A5091265171- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Cancer-related cognitive impairment studies
- SARS-CoV-2 and COVID-19 Research
- Immune cells in cancer
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Immune Cell Function and Interaction
Weizmann Institute of Science
2020-2025
Abstract Predicting the outcome of immunotherapy treatment in melanoma patients is challenging. Alterations genes involved antigen presentation and interferon gamma (IFNγ) pathway play an important role immune response to tumors. We describe here that overexpression PSMB8 PSMB9 , two major components immunoproteasome, predictive better survival improved immune-checkpoint inhibitors patients. study mechanism underlying this connection by analyzing antigenic peptide repertoire cells...
The human leukocyte antigen (HLA)-bound viral antigens serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve acquiring mutations, it is essential to identify a range of presented antigens. Using HLA peptidomics, we are able severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-derived peptides highly prevalent class I (HLA-I) molecules using infected cells well overexpression SARS-CoV-2 genes. We find 26 HLA-I and 36 II (HLA-II) peptides....
Cancer-associated fibroblasts (CAFs) are abundant components of the breast tumor microenvironment and major contributors to immune-modulation. CAFs regulate activity many immune cells including T-cells, macrophages dendritic cells, however little is known about their interaction with natural killer (NK) which constitute an important arm anti-tumor immunity. Using mouse models cancer ex-vivo co-cultures, we find that inhibit NK cell cytotoxicity towards cells. We unravel mechanism by...
Abstract Cancer associated fibroblasts (CAFs) are among the most abundant components of breast tumor microenvironment (TME) and major contributors to immune modulation. CAFs well-known regulate activity diverse types cells including T cells, macrophages dendritic however little is known about their interaction with Natural killer (NK) which constitute an important arm anti-tumor immunity. Here we find, using mouse models cancer ex-vivo co-cultures, that inhibit NK cell cytotoxicity towards...