A5087245701- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Adrenal Hormones and Disorders
- CAR-T cell therapy research
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Celiac Disease Research and Management
- Circadian rhythm and melatonin
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- Cancer-related cognitive impairment studies
- Diabetes and associated disorders
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Heat shock proteins research
Weizmann Institute of Science
2016-2025
Cancer-associated fibroblasts (CAFs) are abundant components of the breast tumor microenvironment and major contributors to immune-modulation. CAFs regulate activity many immune cells including T-cells, macrophages dendritic cells, however little is known about their interaction with natural killer (NK) which constitute an important arm anti-tumor immunity. Using mouse models cancer ex-vivo co-cultures, we find that inhibit NK cell cytotoxicity towards cells. We unravel mechanism by...
The autoimmune regulator (AIRE) is essential for the establishment of central tolerance and prevention autoimmunity. Interestingly, different AIRE mutations cause autoimmunity in either recessive or dominant-negative manners. Using engineered mouse models, we establish that some monoallelic mutants, including C311Y C446G, breakdown tolerance. By using RNAseq, ATACseq, ChIPseq, protein analyses, dissect underlying mechanisms their dominancy. Specifically, show result a lack expression, while...
Abstract Cancer associated fibroblasts (CAFs) are among the most abundant components of breast tumor microenvironment (TME) and major contributors to immune modulation. CAFs well-known regulate activity diverse types cells including T cells, macrophages dendritic however little is known about their interaction with Natural killer (NK) which constitute an important arm anti-tumor immunity. Here we find, using mouse models cancer ex-vivo co-cultures, that inhibit NK cell cytotoxicity towards...
Abstract Thymic epithelial cells (TEC) play an indispensable role in the development and selection of immunocompetent, yet self-tolerant T cells. To provide further insights into TEC functional developmental diversity, we utilized multiome analysis, which revealed a detailed atlas compartment based on their transcriptional states chromatin landscapes. The analysis also highlighted numerous unconventional subsets, shared striking similarities with functionally well-defined parenchymal...
Abstract Poor tumor vascularization is an obstacle to immunotherapy by CTLs. It impairs infiltration but also introduces hypoxia, known interfere with T cell migration. yet unknown how suboptimal affects CTL migration and function within tumors. To study this question, we combined immunohistochemistry of human melanoma samples two-photon imaging in live mice. Orthotopically implanted B16-OVA tumors were studied after adoptive transfer in-vitro matured antigen-specific OT-I In patients, CD8...