A5100360187- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Biomarkers in Disease Mechanisms
- Axon Guidance and Neuronal Signaling
- Neurobiology and Insect Physiology Research
- Tryptophan and brain disorders
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- RNA and protein synthesis mechanisms
- Kruppel-like factors research
- Apelin-related biomedical research
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Diabetes and associated disorders
- Gene expression and cancer classification
- MicroRNA in disease regulation
- Asthma and respiratory diseases
- Advanced biosensing and bioanalysis techniques
- Pharmacogenetics and Drug Metabolism
Sichuan University
2025
West China Hospital of Sichuan University
2025
Max Planck Research Unit for Neurogenetics
2019-2020
Shanghai Jiao Tong University
2010-2011
North Carolina State University
2010
Major depressive disorder (MDD) is a common psychiatric disease. Selective serotonin reuptake inhibitors (SSRIs) are an important class of drugs used in the treatment MDD. However, many patients do not respond adequately to SSRI therapy. We pharmacometabolomics-informed pharmacogenomic research strategy identify citalopram/escitalopram outcome biomarkers. Metabolomic assay plasma samples from 20 escitalopram remitters and nonremitters showed that glycine was negatively associated with (P =...
Circular tumor DNA (ctDNA) is a trace nucleic acid that functions as an essential marker. In this context, the present study proposes one-pot electrochemical analysis of ctDNA EGFR L858R in lung cancer leveraging Ag+-mediated nanosphere (I amplification) and cation exchange reaction (II amplification), Cu2+ acts signal molecule. Once target exists, it specifically destroys structure nanosphere@Ag+, large amounts Ag+ are released. After addition copper sulfide nanoparticles, can be replaced...
Abstract Background Olfactory receptor (OR) genes are the largest multi-gene family in mammalian genome, with 874 human and 1483 loci mouse (including pseudogenes). The expansion of OR gene repertoire has occurred through numerous duplication events followed by diversification, resulting a large number highly similar paralogous genes. These characteristics have made annotation complete complex task. Most been predicted silico typically annotated as intronless coding sequences. Results Here...
Objectives. Colony stimulating factor 2 receptor β (CSF2RB) encodes the protein which is common chain of high affinity for IL-3, IL-5 and CSF. It locates in linkage region 22q12.3 both bipolar disorder schizophrenia, expressed most cells. Methods. We carried out a large scale case–control study to test association between CSF2RB three major mental disorders Chinese Han population. Seven single nucleotide polymorphisms were genotyped 1140 affective patients (including 645 type I patients),...
Abstract Background: Olfactory receptor (OR) genes are the largest multi-gene family in mammalian genome, with 874 human and 1483 loci mouse (including pseudogenes). The expansion of OR gene repertoire has occurred through numerous duplication events followed by diversification, resulting a large number highly similar paralogous genes. These characteristics have made annotation complete complex task. Most been predicted silico typically annotated as intronless coding sequences. Results: Here...
<div>Abstract<p>Semaphorins are a large family of evolutionarily conserved morphogenetic molecules that associated with repelling axonal guidance. Intriguingly, recent researches indicate semaphorins involved in cancer progression. Semaphorin 4C (SEMA4C) has long been considered neuronal migration gene, but we detected it is also highly expressed many malignant human cancers. During an investigation subcutaneous tumor models, found SEMA4C expression promoted growth and We...
<p>S1. Apoptosis detected by TUNEL in MDA-MB-231 cells expressing shSEMA4C or EV. S2. Sema4C cDNA re-expressed these siSEMA4C could recover cell growth and ANG CSF secretion. S3. Expression of senescence-associated pathway proteins were examined using western blot post-transfection at the indicated time. S4. SEMA4C regulates angiogenesis. S5. The vascular integrity was EV tumours tumours. S6. Sections from tumors immunostained with anti-cd45 (white arrowhead) F4/80(black arrow)...
<p>S1. Apoptosis detected by TUNEL in MDA-MB-231 cells expressing shSEMA4C or EV. S2. Sema4C cDNA re-expressed these siSEMA4C could recover cell growth and ANG CSF secretion. S3. Expression of senescence-associated pathway proteins were examined using western blot post-transfection at the indicated time. S4. SEMA4C regulates angiogenesis. S5. The vascular integrity was EV tumours tumours. S6. Sections from tumors immunostained with anti-cd45 (white arrowhead) F4/80(black arrow)...
<div>Abstract<p>Semaphorins are a large family of evolutionarily conserved morphogenetic molecules that associated with repelling axonal guidance. Intriguingly, recent researches indicate semaphorins involved in cancer progression. Semaphorin 4C (SEMA4C) has long been considered neuronal migration gene, but we detected it is also highly expressed many malignant human cancers. During an investigation subcutaneous tumor models, found SEMA4C expression promoted growth and We...
ABSTRACT Olfactory receptor (OR) genes are the largest multi-gene family in mammalian genome, with over 850 human and nearly 1500 mouse. The expansion of OR gene repertoire has occurred through numerous duplication events followed by diversification, resulting a large number highly similar paralogous genes. These characteristics have made annotation complete complex task. Most been predicted silico typically annotated as intronless coding sequences. Here we developed an expert curation...
Olfactory receptor (OR) genes are the largest multi-gene family in mammalian genome, with 874 human and 1483 loci mouse (including pseudogenes). The expansion of OR gene repertoire has occurred through numerous duplication events followed by diversification, resulting a large number highly similar paralogous genes. These characteristics have made annotation complete complex task. Most been predicted silico typically annotated as intronless coding sequences. Here we developed an expert...
Abstract Background: Olfactory receptor (OR) genes are the largest multi-gene family in mammalian genome, with 874 human and 1483 loci mouse (including pseudogenes). The expansion of OR gene repertoire has occurred through numerous duplication events followed by diversification, resulting a large number highly similar paralogous genes. These characteristics have made annotation complete complex task. Most been predicted silico typically annotated as intronless coding sequences. Results: Here...