synthesis and Reactions of Organic Compounds
- Epigenetics and DNA Methylation
- Inorganic and Organometallic Chemistry
- Hepatitis Viruses Studies and Epidemiology
- Carbon Nanotubes in Composites
- Synthesis and biological activity
- Nanomaterials for catalytic reactions
- Click Chemistry and Applications
- Eicosanoids and Hypertension Pharmacology
- Nanotechnology research and applications
- Ionic liquids properties and applications
- Sulfur-Based Synthesis Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Synthesis of Organic Compounds
- Chemical synthesis and pharmacological studies
- Gout, Hyperuricemia, Uric Acid
- Toxoplasma gondii Research Studies
University of Turin
2008-2017
Max Planck Institute for Heart and Lung Research
2017
Goethe University Frankfurt
2017
Scripps Research Institute
2009
Friedrich Schiller University Jena
2008
The syntheses of almost all N-heterocycles have now been successfully performed under microwave irradiation and provided significant improvements in the reaction time efficiency. peculiar properties dielectric heating give it ability to strongly promote cyclocondensation, cycloaddition selective N-heterocycle functionalisation has, therefore, very much caught attention medicinal chemistry community. In this work, we present an overview recent literature technical advances research field with...
Pyroptosis is a caspase-1-dependent pro-inflammatory form of programmed cell death implicated in the pathogenesis autoinflammatory diseases as well disorders characterized by excessive and inflammation. Activation NLRP3 inflammasome key event pyroptotic cascade. In this study, we describe synthesis chemical tuning α,β-unsaturated electrophilic warheads toward development antipyroptotic compounds. Their pharmacological evaluation structure–activity relationships are also described. Compound 9...
Abstract NLRP3 inflammasome plays a key role in the intracellular activation of caspase‐1, processing pro‐inflammatory interleukin‐1β (IL‐1β), and pyroptotic cell death cascade. The overactivation is implicated pathogenesis autoinflammatory diseases, known as cryopyrin‐associated periodic syndromes (CAPS), progression several such atherosclerosis, type‐2 diabetes, gout, Alzheimer's disease. In this study, synthesis acrylamide derivatives their pharmaco‐toxicological evaluation potential...
ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTUltrasound-Promoted Copper-Catalyzed Azide−Alkyne CycloadditionGiancarlo Cravotto*†, Valery V. Fokin‡, Davide Garella†, Arianna Binello†, Luisa Boffa†, and Alessandro Barge†View Author Information Dipartimento di Scienza e Tecnologia del Farmaco, Università Torino, Via Giuria 9, 10125 Italy, Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037* To whom correspondence should be addressed....
The ultrasound-assisted cross-linking of chitosan with hexamethylene diisocyanate the simultaneous incorporation Pd(OAc)2 resulted in a catalyst which is suitable for solid-state Suzuki cross-coupling poorly reactive (hetero)aryl chlorides phenylboronic acid. Reactions were carried out solvent-free planetary ball mill allowing to be recycled several times.
Rationale: Human cardiac mesenchymal cells (CMSCs) are a therapeutically relevant primary cell population. Diabetes mellitus compromises CMSC function as consequence of metabolic alterations and incorporation stable epigenetic changes. Objective: To investigate the role α-ketoglutarate (αKG) in epimetabolic control DNA demethylation CMSCs. Methods Results: Quantitative global analysis, methylated hydroxymethylated sequencing, gene-specific GC methylation detection revealed an accumulation...
Abstract Heck couplings were carried out ligandless in air with very low catalyst loads under microwave or simultaneous microwave/ultrasound irradiation. Using ligand‐free palladium(II) acetate [Pd(OAc) 2 ] the range of 0.01–0.1 mol % palladium‐on‐carbon (Pd/C) 10 1.0–2.0 %, most aryl iodides and bromides gave high yields conventional heating (120 °C) 18 h. Microwave irradiation alone or, better still, combined high‐intensity ultrasound, strongly promotes reaction, generally decreasing...
Abstract A fast, solvent-free method is described for the synthesis of substituted quinoline derivatives via Friedländer cyclization, employing a reusable solid catalyst (silica-propylsulfonic acid). Although it worked best under microwave irradiation (with generally more than 90% isolated yields in 30 min), reaction was also feasible conventional heating fair to good about 5 h). Keywords: synthesismicrowavesquinolinesolid catalystsolvent-free ACKNOWLEDGMENTS Support this research by...
Organosulphur compounds can be easily and selectively oxidized to sulfones using a small excess of Oxone® (1.6 eq.) under solventless mechanical milling conditions. This green procedure has been efficiently applied series model the desulphurization medium/high sulphur content paraffins (up 3000 mg kg−1).
The use of ultrasound (US) and microwaves (MW) in the oxidation purification multi-walled carbon nanotubes (MWCNTs) was investigated. These techniques, particular US at a frequency 300 kHz, strongly accelerate process avoid heavy structural damage, observed 20–35 kHz classic range, even low power. Due to residual metal catalyst on head MWCNTs, MW heating is absorbed, causing rupture tip loss metal. All our chemico-physical treatment types were performed by suspending CNTs 3 ∶ 1 H2SO4/HNO3...
The Huisgen 1,3-dipolar cycloaddition of azides and acetylenes catalyzed by Cu(I) salts, leading to 1,2,3-triazoles, is one the most versatile "click reactions". We have developed a series optimized protocols new applications this reaction starting from several substrates, comparing heterogeneous vs homogeneous catalysis, conventional heating microwave irradiation or simultaneous microwave/ultrasound irradiation. Both non-conventional techniques strongly promoted (bromide → azide triazole),...
The inhibition of human DNA Methyl Transferases ( DNMT ) is a novel promising approach to address the epigenetic dysregulation gene expression in different diseases. Inspired by validated virtual screening hit NSC 137546, series N ‐benzoyl amino acid analogues was synthesized and obtained compounds were assessed for their ability inhibit ‐dependent methylation vitro . biological allowed definition set preliminary structure–activity relationships identification further development. Among...
This study proposes an alternative technique to prevent heat degradation induced by classic procedures of bioactive compound extraction, comparing classical maceration/decoction in hot water polyphenols from Mango (Mangifera indica L.) (MI) with ultrasound-assisted extraction (UAE) a solution β-cyclodextrin (β-CD) at room temperature and testing their biological activity on TNFα-induced endothelial dysfunction. Both extracts counteracted TNFα effects EAhy926 cells, down-modulating...
Abstract The oxidation of primary aromatic amines, p-methylaniline, p-ethylaniline and p-chloroaniline to the corresponding azo- azoxy-compounds has been observed in ultrasound and/or microwaves systems. individual irradiation its simultaneous with obviously elevate conversion as compared heating a plain water bath. However, formation formamidine resulted poor selectivity toward azo azoxy products presence dimethylformamide (DMF). ACKNOWLEDGMENT authors acknowledge support from Cesare Buffa...
Heck reactions and Suzuki-Miyaura cross-couplings with relatively poorly reactive 3,5-dichloro-2-pyrazinones were studied at the same temperature under conventional heating, dielectric heating (MW) simultaneous MW/US irradiation. This comparative study showed a synergic effect of combined MW US irradiation resulting in much higher reaction yield, time avoiding side partial degradation that is otherwise observed heating.
A novel, efficient, and rapid synthesis of the 6-aminoperhydro-1,4-diazepine scaffold is reported. It was promoted by microwave or sequential ultrasound/microwave irradiation under solvent-free conditions in solution. Protected ethylenediamine derivatives N-Boc-serinol dimesylate underwent cyclization to give 6-aminoperhydro-1,4-diazepine excellent yields with high selectivity, whereas same reaction failed gave negligible conventional heating. Cesium potassium ions catalyzed ring closure...
The Fisher esterification is an equilibrium reaction and generally requires the removal of water and/or use excess amounts reactants if satisfactory conversion rates are to be obtained. 1...