A5071849213- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Gout, Hyperuricemia, Uric Acid
- Ubiquitin and proteasome pathways
- Toxoplasma gondii Research Studies
- Eicosanoids and Hypertension Pharmacology
- French Urban and Social Studies
- Sphingolipid Metabolism and Signaling
- Climate Change and Geoengineering
- Sustainable Industrial Ecology
- Sustainability and Climate Change Governance
- Immunotherapy and Immune Responses
- Heme Oxygenase-1 and Carbon Monoxide
Centre National de la Recherche Scientifique
2016-2024
Centre International de Recherche en Infectiologie
2016-2024
École Normale Supérieure de Lyon
2016-2024
Université Claude Bernard Lyon 1
2016-2024
Inserm
2016-2024
Institut de Génomique Fonctionnelle de Lyon
2018
MRC University of Glasgow Centre for Virus Research
2015
Laboratoire Reproduction et Développement des Plantes
2014
Abstract NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling inflammasome. Upon coordinated priming activation stimuli, recruits NEK7 within hetero-oligomers that nucleate ASC caspase-1 filaments, but apical molecular mechanisms underlying inflammasome assembly remain elusive. Here we show recruitment to is controlled phosphorylation status S803 located interaction surface, in which phosphorylated upon later dephosphorylated activation. Phosphomimetic...
NLRP3-associated autoinflammatory disease is a heterogenous group of monogenic conditions caused by NLRP3 gain-of-function mutations. The poor functional characterization most variants hinders diagnosis despite efficient anti-IL-1 treatments. Additionally, while controlled priming and activation signals, gain-of-functions have only been investigated in response to priming. Here, we characterize 34 vitro, evaluating their activity upon induction, priming, and/or sensitivity four inhibitors....
Abstract NLRP3 inflammasome plays a key role in the intracellular activation of caspase‐1, processing pro‐inflammatory interleukin‐1β (IL‐1β), and pyroptotic cell death cascade. The overactivation is implicated pathogenesis autoinflammatory diseases, known as cryopyrin‐associated periodic syndromes (CAPS), progression several such atherosclerosis, type‐2 diabetes, gout, Alzheimer's disease. In this study, synthesis acrylamide derivatives their pharmaco‐toxicological evaluation potential...
Covalent linkage to members of the small ubiquitin-like (SUMO) family proteins is an important mechanism by which functions many cellular are regulated. Sumoylation has roles in control protein stability, activity and localization, involved regulation transcription, gene expression, chromatin structure, nuclear transport RNA metabolism. also linked, both positively negatively, with replication different viruses terms modification viral modulation sumoylated that influence efficiency...
Abstract NLRP3-associated autoinflammatory disease (NLRP3-AID or CAPS) is an heterogenous group of monogenic autoinflammations associated with NLRP3 gain-of-function mutations. The poor functional characterization most variants a barrier to diagnosis although patients can be efficiently treated anti-IL-1 approaches. In addition, while inflammasome controlled by coordinated priming and activation signals, gain-of-functions have been only investigated in response priming. Here, we functionally...