A5020584340- Biosensors and Analytical Detection
- Microfluidic and Bio-sensing Technologies
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Capillary Electrophoresis Applications
- RNA Interference and Gene Delivery
- Coccidia and coccidiosis research
- Nanoparticle-Based Drug Delivery
- Advanced Biosensing Techniques and Applications
- Parasitic Infections and Diagnostics
- RNA Research and Splicing
- Nuclear Structure and Function
- Ocular Infections and Treatments
- Amoebic Infections and Treatments
- Oral microbiology and periodontitis research
- Circadian rhythm and melatonin
- Stress Responses and Cortisol
- Bacteriophages and microbial interactions
- Cytomegalovirus and herpesvirus research
- Salivary Gland Disorders and Functions
- Neuroendocrine regulation and behavior
- Advanced Proteomics Techniques and Applications
- Enterobacteriaceae and Cronobacter Research
- Neuroblastoma Research and Treatments
- Graphene research and applications
- 3D Printing in Biomedical Research
Texas State University
2003-2016
Rice University
2010-2013
The University of Texas Health Science Center at Houston
2010
The University of Texas MD Anderson Cancer Center
2010
The University of Texas Health Science Center at San Antonio
2010
The University of Texas Medical Branch at Galveston
2009
The University of Texas at Austin
2003-2007
Texas A&M University
2002
Oral cancer is a deadly and disfiguring disease that could greatly benefit from new diagnostic approaches enabling early detection. In this pilot study, we describe nano-bio-chip (NBC) sensor technique for analysis of oral biomarkers in exfoliative cytology specimens, targeting both biochemical morphologic changes associated with tumorigenesis. Here, lesions 41 dental patients, along normal epithelium 11 healthy volunteers, were sampled using noninvasive brush biopsy technique. Specimens...
Oral cancer is the sixth most common worldwide and has been marked by high morbidity poor survival rates that have changed little over past few decades. Beyond prevention, early detection crucial determinant for successful treatment of cancer. Yet current methodologies diagnosis based upon pathological examination alone are insufficient detecting tumor progression molecular transformation. To address this clinical need, we developed a cell-based sensor to detect oral biomarkers, such as...
In this paper, we present a graphene field effect transistor (FET) fabricated on flexible Kapton substrate using 3-D inkjet printing for use as biosensor to detect infectious organisms. Inkjet process of film is described with sheet resistance low 110 Q/sq. To suppress background noises, the biosensors are based intensity changes ac signal function biological agents' concentration. Using foodborne pathogen, Norovirus, proof-of-concept disease target, value S12 (i.e., voltage gain from source...
Abstract Melatonin is an important hormone regulating circadian clocks in birds, but the specific cellular sites of action are not completely known. The present study was designed to determine whether astrocytes derived from chick brain contained functional melatonin receptors. Primary cell cultures diencephalon that express glial fibrillary acidic protein (GFAP), neuron‐specific enolase (NSE) immunoreactivity, were employed distribution and physiological role for three known receptor...
We report on a novel strategy for the detection of mRNA targets derived from Cryptosporidium parvum oocysts by use oligonucleotide-gold nanoparticles. Gold nanoparticles are functionalized with oligonucleotides which complementary to unique sequences present heat shock protein 70 (HSP70) DNA/RNA target. The results indicate that presence HPS70 increasing complexity causes formation nanoparticle networks can be visually monitored via simple colorimetric readout measured total internal...
Inflammation has been identified as the underlying cause of atherosclerosis, a condition associated with deposition lipids in lining arteries, which progressively leads to acute myocardial infraction (AMI) or heart attack. Serum concentrations markers inflammation, including C-reactive protein (CRP), and leukocyte count are powerful predictors for development coronary disease (1)(2)(3)(4)(5)(6)(7). In addition, AMI patients increased CRP counts at higher risk mortality recurrent...
This study describes the development and evaluation of an amplification-free molecular assay for detection Cryptosporidium parvum oocysts. The employed a pair oligonucleotide-functionalized gold nanoparticle (AuNP) probes that were complementary to adjacent sequences on C. 18s rRNA. Hybridization target RNA resulted in assembly AuNPs into target-linked networks, which detected both visibly spectroscopically, by redshift wavelength light scattered nanoparticles. limit was between 4 × 105 106...
A diagnostic cytology-on-a-chip technique rapidly detects pre-malignant and malignant cells with high sensitivity specificity.
Nuclear objects that have in common the property of being recognized by monoclonal antibodies specific for phosphoprotein epitopes and cytoplasmic intermediate filaments (in particular, SMI-31 RT-97) been reported glial neuronal cells, situ vitro. Since neurofilament are generally considered to be restricted cytoplasm, we were interested exploring identity structures labeled nucleus as well conditions under which they could found there. Using confocal microscopy western analysis techniques,...
<p class="ArticleTitle"><span lang="EN-US">Neuroblastoma is one of the most common and aggressive types pediatric cancers, making up about 7% all childhood cancers. Neuroblastoma arises from failure neural crest cell precursors to differentiate, inducing differentiation important treatment approaches for neuroblastoma. MicroRNAs regulate gene expression by performing post-transcriptional modification mainly translational suppression mRNA degradation. The dysregulation these...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death worldwide, particularly in regions where chronic Hepatitis B and C infections are common. Nanoparticle assemblies that incorporate high-affinity aptamers which specifically bind malignant hepatocellular cells could be useful for targeted drug delivery or enhancing contrast with existing ablation therapies. The <i>in vitro</i> interactions a tumor-specific aptamer, TLS11a, were characterized hepatoma cell line...