A5100621045- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Helminth infection and control
- Cancer-related molecular mechanisms research
- Parasite Biology and Host Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Cancer-related gene regulation
- Genetics and Neurodevelopmental Disorders
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- Heavy Metal Exposure and Toxicity
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Metabolism, Diabetes, and Cancer
- Chemical Synthesis and Analysis
- 14-3-3 protein interactions
- Trace Elements in Health
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Ginseng Biological Effects and Applications
East China University of Science and Technology
2020-2025
Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences
2020-2024
Sun Yat-sen University
2020-2024
Sun Yat-sen University Cancer Center
2020-2024
Zhengzhou University
2024
Northeast Agricultural University
2015-2024
Soochow University
2020-2024
Monash University Malaysia
2024
Hanzhong People's Hospital
2024
Ministry of Agriculture and Rural Affairs
2024
Thrombolysis with tissue plasminogen activator (tPA) provides the most common therapy for ischemic stroke onset within past 4.5 h. However, enhanced neutrophil infiltration and secondary blood-brain barrier injury caused by tPA administration have limited its therapeutic application, treatment is often accompanied hemorrhagic transformation. To overcome limitations of thrombolysis tPA, maximize efficacy, improve safety, herein, we report a cryo-shocked platelet-based cell-hitchhiking drug...
Abstract Background The activation of NOD-like receptor protein 3 (NLRP3) inflammasome-dependent pyroptosis has been shown to play a vital role in the pathology manganese (Mn)-induced neurotoxicity. Sodium para-aminosalicylic acid (PAS-Na) positive effect on treatment manganism. However, mechanism is still unclear. We hypothesized that PAS-Na might act through NLRP3. Methods microglial cell line BV2 and male Sprague-Dawley rats were used investigate impacts Mn-induced NLRP3 pyroptosis....
Abstract Inorganic nanomedicine has attracted increasing attentions in biomedical sciences due to their excellent biocompatibility and tunable, versatile functionality. However, the relatively poor accumulation retention of these nanomedicines targeted tissues have often hindered clinical translation. Herein, highly efficient, delivery, situ aggregation ferrocene (Fc)‐capped Au nanoparticles (NPs) are reported cucurbit[7]uril (CB[7])‐capped Fe 3 O 4 NPs (as an artificial target) that...
Aberrant accumulation of succinate has been detected in many cancers. However, the cellular function and regulation cancer progression is not completely understood. Using stable isotope-resolved metabolomics analysis, we showed that epithelial mesenchymal transition (EMT) was associated with profound changes metabolites, including elevation cytoplasmic levels. The treatment cell-permeable induced phenotypes mammary cells enhanced cell stemness. Chromatin immunoprecipitation sequence analysis...
A major problem faced by the agricultural industry is resistance of Haemonchus contortus to anthelmintic drugs. For a better understanding response H. IVM and for screening drug-resistance-related genes, we used RNA sequencing isobaric tags relative absolute quantification (iTRAQ) technology detect transcriptomic proteomic changes in after ivermectin treatment. An integrated analysis two omics showed that differentially expressed genes proteins were significantly enriched pathways amino acid...
Abstract Background Non‐small cell lung cancer (NSCLC) is a type of that occurs in the cells respiratory tract, and its development influenced by regulation circular RNAs (circRNAs). However, role circRNA carboxypeptidase A4 (circCPA4) progression NSCLC underlying mechanism remain relatively clear. Methods The study utilized both real‐time quantitative polymerase chain reaction (RT‐qPCR) western blot techniques to evaluate levels circCPA4, microRNA‐145‐5p (miR‐145‐5p), alanine, serine, or...
Protein methylation has attracted increasing attention due to its significant regulatory roles in various biological processes. However, the diversity of forms, subtle differences between methylated and nonmodified sites, their ultralow abundances pose substantial challenges for capturing isolating peptides from samples. Herein, we develop a chromatographic method that utilizes 4-sulfonylcalix[4]arene (SC4A) as mobile phase additive Click-Maltose stationary separate methylated/nonmethylated...
Macrophages are paramount to the initiation and procession of atherosclerosis, thus targeting macrophages in progress atherosclerosis is indispensable. Therefore, we perform vitro experiments investigate effects FGF-21 on atherosclerosis. First, use phorbol-12-myristate-13-acetate (PMA), a phorbol ester, induce THP-1 cells into as model. After that Ox-LDL foam simultaneously administrate with or not determine whether has formation related inflammatory response. Wound healing results show can...
Alkaloids are the most basic organic compounds involved in crucial physiological activities and widely found plants, animals microorganisms. Due to anti-inflammatory, anti-tumor, bacteriostatic, analgesic effects of alkaloids, previous research primarily focused on their medical utilization. In recent years, regarding alkaloids botanical pesticides has gradually intensified due low toxicity, easy degradation, environmental friendliness, compared with traditional chemical pesticides, while...
Abstract Glucose is an important energy source for living cells. Particularly, most tumor cells use glycolysis to harness their fast growth, invasion and metastasis even under aerobic conditions. Thus, reduction of the glucose level in cancer can lead suppression growth. Here, macrophage membrane dressed yeast, Trojan M‐yeast, developed, via coating surface yeast with membrane, targeted accumulation by starvation. Due inflammatory homing effects M‐yeast efficiently target colonize site,...
Objectives. The FoxP2 gene, located on 7q31, encodes a transcription factor. It was first discovered through investigations of large multigenerational family (the KE family) with rare severe speech and language disorder (Fisher et al., Nat. Genet. 1998;18:168; Lai Nature 2001;413:519). Subsequent studies gave powerful convincing functional evidence to the connection between (; Groszer Curr Biol 2008;18:354; Vernes New Engl J Med 359(22):2337). Language is commonly considered as core symptom...
Transforming growth factor-β (TGF-β) is known to promote breast cancer cell migration, invasion, and dissemination; however, the underlying molecular mechanisms are not yet well characterized. Here, we report that TGF-β induces pleckstrin-2 (PLEK2) expression by Smad3 signal transducer activator of transcription 3 (STAT3) activating PLEK2 promoter activity. Higher associated with poor prognosis in patients. Overexpression knockout experiments MDA-MB-231 MCF-7 cells revealed promotes...
A cell-based drug delivery system has emerged as a promising platform. Due to their innate inflammatory tropism, natural and engineered macrophages have exhibited targeted accumulation in tissues, which allowed of medicine for the treatment variety diseases. Nevertheless, live may take up metabolize it during preparation, storage, vivo delivery, sometimes causing unsatisfactory therapeutic efficacy. In addition, macrophage-based systems are usually freshly prepared injected, due poor...
Despite docetaxel combined with cisplatin and 5-fluorouracil (TPF) being the established treatment for advanced nasopharyngeal carcinoma (NPC), there are patients who do not respond positively to this form of therapy. However, mechanisms underlying lack benefit remain unclear. DCAF7 is identified as a chemoresistance gene attenuating response TPF therapy in NPC patients. promotes resistance metastasis cells vitro vivo. Mechanistically, serves scaffold protein that facilitates interaction...
Context: Recent genome-wide association studies have revealed that common variations and rare copy-number contribute to the risk of mental disorders.Rare recurrent microdeletions at 1q21.1 were reported be associated with schizophrenia, BCL9 gene was also a functional candidate for disorders.Objectives: To investigate validate whether exist in variation region, and, if so, determine these confer schizophrenia or other disorders.Design: A 3-stage case-control study.Setting:
Epigenetic regulation plays an important role in the development and progression of nasopharyngeal carcinoma (NPC), but epigenetic mechanisms underlying NPC metastasis remain poorly understood. Here, we demonstrate that hypermethylation UCHL1 promoter leads to its downregulation NPC. Restoration inhibited migration invasion cells vitro vivo, knockdown promoted cell vivo. Importantly, found interacts with CTTN, may function as a ligase promoting CTTN degradation by increasing K48-linked...
Abstract Background Epigenetic regulation plays an important role in the development and progression of nasopharyngeal carcinoma (NPC). However, epigenetic mechanisms underlying NPC metastasis remains poorly understood. We aimed to find functional genes which regulate identify therapeutic targets for treatment. Methods Bisulfite pyrosequencing was used analyze zinc finger protein 582 ( ZNF582 ) methylation tissues cell lines. Quantitative reverse transcription‐polymerase chain reaction...