Simin Zafardoust

ORCID: 0000-0002-9536-395X
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About
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Research Areas
  • Reproductive Biology and Fertility
  • Ovarian function and disorders
  • Reproductive System and Pregnancy
  • Assisted Reproductive Technology and Twin Pregnancy
  • Endometriosis Research and Treatment
  • Preterm Birth and Chorioamnionitis
  • Uterine Myomas and Treatments
  • Reproductive Physiology in Livestock
  • Organ and Tissue Transplantation Research
  • Maternal and Perinatal Health Interventions
  • Tissue Engineering and Regenerative Medicine
  • Menstrual Health and Disorders
  • Reproductive Health and Contraception
  • Gynecological conditions and treatments
  • Reproductive Health and Technologies
  • Sexual function and dysfunction studies
  • Thermoregulation and physiological responses
  • Mesenchymal stem cell research

Academic Center for Education, Culture and Research
2015-2025

Biotechnology Research Center
2015-2024

Omid Fertility Clinic
2022

Objective: Repeated implantation failure (RIF) is a major challenge in reproductive medicine.On the other hand, there has not yet been established confirmed outcome regarding usage of platelet-rich plasma (PRP) women undergoing intracytoplasmic injection (ICSI) or in-vitro fertilization (IVF); hence, objective this study was to evaluate effect intrauterine infusion PRP on pregnancy outcomes ICSI.Methods: In prospective double-blind clinical trial, 100 with at least two previous unexplained...

10.5935/1518-0557.20210046 article EN JBRA 2021-11-24

Poor ovarian response (POR) significantly reduces the success rates of fertility treatments. This study investigates long-term efficacy and potential complications associated with autologous menstrual blood-derived mesenchymal stromal cells (MenSCs) therapy in improving outcomes for women POR. To evaluate MenSC longitudinal, single-center retrospective observational included 105 POR patients who received injections from August 2018 to September 2021. Participants were monitored at least 3...

10.1186/s13287-025-04278-6 article EN cc-by-nc-nd Stem Cell Research & Therapy 2025-04-12

Silymarin as an herbal drug has potent antioxidant effects that could make it a good choice for endometriosis therapy. The aim of the current study was to determine silymarin on induced endometrial lesion in rat model endometriosis.A total 32 mature, female Sprague-Dawley rats were allocated into 4 experimental groups. duration about 6 months. Endometriosis implants surgically prepared and autografted rats. Three weeks after induction, animals randomly four groups: Group 1 received...

10.1016/j.tjog.2018.10.011 article EN cc-by-nc-nd Taiwanese Journal of Obstetrics and Gynecology 2018-12-01

Background: The effect of anticoagulant medication in unexplained early recurrent pregnancy loss (RPL) patients is controversial. This clinical trial evaluated the low-molecular-weight heparin (LMWH) on outcomes these patients. Materials and Methods: study was performed as a single-blind randomized between 2016 2018. Samples were selected from who referred to Avicenna RPL clinic with history at least two previously happened miscarriages. eligibility defined strictly select homogenously. One...

10.4103/jrms.jrms_81_21 article EN cc-by-nc-sa Journal of Research in Medical Sciences 2022-01-01

Abstract Background Assisted reproduction faces a significant obstacle in the form of poor ovarian response (POR) to controlled stimulation. To address this challenge, mesenchymal stem cell therapy has been proposed as potential treatment for female infertility and/or restoration function POR women. Our previous research demonstrated that menstrual blood-derived-mesenchymal stromal cells (MenSCs) injected into ovaries women with can increase pregnancy rates. The objective study was examine...

10.1186/s13287-023-03568-1 article EN cc-by Stem Cell Research & Therapy 2023-11-15

Abstract Background In the last decade, luteal-phase ovarian stimulation (LPOS) has been suggested as an alternative controlled (COS) protocol for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles mainly women with a history of poor response (POR). The present randomized trial study aimed to compare outcomes follicular phase (FPOS) and LPOS protocols POR cases undergoing ICSI cycles. Methods Seventy-eight patients who met Bologna criteria underwent cycle were...

10.1186/s40834-024-00265-z article EN cc-by Contraception and Reproductive Medicine 2024-02-18

Premature ovarian insufficiency (POI) is a condition with impaired function that occurred in women before the age of 40. Considering POI are reproductive and their fertility sexual life afflicted by this disorder directly, present study aimed to investigate perception experience health (SRH).

10.1186/s12905-021-01197-5 article EN cc-by BMC Women s Health 2021-02-08

Abstract Study question To study the pH and uterine fluid composition in human uterus three days after a positive LH test or ovum pick-up. Summary answer The pick-up was 6.8. Concentrations of 37 components were determined fluid. What is known already In assisted reproductive technologies (ART), vitro culture preimplantation embryos to play crucial role success Vitro Fertilization (IVF) treatments. It affects live birth rates child outcomes such as weight. Numerous commercial embryo media...

10.1093/humrep/deae108.611 article EN Human Reproduction 2024-07-01

Background: Poor Ovarian Response (POR) to ovarian stimulation is a challenging factor in Assisted Reproduction Technology (ART). This study aimed compare the efficacy of conventional antagonist with high doses gonadotropin protocol double females POR. Methods: randomized clinical trial was conducted on 60 women aged >35 PORS at Avicenna Infertility Center, Tehran, Iran. The participants were randomly divided into 2 groups (n=30 /each). In group 1, from second day menstrual cycle, started...

10.18502/jimc.v7i4.16641 article EN Journal of Iranian Medical Council 2024-10-12

Study question: What are the temperature, pH and uterine fluid composition in human uterus three days following a positive LH test or ovum pick-up? Summary answer: The mean temperature was 36.94 ± 0.26°C, 6.76 0.22, concentrations of 37 components aspirated were successfully determined. is known already: Embryo culture conditions laboratory impact key outcomes IVF/ICSI treatments, such as quality embryos live birth rate after treatment, child outcomes, weight. Currently used conditions,...

10.1101/2024.11.18.623470 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-11-19

Premature ovarian insufficiency (POI) occurs in women before the age of 40. Although outcomes POI include its adverse effects on general health, sexual-reproductive and finally reduced quality life. One first consequences is a threat to female identity patients. The purpose present study was investigate perception experience with about identity.In this qualitative study, interviews were conducted 15 having POI. Data included participants' recorded voices that analyzed using conventional...

10.18502/jri.v24i1.11909 article EN Journal of Reproduction & Infertility 2023-02-08

Abstract Background The major obstacle associated with assisted reproduction is poor ovarian response (POR) to controlled stimulation. Consequently, mesenchymal stem cell therapy has been proposed as a potential treatment for female infertility and/or restoration of function in POR women. initial phase the study showed an increase pregnancy rate women who received menstrual blood-derived-mesenchymal stromal cells (MenSCs) into their ovaries. objective was evaluate whether this could improve...

10.21203/rs.3.rs-2604303/v1 preprint EN cc-by Research Square (Research Square) 2023-05-03
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